Parallel clinical and behavioural studies of adjuvant-induced arthritis in the rat: Possible relationship with ‘chronic pain’

Calvino, Bernard; Crepon-Bernard, Marie-Odile; Bars, D. Le

doi:10.1016/0166-4328(87)90032-5

Cited by 143 publications

(75 citation statements)

References 59 publications

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“…The one behavioural parameter that did show a signi cant, though variable change following treatment, was an increase in the frequency and duration of licking of the ventral abdomen. Similar attention to an affected area has previously been reported to imply the presence of pain and to re ect its severity (Calvino et al 1987, Hong & Abbott 1994, Abbott et al 1995. In the present study, however, this activity only increased following saline treatment, and occurred neither before nor after meloxicam or carprofen administration.…”

Section: Discussionsupporting

confidence: 83%

Behavioural assessment of the effects of tumour growth in rats and the influence of the analgesics carprofen and meloxicam

2004

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SummaryVery little is known concerning the occurrence of pain in cancer research models. We wished to establish whether a behaviour-based approach, originally developed to assess postoperative pain, could be used to determine positive effects of the analgesics carprofen and meloxicam in rats that might be experiencing pain during tumour development in an orthotopic model of bladder cancer. An invasive but non-metastatic rat bladder cancer cell line was surgically implanted into the bladder wall of 57 inbred Fisher344 rats. The rats underwent daily clinical assessments. When clinical signs consistent with chronic pain were apparent, behavioural data were collected from 44 animals during 2 3 10 min periods, immediately before and one hour after a subcutaneous injection of either physiological saline (0.9%; 0.2 ml/100 g), carprofen (5 mg/kg) or meloxicam (2 mg/kg). Treatmentassociated behaviour changes were then compared between groups. The lack of active behaviour, both before and after each treatment, was consistent with established clinical signs of pain. The rats were so inactive following the treatment that the behavioural technique we had previously developed was of comparatively little use in determining either pain severity or analgesic ef cacy. One very prominent effect, however, was an increase in ventral abdominal licking in the control (saline) group. As this was absent in rats given meloxicam or carprofen, and has previously been considered to indicate pain emanating from damaged tissue, it was concluded that the analgesic-treated rats gained at least some bene t from the drug treatments, but it was not possible to gauge the extent of this. Handling for examination or treatment may have intensi ed pain in rats in the control group, and so this should be avoided whenever possible. It is likely that post-surgical pain differs markedly from cancer pain, so a different set of behavioural markers may be needed to assess it effectively. More intensive behaviour monitoring may help to develop a suitable technique for detecting the onset of, and assess the severity of pain that may occur during tumour development.

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Section: Discussionsupporting

confidence: 83%

Behavioural assessment of the effects of tumour growth in rats and the influence of the analgesics carprofen and meloxicam

2004

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“…The adjuvant produces arthritis predominantly in the joints of hind limbs, promoting significant reduction of motor activity and an increase in itching and scratching behaviors (Calvino et al, 1987). In addition, increased sensitivity of the affected paw to pressure or flexion and extension of the inflamed joints and weight loss were observed.…”

Section: Resultsmentioning

confidence: 99%

Effect ofIndigofera aspalathoideson complete Freund’s adjuvant-induced arthritis in rats

Balasubramanian¹,

Kavimani²,

Ravichandiran

et al. 2009

Pharmaceutical Biology

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“…This model of chronic inflammatory pain has been largely described by several groups [18][19][20]. It leads to a strong peripheral inflammation and development of an autoimmune disease linked to the destruction of the cartilages of both hindpaws, forepaws and hips [20,21].…”

Section: Animal Modelmentioning

confidence: 99%

Role of NGF in Neuronal Plasticity in the Lateral Reticular Nucleus in Chronic Inflammatory Pain

Marchand¹,

Thibault²,

Grist³

et al. 2009

TOPAINJ

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Abstract:In pathological states, repetitive inputs from the ascending pathways involved in the genesis and integration of nociception, leads to molecular, anatomical and electrophysiological adaptive changes of these pathways, contributing to the development of pain chronicity. In the past, neurotrophic factors have been implicated in neuronal plasticity in adult central nervous system. We have previously described plastic changes associated with the up-regulation of NGF's high affinity receptor, TrkA, in the spinoreticular pathway in a chronic inflammatory pain model of arthritis induced by complete Freund's adjuvant. The present study investigated the role of central NGF in the maintenance of inflammatory pain. Analysis of TrkA and NGF expression revealed that they are expressed in the medial thalamus and several reticular nuclei of the brain stem such as the lateral reticular nucleus (LRt) and not in pathways classically described to be involved in the sensory-discriminative aspect of pain such as the lateral thalamus. In addition NGF was over-expressed in the LRt, lateral thalamus and cortex of polyarthritic rats. Using micro-injection of an adenoviral vector synthesizing NGF (or green fluorescent protein) in the LRt of normal animals, we showed that increased NGF levels in the LRt leads to the development of mechanical hypersensitivity and increased nocifensive behavior following an inflammatory stimulus. These results suggest that, NGF acts centrally as a possible molecular inducer of synaptic plasticity in the LRt in conditions of chronic inflammatory pain.

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Parallel clinical and behavioural studies of adjuvant-induced arthritis in the rat: Possible relationship with ‘chronic pain’

Cited by 143 publications

References 59 publications

Behavioural assessment of the effects of tumour growth in rats and the influence of the analgesics carprofen and meloxicam

Behavioural assessment of the effects of tumour growth in rats and the influence of the analgesics carprofen and meloxicam

Effect ofIndigofera aspalathoideson complete Freund’s adjuvant-induced arthritis in rats

Role of NGF in Neuronal Plasticity in the Lateral Reticular Nucleus in Chronic Inflammatory Pain

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