Parallel induction of the formation of dopamine and its metabolites with induction of tyrosine hydroxylase expression in foetal rat and human cerebral cortical cells by brain-derived neurotrophic factor and glial-cell derived neurotrophic factor

Theofilopoulos, Spyridon; Goggi, Julian; Riaz, S.; Jauniaux, Eric; Stern, Gerald; Bradford, H. F.

doi:10.1016/s0165-3806(01)00125-0

Cited by 38 publications

(16 citation statements)

References 62 publications

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“…Dopaminergic neurons in rat ventral midbrain were discovered to express BDNF-mRNA (Seroogy et al, 1994) and neurotrophin receptor TrkB and TrkC-mRNA (Numan and Seroogy, 1999). Several authors were able to detect BDNF in combination with dopamine to induce the dopaminergic phenotype in fetal rat and human cerebral cortex cultures (Hyman et al, 1994;Zhou et al, 1994Zhou et al, , 1996Zhou et al, , 1998Theofilopoulos et al, 2001;Riaz et al, 2002Riaz et al, , 2004. Stimulation with dopamine results in increased BDNF-mRNA and -protein in neuronal cultures (Küppers and Beyer, 2001).…”

Section: Discussionmentioning

confidence: 99%

Interaction between BDNF Val66Met and Dopamine Transporter Gene Variation Influences Anxiety-Related Traits

Hünnerkopf

Strobel²,

Gutknecht

et al. 2007

Neuropsychopharmacol

117

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The involvement in neural plasticity and the mediation of effects of repeated stress exposure and long-term antidepressant treatment on hippocampal neurogenesis supports a critical role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of affective and other stress-related disorders. A previously reported valine to methionine substitution at amino-acid position 66 (BDNF Val66Met) seems to account for memory disturbance and hippocampal dysfunction. In the present study, we evaluated the impact of the BDNF Val66Met polymorphism on individual differences in personality traits in a sample of healthy volunteers in relation to other common gene variants thought to be involved in the pathophysiology of affective disorders, such as the serotonin transporter promoter polymorphism (5-HTTLPR) and a variable number of tandem repeat polymorphism of the dopamine transporter gene (DAT VNTR). Personality traits were assessed using the NEO personality inventory (NEO-PI-R) and Tridimensional Personality Questionnaire (TPQ). There was a significant DAT VNTR-dependent association between NEO-PI-R Neuroticism and the BDNF Val66Met polymorphism. Among individuals with at least one copy of the DAT 9-repeat allele, carriers of the BDNF Met allele exhibited significantly lower Neuroticism scores than noncarriers. This interaction was also observed for TPQ Harm Avoidance, a personality dimension related to Neuroticism. Our results support the notion that allelic variation at the BDNF locusFin interaction with other gene variantsFinfluences anxietyand depression-related personality traits.

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Section: Discussionmentioning

confidence: 99%

Interaction between BDNF Val66Met and Dopamine Transporter Gene Variation Influences Anxiety-Related Traits

Hünnerkopf

Strobel²,

Gutknecht

et al. 2007

Neuropsychopharmacol

117

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“…In rat primary auditory neurons, transient TH production is concurrent with the development of hearing (Trigueiros-Cunha et al, 2003). When grown in culture, embryonic rat and human cerebral cortical cells, which do not produce TH in vivo, are capable of TH expression (Iacovitti et al, 1987;Theofilopoulos et al, 2001). Cells transiently immunoreactive for TH are present in the developing rodent CNS in a variety of areas in addition to the cerebral cortex, including the inferior colliculus (Jaeger and Joh, 1983), medial geniculate nucleus (Nagatsu et al, 1996), cerebellar Purkinje cells (Hess and Wilson, 1991), limbic forebrain (Verney et al, 1988), and anterior olfactory nucleus (Nagatsu et al, 1990).…”

Section: Discussionmentioning

confidence: 99%

Neurochemical characterization of tyrosine hydroxylase-immunoreactive interneurons in the developing rat cerebral cortex

et al. 2008

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Understanding the development of cortical interneuron phenotypic diversity is critical because interneuron dysfunction has been implicated in several neurodevelopmental disorders. Here, tyrosine hydroxylase (TH)-immunoreactive neurons in the developing and adult rat cortex were characterized in light of findings regarding interneuron neurochemistry and development. Cortical THimmunoreactive neurons were first observed two weeks postnatally and peaked in number three weeks after birth. At subsequent ages, the number of these cell profiles was gradually reduced, and they were seen less frequently in adults. No DNA fragmentation or active caspase 3 was observed in cortical TH cells at any age examined, eliminating cell death as an explanation for the decrease in cell number. Although cortical TH cells reportedly fail to produce subsequent catecholaminergic enzymes, we found that the majority of these cells at all ages contained phosphorylated TH, suggesting that the enzyme may be active and producing L-DOPA as an end-product. Morphological criteria and colocalization of some TH cells with glutamic acid decarboxylase suggests that these cells are interneurons. Previously, parvalbumin, somatostatin, and calretinin were demonstrated in nonoverlapping subsets of interneurons. Cortical TH neurons colocalized with calretinin but not with parvalbumin or somatostatin. These findings suggest that the transitory increase in TH cell number is not due to cell death but possibly due to alterations in the amount of detectable TH present in these cells, and that at least some cortical TH-producing interneurons belong to the calretinin-containing subset of interneurons that originate developmentally in the caudal ganglionic eminence.

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“…Subsequent studies have shown that it can also act on other neuronal types (see [7]). GDNF has been shown to induce the dopamine synthetic enzyme, tyrosine hydroxylase (TH), in fetal human and rat cortical cultures (Table 1) [8].…”

Section: Effects Of Gdnf In Vitromentioning

confidence: 99%

“…Increases Tyrosine Hydroxylase expression [8] Promotes survival of mesencephalic cultures [6,9] Promotes morphological differentiation [10] Protects from MPP+ neurotoxicity [12,13] Protects from 6-OHDA neurotoxicity [11] Decreases apoptosis [14,15,16] Protects from LPS neurotoxicity [17] …”

Section: Conflict Of Interestmentioning

confidence: 99%

Neurotrophic factors for the treatment of Parkinson's disease

Sullivan

Toulouse

2011

Cytokine & Growth Factor Reviews

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Parallel induction of the formation of dopamine and its metabolites with induction of tyrosine hydroxylase expression in foetal rat and human cerebral cortical cells by brain-derived neurotrophic factor and glial-cell derived neurotrophic factor

Cited by 38 publications

References 62 publications

Interaction between BDNF Val66Met and Dopamine Transporter Gene Variation Influences Anxiety-Related Traits

Interaction between BDNF Val66Met and Dopamine Transporter Gene Variation Influences Anxiety-Related Traits

Neurochemical characterization of tyrosine hydroxylase-immunoreactive interneurons in the developing rat cerebral cortex

Neurotrophic factors for the treatment of Parkinson's disease

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