Parallel manifestation of Crohn’s disease and acute pericarditis: a report of two cases

Stasinopoulou, Panagiota; Kaziani, Aikaterini; Mantzaris, Gerassimos J.; Roussos, Anastasios; Skoutelis, Athanasios

doi:10.1007/s00384-007-0327-6

Cited by 6 publications

(6 citation statements)

References 7 publications

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“…The incidence of extraintestinal manifestations ranges between 6%-47% 20-23. Although concomitance of IBDs with cardiac disorders is rare, sporadic cases of complication with pericardial effusion, pericarditis, myocarditis, endocarditis, cardiomyopathy, thromboembolic events, conduction defects and drug use have been reported 3,24. On the other hand, early atherosclerosis and thromboembolic events, and as a consequence cardiovascular mortality are known to increase in cases with IBD 25-28.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of QT and P Wave Dispersion and Mean Platelet Volume among Inflammatory Bowel Disease Patients

Doğan¹,

Soylu²,

Eren³

et al. 2011

Int. J. Med. Sci.

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Background: In inflammatory bowel disease (IBD) number of thromboembolic events are increased due to hypercoagulupathy and platelet activation. Increases in mean platelet volume (MPV) can lead to platelet activation, this leads to thromboembolic events and can cause acute coronary syndromes. In IBD patients, QT-dispersion and P-wave dispersion are predictors of ventricular arrhythmias and atrial fibrilation; MPV is accepted as a risk factor for acute coronary syndromes, we aimed at evaluating the correlations of these with the duration of disease, its localization and activity.Methods: The study group consisted of 69 IBD (Ulcerative colitis n: 54, Crohn's Disease n:15) patients and the control group included 38 healthy individuals. Disease activity was evaluated both endoscopically and clinically. Patients with existing cardiac conditions, those using QT prolonging medications and having systemic diseases, anemia and electrolyte imbalances were excluded from the study. QT-dispersion, P-wave dispersion and MPV values of both groups were compared with disease activity, its localization, duration of disease and the antibiotics used.Results: The P-wave dispersion values of the study group were significantly higher than those of the control group. Duration of the disease was not associated with QT-dispersion, and MPV levels. QT-dispersion, P-wave dispersion, MPV and platelet count levels were similar between the active and in mild ulcerative colitis patients. QT-dispersion levels were similar between IBD patients and the control group. No difference was observed between P-wave dispersion, QT-dispersion and MPV values; with regards to disease duration, disease activity, and localization in the study group (p>0.05).Conclusions: P-wave dispersion which is accepted as a risk factor for the development of atrial fibirilation was found to be high in our IBD patients. This demonstrates us that the risk of developing atrial fibrillation may be high in patients with IBD. No significant difference was found in the QT-dispersion, and in the MPV values when compared to the control group.

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Section: Discussionmentioning

confidence: 99%

Evaluation of QT and P Wave Dispersion and Mean Platelet Volume among Inflammatory Bowel Disease Patients

Doğan¹,

Soylu²,

Eren³

et al. 2011

Int. J. Med. Sci.

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“…Cardiac involvement is rare, but it can worsen the prognosis of patients with inflammatory bowel disease (IBD) [2]. Perimyocarditis, valvular damage and venous thrombosis are the most common cardiovascular manifestations in IBD patients [3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

A study on QT interval in patients affected with inflammatory bowel disease without cardiac involvement

et al. 2010

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Cardiac involvement has been studied quite extensively in patients affected by inflammatory bowel disease but, as of now, there is no data regarding QT alterations which are well known to be linked to the risk of dangerous arrhythmias. In this study, QT parameters were digitally measured on standard 12-lead ECG in a population of 20 patients affected by inflammatory bowel disease (IBD), with no prior (recent or old) history of cardiac disease and no evidence of electrolyte imbalance. Eighteen healthy subjects formed the control group. The results obtained using non-parametric statistics (Wilcoxon-Mann-Whitney test) showed that heart rate corrected QT interval (QTc) and QTc dispersion (QTc d) values were both significantly higher in IBD patients than in the control group. QTc rank sum values in patients affected by inflammatory bowel disease were 469 versus 311 in healthy subjects (Z = 1.939, p = 0.0263). QTc d rank sum values were 460 in IBD patients versus 320 in controls (Z = 1.686 with p = 0.0459). Regardless of the cause of these QT alterations, it appears evident that accurate monitoring of QT parameters is required in these patients who often experience electrolyte disturbances and who may, in some cases, be undergoing treatment with potentially cardiotoxic drugs such as infliximab.

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“…Previously two studies including three patients, pericarditis preceded the onset of Crohn's disease. [ 12 13 ] Furthermore, Manomohan et al . reported an adolescent with severe pericarditis with flare-up of Crohn's disease.…”

Section: Discussionmentioning

confidence: 99%

Recurrent pericarditis in an adolescent with Crohn's colitis

2020

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Extraintestinal manifestations are common complications of inflammatory bowel disease (IBD), whereas the recurrent pericarditis during remission of Crohn's disease is rarely reported. Chest pain developed in a 13-year-old adolescent male who had a history of Crohn's colitis since 9 years of age and was in remission for 4 years after treatment with infliximab, adalimumab, and vedolizumab. Physicians should be aware of the pericardial involvement in patients with a history of IBD. The literature on pericardial involvement in Crohn's disease is reviewed with emphasis on the management of recurrent pericardial effusion in the pediatric age group.

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Parallel manifestation of Crohn’s disease and acute pericarditis: a report of two cases

Cited by 6 publications

References 7 publications

Evaluation of QT and P Wave Dispersion and Mean Platelet Volume among Inflammatory Bowel Disease Patients

Evaluation of QT and P Wave Dispersion and Mean Platelet Volume among Inflammatory Bowel Disease Patients

A study on QT interval in patients affected with inflammatory bowel disease without cardiac involvement

Recurrent pericarditis in an adolescent with Crohn's colitis

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