Parallel roles of neuroinflammation in feline and human epilepsies

Binks, Sophie; Lamquet, Simon; Meurs, Alfred; Irani, Sarosh; Pákozdy, Ákos

doi:10.1016/j.tvjl.2022.105912

The Veterinary Journal

2022

DOI: 10.1016/j.tvjl.2022.105912

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Parallel roles of neuroinflammation in feline and human epilepsies

Sophie Binks

Simon Lamquet

Alfred Meurs

et al.

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Cited by 3 publications

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“…Five different neural antibodies have been described in dogs up to now including this case report (NMDAR1, GFAP, GAD65, IgLON5, GABA-A receptor antibodies). Yet their clinical impact is not always as clear as for LGI1 antibodies in cats with limbic encephalitis ( 5 , 6 ), and more research is necessary to explore disease associations. This is especially important considering the frequent occurrence and the efforts and challenges of the treatment of status epilepticus in dogs ( 7 ), and the potential for treatment with anti-inflammatory or immunosuppressive drugs.…”

mentioning

confidence: 99%

Editorial: Epilepsy in veterinary science

Fischer

Volk

2023

Front. Vet. Sci.

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mentioning

confidence: 99%

Editorial: Epilepsy in veterinary science

Fischer

Volk

2023

Front. Vet. Sci.

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Medicinal plants for epileptic seizures: Phytoconstituents, pharmacology and mechanisms revisited

He,

Chen,

Yang

et al. 2024

Journal of Ethnopharmacology

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Canine idiopathic generalized tremor syndrome, immune-mediated?

Kajin,

Meyerhoff,

Meller

et al. 2024

Front. Vet. Sci.

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Idiopathic generalized tremor syndrome is a disorder characterized by an acute onset of full-body tremors, sometimes accompanied by vestibulo-cerebellar signs, that is responsive to treatment with corticosteroids. Although considered to have an overall good outcome, relapsing and persistent mild clinical signs have been described. So far, little is known about the etiopathology of this syndrome, but it is believed to have an immune-mediated origin. In human medicine, description of numerous autoantibodies involved in certain non-infectious neurologic disorders has revolutionized understanding of their pathophysiology, diagnosis and treatment. In this multicenter retrospective study, we aimed to describe the clinical signs, course, and outcome of dogs with idiopathic generalized tremor syndrome and correlate potential findings with the presence or absence of autoantibodies associated with autoimmune cerebellar syndromes in humans. Information regarding signalment, history, clinical signs, laboratory findings, diagnostic imaging and testing for regional infectious diseases was gathered and the remaining serum and CSF samples were then analyzed for neural antibodies against targets associated with autoimmune encephalitic diseases of humans. Thirty-three dogs were included, and screening for neural antibodies was performed in 30 of those dogs. The analysis showed an increased titer of mGluR1 antibodies in two dogs, GFAP and later in the course of disease mGluR1 antibodies in one dog and an increase in unspecific autoantibodies which could not be further classified in two dogs. Dogs with detectable neural autoantibodies always had cerebrospinal fluid abnormalities in the form of a pleocytosis, with or without increased protein concentration, and tended to present with hyperthermia, potentially indicating a more severe clinical form of idiopathic generalized tremor syndrome in these cases. In conclusion, idiopathic generalized tremor syndrome is proposed to be an immune-mediated disorder potentially mediated by neural autoantibodies in a subgroup of dogs.

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Parallel roles of neuroinflammation in feline and human epilepsies

Cited by 3 publications

References 129 publications

Editorial: Epilepsy in veterinary science

Editorial: Epilepsy in veterinary science

Medicinal plants for epileptic seizures: Phytoconstituents, pharmacology and mechanisms revisited

Canine idiopathic generalized tremor syndrome, immune-mediated?

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