This study empirically compares two approaches to parallel 3-D OSEM that differ as to whether calculations are assigned to nodes by projection number or by transaxial plane number. For projection space decomposition (PSD), the forward projection is completely parallel, but backprojection requires a slow image synchronization. For image space decomposition (ISD), the communication associated with forward projection can be overlapped with calculation, and the communication associated with backprojection is more efficient. To compare these methods, an implementation of 3-D OSEM for three PET scanners is developed that runs on an experimental 9-node, 18-processor cluster computer. For selected benchmarks, both methods exhibit speedups in excess of eight or nine nodes, and comparable performance for the tested range of cluster sizes.Index Terms-Biomedical image processing, image reconstruction, parallel algorithms, parallel processing, positron emission tomography.