Paralytic shellfish poisoning due to ingestion of Gymnodinium catenatum contaminated cockles – Application of the AOAC HPLC Official Method

Rodrigues, Susana Margarida; Carvalho, Mamede de; Mestre, Tiago; Ferreira, Joaquim J.; Coelho, Miguel; Peralta, Ana Rita; Vale, Paulo

doi:10.1016/j.toxicon.2012.01.004

Cited by 39 publications

(25 citation statements)

References 23 publications

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“…The diagnosis of paralytic shellfish poisoning is almost always made clinically, but can be confirmed by measurement of saxitoxin levels either in the shellfish meat or the patient’s urine or serum 11. In our case series, the diagnosis was based on clinical presentation, geographic location, and temporal association with eating bivalves from a beach with known toxic levels of saxitoxin.…”

Section: Discussionmentioning

confidence: 89%

Paralytic Shellfish Poisoning: A Case Series

Hurley¹,

Wolterstorff²,

MacDonald³

et al. 2014

WestJEM

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We describe a case series of seven patients presenting to an emergency department with symptoms of paralytic shellfish poisoning. They developed varying degrees of nausea, vomiting, diarrhea, weakness, ataxia and paresthesias after eating mussels harvested from a beach near their resort. Four patients were admitted to the hospital, one due to increasing respiratory failure requiring endotracheal intubation and the remainder for respiratory monitoring. All patients made a full recovery, most within 24 hours. The ability to recognize and identify paralytic shellfish poisoning and manage its complications are important to providers of emergency medicine.

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Section: Discussionmentioning

confidence: 89%

Paralytic Shellfish Poisoning: A Case Series

Hurley¹,

Wolterstorff²,

MacDonald³

et al. 2014

WestJEM

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“…It is more sensitive than the MBA which is regarded as the official regulatory method in most of the world with the detection limit of 200 ng/ml (40 μg STX/100 g shellfish) (Botana, 2008;Etheridge, 2010;Cusick and Sayler, 2013). And the LOD of the AOAC HPLC official method for STX is about 1.2 ng/ml was also higher than that of cell-based biosensor (Rodrigues et al, 2012). The information of different cell-based assays was listed in Table 1.…”

Section: Detection Of Saxitoxin (Stx) In Spiked Mussel Extractsmentioning

confidence: 99%

An improved sensitive assay for the detection of PSP toxins with neuroblastoma cell-based impedance biosensor

Zou

Wang

et al. 2015

Biosensors and Bioelectronics

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“…Rising water temperature and eutrophication were pointed out as the most significant factors in this increase [2]. HABs have a severe impact on the economy and human health, because phycotoxins may travel along the food chain, contaminating edible shellfish, resulting in intoxication incidents [3,4,5,6,7]. These phycotoxins can be classified as being either hydrophilic or lipophilic, with typical molecular weights (MW) of 500 Da and 600 Da, respectively [8].…”

Section: Introductionmentioning

confidence: 99%

New Invertebrate Vectors for PST, Spirolides and Okadaic Acid in the North Atlantic

et al. 2013

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The prevalence of poisoning events due to harmful algal blooms (HABs) has declined during the last two decades through monitoring programs and legislation, implemented mainly for bivalves. However, new toxin vectors and emergent toxins pose a challenge to public health. Several locations on the Portuguese coast were surveyed between 2009 and 2010 for three distinct biotoxin groups [saxitoxin (PST), spirolide (SPX) and okadaic acid (OA)], in 14 benthic species of mollusks and echinoderms. Our main goals were to detect new vectors and unravel the seasonal and geographical patterns of these toxins. PSTs were analyzed by the Lawrence method, SPXs by LC-MS/MS, and OA by LC-MS/MS and UPLC-MS/MS. We report 16 new vectors for these toxins in the North Atlantic. There were differences in toxin contents among species, but no significant geographical or seasonal patterns were found. Our results suggest that legislation should be adjusted to extend the monitoring of marine toxins to a wider range of species besides edible bivalves.

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Paralytic shellfish poisoning due to ingestion of Gymnodinium catenatum contaminated cockles – Application of the AOAC HPLC Official Method

Cited by 39 publications

References 23 publications

Paralytic Shellfish Poisoning: A Case Series

Paralytic Shellfish Poisoning: A Case Series

An improved sensitive assay for the detection of PSP toxins with neuroblastoma cell-based impedance biosensor

New Invertebrate Vectors for PST, Spirolides and Okadaic Acid in the North Atlantic

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