Using high-precision sensors to monitor and predict the deformation trend of supertall buildings is a hot research topic for a long time. And in terms of deformation trend prediction, the main way to realized deformation trend prediction is the deep learning algorithm, but the accuracy of prediction result needs to be improved. To solve the problem described above, firstly, based on the conditional deep belief network (CDBN) model, the levenberg-marquardt (LM) was used to optimize the CDBN model; the LM-CDBN model has been constructed. Then taking CITIC tower, the tallest building in Beijing as the research object, the real-time monitoring data of the shape acceleration array (SAA) as an example, we used LM-CDBN model to analyse and predict the building deformation. Finally, to verify the accuracy and robustness of LM-CDBN model, the prediction results of the LM-CDBN model are compared with the prediction results of the CDBN model, the extreme learning machine (ELM) model, and the unscented Kalman filter-support vector regression (UKF-SVR) model, and we evaluated the result from three aspects: training error, fitness, and stability of prediction results. The results show that the LM-CDBN model has higher precision and fitting degree in the prediction of deformation trend of supertall buildings. And the MRE, MAE, and RMSE of the LM-CDBN model prediction results are only 0.0060, 0.0023mm, and 0.0031mm, and the prediction result was more in line with the actual deformation trend.