Parameter estimation and mathematical modeling of the diffusion process of a benzoic acid infused Fricke gel dosimeter

Vedelago, José; Quiroga, Andrés; Triviño, Sebastián; Mattea, Facundo; Valente, M.

doi:10.1016/j.apradiso.2019.04.035

Cited by 13 publications

(5 citation statements)

References 36 publications

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“…Based on the measured dose-response curves, the R2 sensitivity is higher than the R1 sensitivity within the dose ranges of 0-1000 cGy. This result is in good agreement with previous works conducted on ferrous benzoic xylenol orange gel dosimeter (FBXG) [20,41].…”

Section: Discussionsupporting

confidence: 93%

“…Further, the measured R2 sensitivity in the present work was 0.092 ± 0.004 s − 1 Gy − 1 which is 2.55 times higher than the value reported in Eyadeh et al study [40]. The addition of BA to Fricke gel dosimeter leads to an increase in dose-response sensitivity of gel dosimeter, as stated in other studies [41]. Based on the measured dose-response curves, the R2 sensitivity is higher than the R1 sensitivity within the dose ranges of 0-1000 cGy.…”

Section: Discussioncontrasting

confidence: 46%

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Evaluation of ferrous benzoic methylthymol-blue gel as a dosimeter via magnetic resonance imaging

et al. 2020

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Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 46%

Evaluation of ferrous benzoic methylthymol-blue gel as a dosimeter via magnetic resonance imaging

et al. 2020

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“…The diffusion coefficient was determined when dn/dt was multiplied by the factor 0.212 ( Figure 8 b), and it was calculated to 0.238 mm 2 h −1 . Besides, the diffusion within the FPX@PDMS pellets could be also corrected according to the mathematical model based on inverse problem techniques proposed by Vedelago et al [ 41 ]. However, a detailed analysis is beyond the scope of this work.…”

Section: Resultsmentioning

confidence: 99%

Low-Diffusion Fricke Gel Dosimeters with Core-Shell Structure Based on Spatial Confinement

Zhang

Zeng

et al. 2021

Materials

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The diffusion of ferric ions is an important challenge to limit the application of Fricke gel dosimeters in accurate three-dimensional dose verification of modern radiotherapy. In this work, low-diffusion Fricke gel dosimeters, with a core-shell structure based on spatial confinement, were constructed by utilizing microdroplet ultrarapid freezing and coating technology. Polydimethylsiloxane (PDMS), with its excellent hydrophobicity, was coated on the surface of the pellets. The concentration gradient of the ferric ion was realized through shielding half of a Co-60 photon beam field size, and ion diffusion was measured by both ultraviolet-visible spectrophotometry and magnetic resonance imaging. No diffusion occurred between the core-shell pellets, even at 96 h after irradiation, and the diffusion length at the irradiation boundary was limited to the diameter (2–3 mm) of the pellets. Furthermore, Monte Carlo calculations were conducted to study dosimetric properties of the core-shell dosimeter, which indicated that a PDMS shell hardly affected the performance of the dosimeter.

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“…By performing a comparison with a polymer gel, the identification was made that NC-RFG improved the effects of sensitivity degradation caused by oxygen inhibiting the polymerisation processes. Fricke gel requires the analysis of the diffusion of products after irradiation (Coulaud et al 2019, Vedelago et al 2019; however, NC-RFG uses nanoclay as a gelling agent to improve the effects of diffusion and to spatially retain dose data. The characteristics of NC-RFG are suitable to dosimetry in HDR brachytherapy, thereby resulting in improved accuracy of dosimetry as well as expansion of the measurement area.…”

Section: Discussionmentioning

confidence: 99%

Verification of dose distribution in high-dose-rate brachytherapy using a nanoclay-based radio-fluorogenic gel dosimeter

et al. 2020

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Dose distributions have become more complex with the introduction of image-guided brachytherapy in high-dose-rate (HDR) brachytherapy treatments. Therefore, to correctly execute HDR, conducting a quality assurance programme for the remote after-loading system and verifying the dose distribution in the patient treatment plan are necessary. The characteristics of the dose distribution of HDR brachytherapy are that the dose is high near the source and rapidly drops when the distance from the source increases. Therefore, a measurement tool corresponding to the characteristic is required. In this study, using an Iridium-192 (Ir-192) source, we evaluated the basic characteristics of a nanoclay-based radio-fluorogenic gel (NC-RFG) dosimeter that is a fluorescent gel dosimeter using dihydrorhodamine 123 hydrochloride as a fluorescent probe. The two-dimensional dose distribution measurements were performed at multiple source positions to simulate a clinical plan. Fluorescence images of the irradiated NC-RFG were obtained at a high resolution (0.04 mm pixel–1) using a gel scanner with excitation at 465 nm. Good linearity was confirmed up to a dose range of 100 Gy without dose rate dependence. The dose distribution measurement at the five-point source position showed good agreement with the treatment planning system calculation. The pass ratio by gamma analysis was 92.1% with a 2%/1 mm criterion. The NC-RFG dosimeter demonstrates to have the potential of being a useful tool for quality assurance of the dose distribution delivered by HDR brachytherapy. Moreover, compared with conventional gel dosimeters such as polymer gel and Fricke gel dosimeters it solves the problems of diffusion, dose rate dependence and inhibition of oxygen-induced reactions. Furthermore, it facilitates dose data to be read in a short time after irradiation, which is useful for clinical use.

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Parameter estimation and mathematical modeling of the diffusion process of a benzoic acid infused Fricke gel dosimeter

Cited by 13 publications

References 36 publications

Evaluation of ferrous benzoic methylthymol-blue gel as a dosimeter via magnetic resonance imaging

Evaluation of ferrous benzoic methylthymol-blue gel as a dosimeter via magnetic resonance imaging

Low-Diffusion Fricke Gel Dosimeters with Core-Shell Structure Based on Spatial Confinement

Verification of dose distribution in high-dose-rate brachytherapy using a nanoclay-based radio-fluorogenic gel dosimeter

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