Application of adaptive neuro fuzzy inference system (ANFIS)-based particle swarm optimization (PSO) algorithm to the problem of aerodynamic modeling and optimal parameter estimation for aircraft has been addressed in this chapter. The ANFIS-based PSO optimizer constitutes the aircraft model in restricted sense capable of predicting generalized force and moment coefficients employing measured motion and control variables only, without formal requirement of conventional variables or their time derivatives. It has been shown that such an approximate model can be used to extract equivalent stability and control derivatives of a rigid aircraft.