Parameters influencing the acquisition of competence for metamorphosis in imaginal disks of Drosophila

Mindek, G.; Nöthiger, Rolf

doi:10.1016/0022-1910(73)90039-5

Cited by 33 publications

(4 citation statements)

References 14 publications

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“…The existence of differences in the responsiveness to metaZoology: Schweizer and Bodenstein morphosis by different discs, discs of different age, and even by different regions within one disc, has been known for a long time (3)(4)(5)(12)(13)(14)(15)(16). Bodenstein (4) interpreted his observations by assuming that different hormone titers are required for the induction of imaginal differentiation in the different kinds, ages, and regions of discs.…”

Section: Resultsmentioning

confidence: 99%

“…Thus, the discs acquire the competence to metamorphose during their growth period, and this growth is under the control of the ring gland hormone (4). Now, Mindek and N6thiger (5) In this investigation, we will present evidence that the competence of a mature imaginal disc to undergo metamorphosis is not a stable nor absolute condition. If imaginal discs are cultured in vivo in adult male flies, they are placed in an environment that is completely restrictive for their further growth and differentiation (4).…”

mentioning

confidence: 93%

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Aging and its relation to cell growth and differentiation in Drosophila imaginal discs: developmental response to growth restricting conditions.

Schweizer¹,

Bodenstein²

1975

Proc. Natl. Acad. Sci. U.S.A.

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The development of Drosophila organ discs can be arrested by culturing them in adult male flies. These aged discs lose some of their differentiation competence and form incomplete imaginal structures. The more advanced the aging, the greater the loss of competence. Discs made to differentiate prematurely show deficiencies similar to aged discs. The age-induced defects can be repaired in a larval milieu. Special hormonal conditions, but not cell multiplication, are apparently involved in the recovery process. The action of hormones as controlling mechanisms in the growth and differentiation of Drosophila development has been well established. Moreover, it has been known for a long time that the imaginal discs, i.e., the anlagen of the future adult organs, metamorphose and differentiate under the influence of a hormone released by the ring gland at the end of larval life; they finally form the various cuticular structures that make up the adult integument (1). In the interaction between hormone and tissues, two parameters are of particular significance: the hormone titer and the readiness of the target tissues to respond to the hormonal demands in a characteristic manner. Different developmental stages of a tissue can respond differently to the same hormonal environment. For instance, very young imaginal discs will continue to grow in the humoral milieu of a late larva, whereas the hormones of a larva of the same age will induce imaginal differentiation in older discs. Discs of intermediate age transplanted prematurely into metamorphosing hosts may exhibit partial imaginal differentiation (2). To acquire competence to metamorphose a young disc need not undergo its development solely in a larval environment, even though this is of course its norm. By appropriate experimental manipulation, a disc can become competent by developing in a pupal and/or pharate adult host. Mindek (3) transplanted incompetent eye-antenna discs from newly hatched larvae into older larvae ready to pupate. After metamorphosis of the host the discs were still undifferentiated, thus showing their incompetence to respond to the metamorphosis factors. Yet they had grown in their new host environment from pupation to emergence of the fly, to the size of a disc equivalent to an older larval stage. Such discs were transplanted for a second time into larvae ready to pupate. They were dissected after the emergence of the second host and found now to have differentiated to imaginal completion, exhibiting all their organ specific adult structures.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 93%

Aging and its relation to cell growth and differentiation in Drosophila imaginal discs: developmental response to growth restricting conditions.

Schweizer¹,

Bodenstein²

1975

Proc. Natl. Acad. Sci. U.S.A.

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“…They are first morphologically recognizable as small cell clusters within the larval ectoderm at the end of embryonic life [Madhavan and Schneiderman, 1977;Bate and Martinez-Arias, 19911. During larval life, the imaginal discs grow by cell division and acquire, in a spatial and temporal sequence, the capacity to differentiate into their respective adult integumental structures [Mindek and Nothiger, 1973;Schneiderman, 1974, 1975;Sanchez and Granadino, 19921. Finally, during development in the pupa, they differentiate the adult cuticular patterns of the head, the thorax, appendages, and genitalia.…”

Section: Introductionmentioning

confidence: 99%

Tumor suppression in Drosophila is causally related to the function of the lethal(2)tumorous imaginal discs gene, a dnaJ homolog

et al. 1995

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The Drosophila melanogaster tumor suppressor gene lethal(2)tumorous imaginal discs (l(2)tid) causes in homozygotes malignant growth of cells of the imaginal discs and the death of the mutant larvae at the time of puparium formation. We describe the molecular cloning of the l(2)tid+ gene and its temporal expression pattern in the wild-type and mutant alleles. Germ line rescue of the tumor phenotype was achieved with a 7.0 kb Hindlll-fragment derived from the polytene chromosome band 59F5. The l(2)tid+ gene spans approximately 2.5 kb of genomic DNA. The protein coding region, 1,696 bps long, is divided by an intron into two exons. The predicted Tid56 protein contains 518 amino acids and possesses a theoretical molecular weight of 56 kDa. It shows significant homology to all known DnaJ related proteins from bacteria, yeast, and man. The possible function of the Tid56 protein in tumor suppression is delineated.

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“…As observed in Drosophila melanogaster, the competency of imaginal discs to differentiate depends on the number of cell divisions that have occurred (Mindek and Nothiger, 1973). During the last larval instar of lepidopterans, the imaginal discs have a rapid rate of growth due to an increased rate of cellular proliferation that is stimulated by the action of 20-hydroxyecdysone (20E) (cf.…”

Section: Introductionmentioning

confidence: 99%

“Reduced appendage”: A mutation affecting development of pupal and adult appendages of the moth, Plodia interpunctella

Shirk

Ogren

1994

Arch Insect Biochem Physiol

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A mutant that results in the reduced length of pupal and adult appendages was isolated from a laboratory colony of the lndianmeal moth, Plodia interpunctella (Hubner). "Reduced appendage" (rda) was determined to be an autosomal recessive mutation that affects the development of pupal and adult appendages during the larval/pupal molt. The rda mutation had no observed effect on the larval phenotype. After pupation, the appendages of rda were reduced in size as cornpared with wild-type. In addition, unsclerotized cuticle underlying the pupal appendages was exposed and the establishment of the boundary between the unsclerotized and sclerotized pupal abdominal cuticle appeared normal even though the imaginal discs of rda did not evaginate normally. This demonstrates that rda affects only imaginal discs and that the morphogenesis of structures that were not derived from the imaginal discs were not dependent on interactions with evagination of imaginal discs. Although the rda phenotype resulted in shorter antennae, mouth parts, legs, and wings in pupae and adults, the mutation did not affect the number of cells comprising the imaginal discs or the pupal appendages.Cell counts showed that forewing imaginal discs and pupal forewings from the rda mutants contained the same number of cells as did the imaginal discs and wings from the wild-type strain. Thus, rda appears to affect processes related to disc evagination and not cell proliferation. o 1994 ~i t e y -~i s s , Inc.*

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Parameters influencing the acquisition of competence for metamorphosis in imaginal disks of Drosophila

Cited by 33 publications

References 14 publications

Aging and its relation to cell growth and differentiation in Drosophila imaginal discs: developmental response to growth restricting conditions.

Aging and its relation to cell growth and differentiation in Drosophila imaginal discs: developmental response to growth restricting conditions.

Tumor suppression in Drosophila is causally related to the function of the lethal(2)tumorous imaginal discs gene, a dnaJ homolog

“Reduced appendage”: A mutation affecting development of pupal and adult appendages of the moth, Plodia interpunctella

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