Parameters of body composition do not predict survival in patients with multiple myeloma undergoing autologous stem cell transplantation

Barajas Ordonez, Felix; Wolleschak, Denise; Zeller, Yannic; Hinnerichs, Mattes; Rodríguez-Feria, Pablo; Aghayev, Anar; Mikusko, Martin; Borggrefe, Jan; Mougiakakos, Dimitrios; Surov, Alexey

doi:10.1080/10428194.2024.2319226

Leukemia & Lymphoma

2024

DOI: 10.1080/10428194.2024.2319226

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Parameters of body composition do not predict survival in patients with multiple myeloma undergoing autologous stem cell transplantation

Felix Barajas Ordonez,

Denise Wolleschak,

Yannic Zeller

et al.

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2024

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Myosteatosis in multiple myeloma: a key determinant of survival beyond sarcopenia

Diallo,

Blessing,

Ihorst

et al. 2024

Skeletal Radiol

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Objective Fatty infiltration of skeletal muscle (Myosteatosis) is associated with increased frailty, decreased muscle and mobility function, which seems fairly prevalent in multiple myeloma (MM) patients. This study aimed to determine the prognostic value of myosteatosis assessed by CT for progression-free survival (PFS) and overall survival (OS). Materials and methods This IRB-approved cohort study included patients with newly diagnosed MM who were treated at a single university hospital and received CT at baseline. Geriatric assessment was performed via International Myeloma Working Group frailty score and Revised Myeloma Comorbidity Index. Myosteatosis was determined through measurement of paravertebral muscle radiodensity. Statistical analyses included uni- and multivariable Cox proportional hazard models and the Kaplan–Meier-method. Results A total of 226 newly diagnosed MM patients (median age: 65 years [range: 29–89], 63% males, mean BMI: 25 [14–42]) were analyzed. The prevalence of myosteatosis was 51%. Muscle radiodensity was significantly decreased in individuals with International Staging System stage III vs. I (p < 0.001), indicating higher fatty muscle infiltration in patients with advanced disease. Both PFS and OS were significantly decreased in patients with myosteatosis (PFS: median 32.0 months (95% CI 20.5.5–42.2) vs. 66.4 months without myosteatosis (95% CI 42.5-not reached), p < .001); OS: median 58.6 (95% CI 51.3—90.2) vs. not reached, p < .001). Myosteatosis remained an independent predictor of OS in multivariable analyses (HR: 1.98; 95%-CI: 1.20–3.27). Conclusion Myosteatosis seems fairly prevalent in patients with newly diagnosed MM and associated with impaired overall survival. Prospective clinical trials are required to better understand the role of myosteatosis in MM patients.

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Myosteatosis in multiple myeloma: a key determinant of survival beyond sarcopenia

Diallo,

Blessing,

Ihorst

et al. 2024

Skeletal Radiol

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Parameters of body composition do not predict survival in patients with multiple myeloma undergoing autologous stem cell transplantation

Cited by 1 publication

References 23 publications

Myosteatosis in multiple myeloma: a key determinant of survival beyond sarcopenia

Myosteatosis in multiple myeloma: a key determinant of survival beyond sarcopenia

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