Parameters of high-density lipoproteins in patients with arterial hypertension in combination with other components of metabolic syndrome

Ozerova, I. N.; Perova, N. V.; Щельцына, Н. В.; Мамедов, М. Н.

doi:10.1007/s10517-007-0100-4

Cited by 14 publications

(14 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, HDL from patients with malaria ( 117 ) and uremic patients on hemodialysis ( 91 ) displays elevated content of triglyceride, whereas HDL from patients with psoriasis is depleted in cholesteryl ester ( 92 ). Cytokine-induced increase in the activity of CETP paralleled by decreases in the activities of hepatic lipase, LPL, and LCAT can underlie hypertriglyceridemia, altered phospholipid composition characterized by elevated content of LPC and PE and diminished content of PC ( 90 ). Consistent with these data, HDL obtained from patients on maintenance hemodialysis contained reduced amounts of phospholipid and elevated amounts of lysophospholipid ( 91 ).…”

Section: Cholesteryl Esters and Triglyceridesmentioning

confidence: 99%

See 1 more Smart Citation

Unraveling the complexities of the HDL lipidome

Kontush

Lhomme

Chapman

2013

Journal of Lipid Research

314

247

View full text Add to dashboard Cite

This article is available online at http://www.jlr.org For many years, HDL lipids were predominantly characterized in terms of the content of their major classes, notably phospholipids, unesterifi ed (free) sterols (predominantly cholesterol), cholesteryl esters, and triglycerides. Cholesterol is the most characteristic component of the HDL lipidome as, in the form of HDL-cholesterol, it represents a major independent negative risk factor for cardiovascular disease (see other reviews in this Thematic Series). It is not cholesterol, however, but phospholipids that quantitatively predominate in the HDL lipidome, accounting, together with sphingomyelin (SM), for 40-60 wt% of total lipid, with lesser proportions of cholesteryl esters (30-40%), triglycerides (5-12%), and free cholesterol (5-10%). Structurally, individual HDL lipid classes fulfi ll distinct functions; phospholipids constitute the surface lipid monolayer of HDL, whereas cholesteryl esters and triglycerides form the hydrophobic lipid core. Unesterifi ed sterols are predominantly located to the surface monolayer, partially penetrating the core.Recent technological advances in mass spectrometry (MS) have enabled application of this powerful technique to provide a detailed identifi cation and quantifi cation of individual molecular species of lipids in the framework of the fi eld known as lipidomics. Application of this approach to plasma lipoproteins has revealed complex profi les consisting of hundreds of molecular lipid species that have been quantifi ed in major lipoprotein classes, including HDL (reviewed in Refs. 1-3 High density lipoproteins (HDL) are small, dense, protein-rich particles compared with other plasma lipoprotein classes. Despite the elevated abundance of multiple structural and functional proteins in HDL particles (see other reviews in this Thematic Series), roughly half of total HDL mass is accounted for by lipid components.

show abstract

Section: Cholesteryl Esters and Triglyceridesmentioning

confidence: 99%

“…On the other hand, HDL SM is elevated in patients with isolated arterial hypertension ( 90 ) and with psoriasis ( 92 ). Interestingly, SM enrichment in HDL may selectively inhibit generation of specifi c molecular species of cholesteryl esters catalyzed by LCAT, altering the plasma profi le of cholesteryl esters ( 106 ).…”

Section: Sphingolipidsmentioning

confidence: 99%

Unraveling the complexities of the HDL lipidome

Kontush

Lhomme

Chapman

2013

Journal of Lipid Research

314

247

View full text Add to dashboard Cite

show abstract

“…6 It has been reported that the HDL concentration of patients with hypertension does not differ from that of healthy controls, but the phospholipid compositions of HDL are altered, which may impair the functional capacity of HDL in inducing cholesterol efflux. 7 On the cellular aspects of cholesterol efflux, no studies regarding the expression of the three important transporters/receptor of ABCA1, ABCG1 and SR-BI, and their functional effects of cholesterol efflux in hypertensive conditions, have been carried out. Therefore, the aims of this study were to investigate whether the expression of ABCA1, ABCG1 and SR-BI in peripheral blood monocytes was changed in hypertensive patients, as well as its alteration on anti-hypertensive therapy, and to determine whether these alterations might affect cholesterol efflux from monocyte-derived macrophages ex vivo.…”

Section: Introductionmentioning

confidence: 99%

The expression of ATP-binding cassette transporters in hypertensive patients

Zhou

et al. 2009

Hypertens Res

View full text Add to dashboard Cite

Cholesterol efflux is regulated by cholesterol transporters, including adenosine triphosphate-binding cassette transporters, A1, G1 (ABCA1, ABCG1), and scavenger receptor class B type I (SR-BI). We have investigated whether the expression of these transporters/receptor is altered in patients with hypertension and also studied their functional effects in cholesterol efflux. The newly diagnosed hypertensive patients, as well as age-and gender-matched healthy controls were recruited. mRNA of ABCA1, ABCG1 and SR-BI in monocytes was measured. The functional effects of the three transporters/receptor and cholesterol efflux from monocyte-derived macrophages ex vivo were also determined. The expression of ABCA1 and ABCG1 was significantly decreased in the newly diagnosed untreated hypertensive patients compared with that in healthy controls. The levels of ABCA1 and ABCG1 were negatively associated with blood pressure, and the reduction of ABCA1 and ABCG1 could be reversed by antihypertensive therapy. No significant associations between plasma lipids, oxidized low-density lipoprotein (LDL) and the expression of ABCA1 or ABCG1 were found. Cholesterol efflux from monocyte-derived macrophages to autologous serum, apolipoprotein AI (apoAI) or high-density lipoprotein (HDL) was impaired in hypertensive patients. Cholesterol efflux to autologous serum or apoAI was associated with the expression of ABCA1, whereas cholesterol efflux to autologous serum or HDL was associated with the expression of ABCG1. The expression of ABCA1 and ABCG1 in monocytes is reduced in hypertensive patients, which could be reversed by anti-hypertensive therapy. The reduction in ABCA1/ABCG1 is associated with the impairment of cholesterol efflux from monocyte-derived macrophages.

show abstract

“…An increased HDL phospholipid concentration has been shown to be a valuable index in patients with multiple myeloma responding to therapy [174] or after periodontal treatment, as HDL phospholipids and the SM/PC ratio also increased in patients with periodontitis [175]. Higher HDL SM was observed in hypertensive patients [176]. …”

Section: Factors Influencing Hdl-smmentioning

confidence: 99%

Sphingomyelin in High-Density Lipoproteins: Structural Role and Biological Function

Martínez‐Beamonte

Lou-Bonafonte

Martínez-Gracia

et al. 2013

IJMS

View full text Add to dashboard Cite

High-density lipoprotein (HDL) levels are an inverse risk factor for cardiovascular diseases, and sphingomyelin (SM) is the second most abundant phospholipid component and the major sphingolipid in HDL. Considering the marked presence of SM, the present review has focused on the current knowledge about this phospholipid by addressing its variable distribution among HDL lipoparticles, how they acquire this phospholipid, and the important role that SM plays in regulating their fluidity and cholesterol efflux from different cells. In addition, plasma enzymes involved in HDL metabolism such as lecithin–cholesterol acyltransferase or phospholipid transfer protein are inhibited by HDL SM content. Likewise, HDL SM levels are influenced by dietary maneuvers (source of protein or fat), drugs (statins or diuretics) and modified in diseases such as diabetes, renal failure or Niemann–Pick disease. Furthermore, increased levels of HDL SM have been shown to be an inverse risk factor for coronary heart disease. The complexity of SM species, described using new lipidomic methodologies, and their distribution in different HDL particles under many experimental conditions are promising avenues for further research in the future.

show abstract

Parameters of high-density lipoproteins in patients with arterial hypertension in combination with other components of metabolic syndrome

Cited by 14 publications

References 12 publications

Unraveling the complexities of the HDL lipidome

Unraveling the complexities of the HDL lipidome

The expression of ATP-binding cassette transporters in hypertensive patients

Sphingomyelin in High-Density Lipoproteins: Structural Role and Biological Function

Contact Info

Product

Resources

About