Parameters of Inflammation in Morbid Obesity: Lack of Effect of Moderate Weight Loss

Solá, Eva; Jover, A; Lopez‐Ruiz, Arnaldo; Jarabo, M.; Vayá, Amparo; Morillas, Carlos; Gómez-Balaguer, Marcelino; Hernández‐Mijares, Antonio

doi:10.1007/s11695-008-9772-8

Cited by 35 publications

(30 citation statements)

References 44 publications

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“…CRP was found to be elevated in patients with morbid obesity but did not improve after moderate weight loss. 28 We found no association between BMI and hsCRP levels in our study.…”

Section: Discussioncontrasting

confidence: 71%

The influence of probiotic supplementation on gut permeability in patients with metabolic syndrome: an open label, randomized pilot study

et al. 2012

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BACKGROUND/OBJECTIVES: Obesity and metabolic disorders are linked to inflammation via gut microbiota and/or gut permeability. Gut-derived endotoxin triggers inflammation leading to metabolic syndrome (MetS) and contributing to oxidative stress. We intended to investigate the effect of Lactobacillus casei Shirota on gut permeability, presence of endotoxin and neutrophil function in MetS. SUBJECTS/METHODS: Patients with MetS were randomized to receive 3 Â 6.5 Â 10 9 CFU L. casei Shirota (probiotic group) or not for 3 months. Gut permeability was assessed by a differential sugar absorption method and by determination of diaminooxidase serum levels, endotoxin by an adapted limulus amoebocyte lysate assay, neutrophil function and toll-like receptor (TLR) expression by flow cytometry and ELISA was used to detect lipopolysaccharide-binding protein (LBP) and soluble CD14 (sCD14) levels. RESULTS: Twenty-eight patients and 10 healthy controls were included. Gut permeability was significantly increased in MetS compared with controls but did not differ between patient groups. None of the patients were positive for endotoxin. LBP and sCD14 levels were not significantly different from healthy controls. High-sensitive C-reactive protein and LBP levels slightly but significantly increased after 3 months within the probiotics group. Neutrophil function and TLR expression did not differ from healthy controls or within the patient groups. CONCLUSIONS: Gut permeability of MetS patients was increased significantly compared with healthy controls. L. casei Shirota administration in the MetS patients did not have any influence on any parameter tested possibly due to too-short study duration or underdosing of L. casei Shirota.

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“…CRP was found to be elevated in patients with morbid obesity but did not improve after moderate weight loss. 28 We found no association between BMI and hsCRP levels in our study.…”

Section: Discussioncontrasting

confidence: 71%

The influence of probiotic supplementation on gut permeability in patients with metabolic syndrome: an open label, randomized pilot study

et al. 2012

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“…Significantly higher levels of TNF-α in the blood of patients with morbid obesity recorded in the current study are consistent with the results reported by Solá et al (2009) patients with morbid obesity and by Goyal et al (2012) in patients with severe obesity (BMI>30 kg/m 2 ) and type 2 diabetes. Cardillo et al (2006) studied 26 low-fat and 27 low-carbohydrate participants with a BMI of >35 kg/m 2 and found no differences in the concentration of TNF-α after 6 and 36 months of the observation period, independent of the diet regimen.…”

Section: Discussionsupporting

confidence: 92%

“…The observed increase in CRP levels reported in patients with morbid obesity is consistent with the studies of Hofso et al (2009), van Dielen et al (2001, and Solá et al (2009). In patients with morbid obesity there was a positive correlation between the concentration of CRP and BMI before the BT, which is in line with the results reported by Visser et al (1999).…”

Section: Discussionsupporting

confidence: 90%

“…Our results are inconsistent with those reported by Cardillo et al (2006) who found no significant improvement in CRP levels of participants following either a low-carbohydrate diet or a conventional low-fat diet for 36 months. Likewise, in 67 severe or morbidly obese patients submitted to a 4-week very low-calorie diet followed by a lowcalorie diet for 2 months, Solá et al (2009) found no changes in CRP, IL-6, or TNF-α levels after weight reduction (19.6%). These divergent results might be due to the volume of weight reduction, the type of treatment (low-fat, low-carbohydrate, very lowcalorie diet, or bariatric surgery), or the duration of the observation period, which tended to differ in each study.…”

Section: Discussionmentioning

confidence: 90%

“…Xydakis et al (2004) found no differences in TNF-α concentrations among obese individuals (56 women and 24 men with a BMI of >(38.3±0.7) kg/m 2 ) after 4-6 weeks of weight loss induced by a very low calorie diet. Perhaps the metabolic stress results from a relative starvation effect on the inflammatory response (Vázquez et al, 2005;Solá et al, 2009). However, Zahorska-Markiewicz et al (2008) reported an impact of weight loss on the level of TNF-α in obese women.…”

Section: Discussionmentioning

confidence: 99%

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CRP, but not TNF-α or IL-6, decreases after weight loss in patients with morbid obesity exposed to intensive weight reduction and balneological treatment

Rość

Adamczyk

Boińska

et al. 2015

J. Zhejiang Univ. Sci. B

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Abstract:Objective: The aim of this study was to evaluate the concentrations of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and the degree of homeostasis model assessment-insulin resistance (HOMA-IR) in patients with morbid obesity exposed to a three-week low-calorie diet and balneotherapy. Methods: The study included 33 patients (25 females and 8 males; mean age 46 years) with body mass index (BMI) values of >40 kg/m 2 . Evaluations of CRP, IL-6, TNF-α, lipid profile, HOMA-IR, and fasting glucose were carried out before (baseline data) and three weeks after the treatment. The control group consisted of 20 healthy volunteers (15 females and 5 males) with a mean age of 39 years and BMI values of ≤24.9 kg/m 2 . Results: In the blood of patients with morbid obesity we found significantly elevated levels of CRP, TNF-α, triglycerides, HOMA-IR and fasting glucose, but a decreased level of high density lipoprotein (HDL)-cholesterol, compared with the healthy individuals. The treatment resulted in about a 9.4% reduction in body weight from 122.5 to 111.0 kg and a significant decrease in the concentration of CRP, but no change in TNF-α or IL-6. HOMA-IR was significantly reduced. Conclusions: The decrease in CRP level without changes in TNF-α or IL-6 concentrations after the low-calorie diet and balneological treatment, suggests that an essential amount of adipose tissue must be removed before proper adipocyte function is restored. The decrease in HOMA-IR indicates an improvement in insulin sensitivity, which is beneficial in obese patients.

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Elevated white blood cell count is associated with prevalence and development of the metabolic syndrome and its components in the general population

et al. 2012

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The metabolic syndrome (MS) is characterized by chronic inflammation. We aimed to determine the association of white blood cell (WBC) count with prevalence and development of the MS and its components in the general population. A cohort of 1,329 subjects from the local working population aged 41.3 ± 7.5 years and recruited since 2000-2008 was followed up for 4.0 ± 1.2 years. WBC count and MS components were determined at baseline and follow-up. To determine whether WBC predicted incident MS, we used a logistic regression analysis adjusted for demographics, baseline variables that define MS components, smoke, medications, and follow-up duration. Cross-sectionally in the whole population, WBC count increased in parallel with the number of MS components in the same individual, and the presence of each component was associated with higher WBC count. Baseline WBC count was significantly higher in subjects with prevalent MS. Among subjects without MS at baseline, those who developed MS had significantly higher WBC than those who did not develop MS at follow-up. Development of each MS component was associated with increased WBC count. WBC count remained significantly associated with MS development after correction for several potential confounders (OR for 1 SD increase in WBC 1.26; 95 % CI 1.01-1.58). In conclusion, elevated WBC is intimately linked to the prevalence and future development of the MS in a young population of working subjects.

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Parameters of Inflammation in Morbid Obesity: Lack of Effect of Moderate Weight Loss

Abstract: Obesity is associated to a chronic inflammatory state that seems to be due to an increased secretion of cytokines, and this state is not related to the presence of metabolic syndrome. Moderate weight loss does not ameliorate this inflammatory state in the short term.

Cited by 35 publications

References 44 publications

The influence of probiotic supplementation on gut permeability in patients with metabolic syndrome: an open label, randomized pilot study

The influence of probiotic supplementation on gut permeability in patients with metabolic syndrome: an open label, randomized pilot study

CRP, but not TNF-α or IL-6, decreases after weight loss in patients with morbid obesity exposed to intensive weight reduction and balneological treatment

Elevated white blood cell count is associated with prevalence and development of the metabolic syndrome and its components in the general population

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