Parameters of ovarian reserve in relation to urinary concentrations of parabens

Jurewicz, Joanna; Radwan, Michał; Wielgomas, Bartosz; Karwacka, Anetta; Klimowska, Anna; Kałużny, Paweł; Radwan, Paweł; Hanke, Wojciech

doi:10.1186/s12940-020-00580-3

Cited by 47 publications

(37 citation statements)

References 29 publications

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“…Therefore, the above-mentioned data confirm that the inhabitants of Poland are exposed to the adverse effects of parabens, not only contained, for example, in cosmetics, but also polluting the environment. Knowledge concerning biomonitoring of human exposure to PBs in people living in Poland are also extremely scanty and limited to only three studies 26 – 28 . These studies have described concentration levels of selected PBs in human urine.…”

Section: Discussionmentioning

confidence: 99%

“…The concentration of MePB (the PB observed in the human body in the highest concentration) fluctuates from 0.8 ng/g in human breast milk in the USA 25 to 14,187 ng/g in the hair in Spain 13 , according to the literature. However the knowledge of human exposure to PBs in Poland is extremely scanty and limited to a description of PBs present in human urine 26 – 28 .…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of human exposure to parabens in north eastern Poland through hair sample analysis

Wojtkiewicz

Tzatzarakis

Vakonaki

et al. 2021

Sci Rep

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Parabens (PBs) are a group of substances commonly used in industry. They also pollute the environment, penetrate into living organisms and adversely affect various internal organs. During this study, the degree of exposure of people living in Olsztyn, a city in north eastern Poland, to selected parabens most often used in industry was studied. The chemicals under investigation included: methyl paraben—MePB, ethyl paraben—EtPB, propyl paraben—PrPB, benzyl paraben BePB and butyl paraben -BuPB. To this aim, hair samples collected from the scalps of 30 volunteers were analyzed using a liquid chromatography–mass spectrometry technique. All PBs studied were present in a high percentage of analyzed samples (from 76.7% in the case of BePB to 100% in the case of MePB and PrPB). The mean concentration levels were 4425.3 pg/mg for MeBP, 704.0 pg/mg for EtPB, 825.7 pg/mg for PrPB, 135.2 pg/mg for BePB and 154.5 pg/mg for BuPB. Significant differences in PB concentration levels between particular persons were visible. On the other hand, gender, age and artificial hair coloring did not cause statistically significant differences in PB levels. Obtained results have clearly indicated that people living in north eastern Poland are exposed to various PBs, and therefore these substances may affect their health status. However, the evaluation of PBs influence on human health requires further research.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of human exposure to parabens in north eastern Poland through hair sample analysis

Wojtkiewicz

Tzatzarakis

Vakonaki

et al. 2021

Sci Rep

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“…Environmental Exposure Studies Using Direct Exposure Assessment/Biomonitoring Strategies Jurewicz et al in 2020 studied exposure to pyrethroid pesticides and ovarian reserve in 511 females, aged 25-39 years, attending an infertility clinic in Poland [34]. Greater urinary concentrations of 3-PBA were associated with decreased antral follicle count (p = 0.02) and levels of anti-mullerian hormone (AMH) (p = 0.03) and increased follicle-stimulating hormone (FSH) (p = 0.04).…”

Section: Ovarian Reserve and Hormone Levelsmentioning

confidence: 99%

Reproductive Health Risks Associated with Occupational and Environmental Exposure to Pesticides

Fučić

Duca

Galea

et al. 2021

IJERPH

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A marked reduction in fertility and an increase in adverse reproductive outcomes during the last few decades have been associated with occupational and environmental chemical exposures. Exposure to different types of pesticides may increase the risks of chronic diseases, such as diabetes, cancer, and neurodegenerative disease, but also of reduced fertility and birth defects. Both occupational and environmental exposures to pesticides are important, as many are endocrine disruptors, which means that even very low-dose exposure levels may have measurable biological effects. The aim of this review was to summarize the knowledge collected between 2000 and 2020, to highlight new findings, and to further interpret the mechanisms that may associate pesticides with infertility, abnormal sexual maturation, and pregnancy complications associated with occupational, environmental and transplacental exposures. A summary of current pesticide production and usage legislation is also included in order to elucidate the potential impact on exposure profile differences between countries, which may inform prevention measures. Recommendations for the medical surveillance of occupationally exposed populations, which should be facilitated by the biomonitoring of reduced fertility, is also discussed.

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“…For example, heavy smoking, long-term exposure to secondhand smoking, and indoor burning of wood or artificial fire logs have been found to be associated with decreased ovarian reserve in some studies [ 10 , 11 ]; however, these findings were not replicated in other studies [ 12 , 13 ]. Environmental exposure to endocrine disrupting chemicals such as parabens was reported to be negatively associated with ovarian reserve [ 14 ]. Recent reports corroborate that exposure to higher levels of PM is associated low ovarian reserve parameters [ 15 – 17 ].…”

Section: Introductionmentioning

confidence: 99%

Outdoor air pollution and diminished ovarian reserve among infertile Korean women

Kim

Choe

Kim

et al. 2021

Environ Health Prev Med

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Background Mounting evidence implicates an association between ambient air pollution and impaired reproductive potential of human. Our study aimed to assess the association between air pollution and ovarian reserve in young, infertile women. Methods Our study included 2276 Korean women who attended a single fertility center in 2016–2018. Women’s exposure to air pollution was assessed using concentrations of particulate matter (PM10 and PM2.5), nitrogen dioxide (NO2), carbon monoxide (CO), sulfur dioxide (SO2), and ozone (O3) that had been collected at 269 air quality monitoring sites. Exposure estimates were computed for 1, 3, 6, and 12 months prior to the ovarian reserve tests. Anti-Müllerian hormone (AMH) ratio (defined as an observed-to-expected AMH based on age) and low AMH (defined as < 0.5 ng/mL) were employed as indicators of ovarian reserve. We included a clustering effect of 177 districts in generalized estimating equations approach. A secondary analysis was conducted restricting the analyses to Seoul residents to examine the association in highly urbanized setting. Results The mean age was 36.6 ± 4.2 years and AMH level was 3.3 ± 3.1 ng/mL in the study population. Average AMH ratio was 0.8 ± 0.7 and low AMH was observed in 10.3% of women (n=235). The average concentration of six air pollutants was not different between the normal ovarian reserve and low AMH groups for all averaging periods. In multivariable models, an interquartile range (IQR)-increase in 1 month-average PM10 was associated with decrease in AMH ratio among total population (β= −0.06, 95% confidence interval: −0.11, 0.00). When we restrict our analysis to those living in Seoul, IQR-increases in 1 and 12 month-average PM2.5 were associated with 3% (95% CI: −0.07, 0.00) and 10% (95% CI: −0.18, −0.01) decrease in AMH ratio. The ORs per IQR increase in the six air pollutants were close to null in total population and Seoul residents. Conclusions In a cohort of infertile Korean women, there was a suggestive evidence of the negative association between ambient PM concentration and ovarian reserve, highlighting the potential adverse impact of air pollution on women’s fertility.

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Parameters of ovarian reserve in relation to urinary concentrations of parabens

Cited by 47 publications

References 29 publications

Evaluation of human exposure to parabens in north eastern Poland through hair sample analysis

Evaluation of human exposure to parabens in north eastern Poland through hair sample analysis

Reproductive Health Risks Associated with Occupational and Environmental Exposure to Pesticides

Outdoor air pollution and diminished ovarian reserve among infertile Korean women

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