Parameters of oxidative stress and echocardiographic indexes in patients on dialysis therapy

Abstract

Aim: Quantity of oxidative stress (OS) is enhanced in every stage of chronic renal failure (CRF). OS and its effects on echocardiographic indexes in patients on hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) were evaluated. Materials and methods: Thirty-nine patients on CAPD, 32 patients on HD, and 30 healthy individuals with similar demographic features were included. Patients with diabetes mellitus and chronic inflammatory diseases were excluded. Blood samples were collected to examine hematological and biochemical parameters and levels of malonyldialdehyde (MDA), glutathione peroxidase (GSH-px), and superoxide dismutase (SOD) after a 12-hour fasting period in the middle of dialysis week. OS parameters were compared with ejection fraction (EF), interventricular septum diameter (IVSd), left ventricular posterior wall diameter (LVPWd), and left atrium diameter (LAd) determined in M-mod echocardiographic examination. Results: No significant difference was observed between MDA and GSH-px levels of patients and control group; however, SOD levels of patients group were significantly lower (p < 0.0001). SOD levels of patients on HD were lower than that of patients on CAPD (p = 0.039). No correlation was determined between antioxidants and cardiac indexes. Conclusion: SOD levels decreased significantly especially in patients on HD, and it was observed that lower levels of SOD would lead to OS in patients on HD and CAPD when compared to healthy individuals; MDA levels were independently influenced from EF.

The Assessment of Oxidative Stress on Patients with Chronic Renal Failure at Different Stages and on Dialysis Patients Receiving Different Hypertensive Treatment

“…In a multitude of studies, it has been found that in CRF, while MDA rises [20][21][22][23], antioxidant levels fall compared to the control group [24][25][26]. Several studies have shown that while the same findings may be observed in PD patients as well, antioxidant levels are more favorable in HD group [26,27]. It has been showed that antioxidant levels of predialysis group, on the other hand, are lower than in the control group, but higher than in HD or PD group [5,27].…”

Coenzyme Q10and its Relation with Oxidant and Antioxidant System Markers in Patients with End-Stage Renal Disease

“…However, previous studies reported conflicting results regarding MDA levels in different dialysis modalities. 22,24,27,28 These variable results may be due to some confounding factors related to the method of study of MDA. 29 Another factor which should be taken into account is that MDA is found in two forms: bound and free MDA.…”

Prolidase, Matrix Metalloproteinases 1 and 13 Activity, Oxidative-Antioxidative Status as a Marker of Preterm Premature Rupture of Membranes and Chorioamnionitis in Maternal Vaginal Washing Fluids

“…Another antioxidant enzyme glutathione peroxidase (GPx) activity was determined by the coupled assay procedure of Gunzler et al 21. One unit of enzyme activity is reported as one μmol of NADPH oxidized per minute.…”