Although tsunamis in the Black Sea are rare and less destructive, recently, their study has been the subject of interest due to the increasing concentration of population and infrastructure in low-lying coastal areas. This study aims to elucidate the spatial–temporal characteristics of earthquakes in the Black Sea region (27° E–42° E and 40° N–47° N) over a century to clarify the seismicity pattern further to be used for probabilistic seismic and tsunami hazard analysis. Significant volumes of seismic data from international and national databases were analyzed, and the results obtained from previous research were supplemented and expanded. Earthquakes over the period 1905–2022 from eight up-to-date seismic catalogs were used to compile a unified catalog after conversion to the moment magnitude scale Mw. The best-fit linear relationship between several magnitude scales and Mw was determined using the general orthogonal regression (GOR) and the least squares method (LSM). After the declustering procedure, the compiled catalog consists of 18,528 unique events. To assess the catalog data quality, the magnitude of completeness Mc was estimated for the entire catalog (1905–2022) and the so-called instrumental catalog (1977–2022). In addition, the spatial distribution of the completeness magnitude Mc and the recurrence b-plot slope in the Gutenberg–Richter distribution law were assessed using the goodness-of-fit and maximum likelihood methods from the instrumental catalog data. Finally, the most significant earthquakes within the Black Sea boundaries were estimated with their parameters and focal mechanisms. A possibility of the realization of strong quakes in the near future with tsunamigenic potential in the Black Sea region was concluded.