Parameters of the meal pattern in rats: Their assessment and physiological significance

Magnen, J. Le; Devos, M.

doi:10.1016/0149-7634(80)90040-8

Cited by 112 publications

(36 citation statements)

References 36 publications

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“…In a recent experiment [7], it was shown that at night, in rats, an increment in liver glycogen occurs from meal to meal. So liver glycogen, just like fat, is stored during the night and mobilized during the day.…”

Section: Discussionmentioning

confidence: 99%

A Fall in Blood Glucose Level Precedes Meal Onset in Free‐Feeding Rats

Magnen

1996

Obesity Research

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MAGIEN. A fall in blood glucose level precedes meal onset in free feeding rats. NEUROSCI. BIOBEHAV. REV. 4 Suppl. 1, 13-15. 1980.-It has been suggested for a long time that the metabolic stimulation to eat or the hunger arousal of eating, originated from a fall in the blood glucose level induced by the periodic failure of hepatic glucose production to match the peripheral glucose uptake. However, this suggestion has not been substantiated directly by the results of periodic blood glucose evaluations performed during intermeal intervals in freefed rats. In this experiment, a technique involving a continuous blood glucose determination over several hours was used in freefeeding, undisturbed rats. it was shown that all nocturnal and diurnal meals were preceded by a 6 to 8% fall of blood level, starting 5 to 6 min prior to meal onset. The overall consequences of these findings are discussed.LOUIS-SYLVESTRE. J. AND J. LE MAGNEN. Chez les rats se nourrissant librement. une chute de glyckmie pr&Me chaque repas. NEUROSCI. BIOBEHAV. REV. Suppl. 1, 13-15, 1980 -L'hypothkse selon laquelle la stimulation B manger ou Cveil spkifique de faim a pur origine une chute de glucCmie induite par le deficit pkriodique entre production hCpatique et utilisation pCriphCrique du glucose est ancienne. Cependant, jusqu'a present, les rksultats de dkterminations Cpisodiques de la glycCmie, pratiquks au cours des intervalles interprandiaux, chez le rat se nourrissant ad libitum n'ont pas apporte de preuve directe. Une technique permettant une dktermination continue, de longue durk, de la glycCmie chez le rat se nourrissant librement a Ct6 mise au point. Son utilisation a permis de montrer que 5 B 6 minutes avant tout repas, diume ou nocturne, se produit une chute de glycCmie de 6 B 8%.Pre-prandial blood glucose decrease Blood glucose level ALL the energy used by animals is ultimately derived from the food they eat. While tissue metabolism requires continuous supplies of utilizable fuels, nutriments are ingested only during feeding episodes or meals. Thus, food intake serves to replenish various fuel reserves: ingested foods remaining in the gastrointestinal tract, liver glycogen or fat depots. It seems reasonable to assume that the internal stimulus to eat might be related to exhaustion of at least one of these reserves. The exact nature of this internal stimulus is still controversial: the importance of the role of glucopenia has long been suggested by the demonstration that different Since the essential goal of research in this field is to account for normal spontaneous eating, it seemed appropriate to investigate the evolution of metabolic parameters along with the concomitant time patterning of meals in undisturbed free-feeding animals. In a recent study, Strubbe et al. 1191 measured blood glucose (BG) and plasma immunoreactive insulin ( I N ) during meals and during meal-to-meal intervals in the rat. To determine these parameters under normal conditions they took blood samples at 20 min intervals as long as the rat did not begin to eat...

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Section: Discussionmentioning

confidence: 99%

A Fall in Blood Glucose Level Precedes Meal Onset in Free‐Feeding Rats

Magnen

1996

Obesity Research

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“…Historically, many attempts to understand the regulation of food intake have sought to understand the control of individual meals, a proposed physiologically relevant unit of intake (Le Magnen and Devos 1980;Tolkamp et al 2000). Such efforts seek to identify whether endogenous and exogenous factors influence the initiation, maintenance or termination of meals (Campfield 1997;Woods et al 2000).…”

Section: Introductionmentioning

confidence: 99%

Leptin and post-prandial satiety: acute central leptin more potently reduces meal frequency than meal size in the rat

et al. 2004

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“…7,10,19,42,58,59). Typically, a meal has been conceptualized with two-process models, whereby a cluster of feeding events (i.e., a "meal") is separated from other clusters by a nonfeeding interval (i.e., "intermeal interval") that is long compared with the intervals between feeding events within clusters (i.e., "intrameal intervals").…”

mentioning

confidence: 99%

Measuring meals: structure of prandial food and water intake of rats

Zorrilla

Inoue²,

Fekete³

et al. 2005

American Journal of Physiology-Regulatory, Integrative and Comp

129

179

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Attempts to understand ingestion have sought to understand the control of meals. The present study evaluated a meal definition that included prandial drinking (drinking-explicit meals). The spontaneous nocturnal intake of male Wistar rats was studied. The meal breakpoint was defined as the interval between feeding or drinking events providing the most stable estimate of meal structure. Alternative breakpoints derived from prevailing methodology, log-survivorship, or frequency histogram analysis of interfeeding intervals without respect to drinking were compared (drinking-naive meals). Threshold interfeeding intervals that accounted for drinking indirectly were evaluated as surrogate breakpoints (drinking-implicit meals). Definitions were compared by determining which criterion better conformed to predictions of satiety. Microstructural differences resulting from the definitions were also studied. Under the drinking-explicit definition, rats averaged nine or ten 13-min meals/night, during which they consumed food and water equally in duration (5-6 min) and quantity (2.3 g). Individual differences were observed in microstructure measures. Meals defined by drinking-informed, but not drinking-naive, methods were followed by the behavioral satiety sequence and by an initially low likelihood of resuming feeding that monotonically increased with time. The drinking-explicit definition uniquely revealed preprandial and postprandial correlations of similar magnitude. Under drinking-informed definitions, food restriction increased meal size, whereas drinking-naive definitions increased meal frequency. Drinking-implicit definitions provided workable approximations of meal frequency and size but inferior estimates of feeding duration, eating rate, and the preprandial correlation. Thus log-survivorship analysis is not appropriate for identifying meal breakpoints, and the consideration of drinking in meal definitions can provide a better estimate of meal structure. feeding or drinking; food-associated drinking; meal size or duration; eating rate; intermeal interval; behavioral satiety sequence; bout microstructure analysis; meal pattern analysis; satiation

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Parameters of the meal pattern in rats: Their assessment and physiological significance

Cited by 112 publications

References 36 publications

A Fall in Blood Glucose Level Precedes Meal Onset in Free‐Feeding Rats

A Fall in Blood Glucose Level Precedes Meal Onset in Free‐Feeding Rats

Leptin and post-prandial satiety: acute central leptin more potently reduces meal frequency than meal size in the rat

Measuring meals: structure of prandial food and water intake of rats

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