Parametrial and rectovaginal adenocarcinoma arising from endometriosis

Ulrich, U.; Rhiem, Kerstin; Kaminski, Monique; Wardelmann, Eva; Trog, Daniela; Valter, Markus M.; Richter, Otto

doi:10.1111/j.1525-1438.2005.00184.x

Cited by 48 publications

(37 citation statements)

References 14 publications

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“…Nevertheless, it was possible that the rectovaginal septum tumor was a primary serous adenocarcinoma concurrent with fallopian-tube carcinoma, because there are approximately 20 reports of primary adenocarcinomas of the rectovaginal septum, although most of them are endometrioid adenocarcinoma associated with deep endometriosis [2]. To resolve this issue, we analyzed the mutational status of TP53, as somatic mutations are commonly observed in serous adenocarcinoma of the ovaries, fallopian tube, and peritoneum [3].…”

Section: Discussionmentioning

confidence: 99%

An inconspicuous fallopian-tube carcinoma clinically manifested as a rectovaginal septal tumor: a pitfall for diagnosis and treatment

et al. 2010

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We report an unusual metastasis of an inconspicuous fallopian-tube carcinoma to the rectovaginal septum in a 67-year-old woman. The 4-cm tumor of serous adenocarcinoma was identified in the rectovaginal space with intact vaginal and rectal mucosa. The patient underwent an abdominoperineal resection with adjacent rectum and the bilateral uterine annexes, which were macroscopically intact. Unexpectedly, invasive and intraepithelial serous adenocarcinoma in fallopian-tube fimbria was microscopically observed, suggesting that the fallopian fimbria was the origin of the rectovaginal septum tumor. The clonality of these two tumors was confirmed by the presence of an identical single nucleotide point mutation in TP53. The patient received six cycles of adjuvant paclitaxel and carboplatin combination chemotherapy. There was no sign of recurrence after 17 months of treatment. This case study demonstrates that the fallopian-tube carcinoma, which exhibited minimal growth in the primary site, has the potential to metastasize to the retroperitoneal space and suggests that the fallopian-tube fimbria must be closely examined in cases of adenocarcinoma of unknown origin.

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Section: Discussionmentioning

confidence: 99%

An inconspicuous fallopian-tube carcinoma clinically manifested as a rectovaginal septal tumor: a pitfall for diagnosis and treatment

et al. 2010

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“…Ulrich U. et al [5] reported that the most frequent site in 139 cases of extra-ovarian cancer arising from endometriosis was the bowel (28%), followed by the rectovaginal septum (13%), uterus (arising from adenomyosis) (12%), peritoneum (6%) and others (such as broad ligament, parametrium, urinary bladder, and vagina) (44%). Reviews on the histology of malignant transformation in extra-ovarian endometriosis are primarily represented by endometrioid adenocarcinoma (69.1%), followed by sarcoma (25%) and clear cell carcinoma (4.5%) [6].…”

Section: Discussionmentioning

confidence: 99%

Endometrioid adenocarcinoma arising from abdominal wall endometriosis in the appendectomy scar: A case report

Hayashi¹,

Shoda²,

Kosaka³

et al. 2013

OJOG

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We report a very rare case of endometrioid adenocarcinoma arising from abdominal wall endometriosis in the appendectomy scar. A 47-year-old woman visited the surgical department, since she had a gradually growing and painful tumor both in an appendectomy scar and at an umbilical site. She underwent appendectomy at age 18 years, and noticed the tumor at age 22 years. Partial tumor resection was performed in that department, and the pathology revealed endometrioid adenocarcinoma. She was referred to our department for radical therapy. Tumors in the both sites were dissected together with some swelling lymph nodes in our department. A pathological diagnosis of the tumor in the umbilical site showed only benign endometriosis. In contrast, the tumor in the appendectomy scar showed benign endometriosis, atypical endometriosis and well differentiated endometrioid adenocarcinoma. Resected lymph nodes also contained endometrioid adenocarcinoma, and were diagnosed as metastases. It was concluded that the endometrioid adenocarcinoma in the tumor of the appendectomy scar was a malignant transformation arising from abdominal wall endometriosis from the pathological findings. Since the operation, adjuvant and maintenance chemotherapy with paclitaxel and carboplatin had been administered for 3 years. She is free of disease 3.5 years after the operation.

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“…Einige Typen des Ovarialkarzinoms und die ovarielle Endometriose teilen sich gewisse Eigenschaften, und zwar lokale Invasion, Neoangiogenese mit erhöhter VEGF ("vascular endothelial growth factor")-Expression, Lymphangiogenese, Resistenz gegenüber Apoptosemechanismen, COX2-Überexpression und genomische Instabilität [17,37,42,43,45]. Von den endometrioseassoziierten Malignomen sind 80 % Ovarialkarzinome, etwa 20 % betreffen extragonadale Manifestationen [10,15,19].…”

Section: Histologie Und Pathogeneseunclassified

“…Therapie der Wahl endometrioseassoziierter Malignome -sowohl EAOC als auch der extragonadalen EAM -besteht in der Resektion im Gesunden; die EAOC werden dabei dem leitliniengerechten operativen Staging unterzogen [42,46]. Die komplette chirurgische Entfernung ist fast immer gut durchführ-bar, da extrapelvine Manifestationenim Gegensatz zu den high-grade serösen Ovarialkarzinomen, die ja in der Mehrzahl im Stadium FIGO III diagnostiziert werden -bei diesen Tumoren selten sind.…”

Section: Bisherige Klinische Bedeutungunclassified

“…Endometriosis · Malignant tumors · Mutation · Endometrioma · Ovarian cancer vor allem für die extragonadalen EAM der Rektumwand, des Septum rectovaginale, der Parametrien oder Paraproktien gelten, wenn es sich -wie meistens -um ein rein pelvines Geschehen handelt [11,14,42]. Da diese Fälle Raritäten sind, gibt es keine allgemeingültigen Empfehlungen.…”

Section: Introductionunclassified

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Malignome auf dem Boden einer Endometriose

Ulrich

Drienko

Reichert

et al. 2016

Gynäkologische Endokrinologie

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Zwischen 5 und 15 % aller Frauen in der Prämenopause sind von Endometriose betroffen [33] -und für Frauen mit Sterilität stellt diese Erkrankung ein besonderes Problem dar [12]. Operative Entfernung, endokrine Behandlung und bei unerfülltem Kinderwunsch die assistierte Reproduktion sind die Säulen der Therapie [41]. Pathologisch-histologisch ist die Endometriose prinzipiell eine benigne Erkrankung. Malignes Wachstum und Endometriose weisen jedoch einige gemeinsame Charakteristika auf, und auf dem Boden einer Endometriose können sich Malignome entwickeln [37]. Mit diesem Phänomen beschäftigen sich die Autoren in der folgenden Übersicht.

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Parametrial and rectovaginal adenocarcinoma arising from endometriosis

Cited by 48 publications

References 14 publications

An inconspicuous fallopian-tube carcinoma clinically manifested as a rectovaginal septal tumor: a pitfall for diagnosis and treatment

An inconspicuous fallopian-tube carcinoma clinically manifested as a rectovaginal septal tumor: a pitfall for diagnosis and treatment

Endometrioid adenocarcinoma arising from abdominal wall endometriosis in the appendectomy scar: A case report

Malignome auf dem Boden einer Endometriose

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