Parametric Analysis of an Integrated Model of Cardio-respiratory Interactions in Adults in the Context of Obstructive Sleep Apnea

Guerrero, Gustavo; Rolle, Virginie Le; Hernández, Alfredo

doi:10.1007/s10439-021-02828-6

Cited by 5 publications

(5 citation statements)

References 36 publications

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“…Hence, a necessary condition for the Q-R relation to hold must be R ≫ LK at all outlets; otherwise, LK would appear in Eq. (4).…”

Section: Choice Of Resistancementioning

confidence: 99%

“…Our findings also establish constraints on the parameters controlling the numerical stability of the simulations. The findings from this work are directly applicable to larger and more complex vascular domains encountered at full-human scale.In recent years, the central goal of computational biomedicine to create a virtual human, also referred to as a human digital twin, has become increasingly tangible [1][2][3][4] . A virtual human is a detailed, digital representation of an individual's biophysical processes 5,6 .…”

mentioning

confidence: 99%

“…In recent years, the central goal of computational biomedicine to create a virtual human, also referred to as a human digital twin, has become increasingly tangible [1][2][3][4] . A virtual human is a detailed, digital representation of an individual's biophysical processes 5,6 .…”

mentioning

confidence: 99%

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Parametric analysis of an efficient boundary condition to control outlet flow rates in large arterial networks

McCullough

Coveney

2022

Sci Rep

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Substantial effort is being invested in the creation of a virtual human—a model which will improve our understanding of human physiology and diseases and assist clinicians in the design of personalised medical treatments. A central challenge of achieving blood flow simulations at full-human scale is the development of an efficient and accurate approach to imposing boundary conditions on many outlets. A previous study proposed an efficient method for implementing the two-element Windkessel model to control the flow rate ratios at outlets. Here we clarify the general role of the resistance and capacitance in this approach and conduct a parametric sweep to examine how to choose their values for complex geometries. We show that the error of the flow rate ratios decreases exponentially as the resistance increases. The errors fall below 4% in a simple five-outlets model and 7% in a human artery model comprising ten outlets. Moreover, the flow rate ratios converge faster and suffer from weaker fluctuations as the capacitance decreases. Our findings also establish constraints on the parameters controlling the numerical stability of the simulations. The findings from this work are directly applicable to larger and more complex vascular domains encountered at full-human scale.

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“…Hence, a necessary condition for the Q-R relation to hold must be R ≫ LK at all outlets; otherwise, LK would appear in Eq. (4).…”

Section: Choice Of Resistancementioning

confidence: 99%

mentioning

confidence: 99%

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Parametric analysis of an efficient boundary condition to control outlet flow rates in large arterial networks

McCullough

Coveney

2022

Sci Rep

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“…We have recently proposed an integrated cardio-respiratory model adapted to the physiology of preterm neonates [9]. This model is an adaptation of an adult model previously proposed by our team [10][11][12]. Structural modifications were made as well as parameter adjustments based on the preterm infants literature [6,13], by scaling method [7] and manual adaptations.…”

Section: Introductionmentioning

confidence: 99%

Model-Based Analysis of Apnea-Bradycardias in Newborns

Duport¹,

Rolle²,

Guerrero³

et al. 2022

Computing in Cardiology Conference (CinC)

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In preterm infants, recurrent episodes of apnea, bradycardia and severe intermittent hypoxia are mainly related to cardiorespiratory immaturity. These episodes are associated with major risks during the first weeks of life. Cardiorespiratory data consisting of a continuous 12 hours recording of transthoracic impedance and ECG signals were acquired in 18 preterm neonates. 106 isolated apnea events (>10 sec) were manually annotated from the database, of which 19 apneas with bradycardia. A systemlevel physiological model of cardio-respiratory interactions in the newborn is proposed and used to reproduce simulations of mixed apneas with and without bradycardia, by modifying the functional residual capacity. A first qualitative comparison between the simulations and the clinical data shows a close match between the experimental and simulated heart rate series during apnea with bradycardia (RMSE 4.96 bpm) and without (RMSE 2.02 bpm).

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“…To this end, an essential step is the development of mathematical models that describe relevant physiological and/or pathological processes. For example, in this issue Guerrero et al 6 proposed a model of cardio-respiratory interactions for obstructive sleep apnea. In line with the increased attention in recent years on the microvasculature, Spieker et al 14 investigated fundamental mechanisms of platelet adhesion at the single vessel scale.…”

mentioning

confidence: 99%

Special Issue of the VPH2020 Conference: “Virtual Physiological Human: When Models, Methods and Experiments Meet the Clinic”

et al. 2022

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Parametric Analysis of an Integrated Model of Cardio-respiratory Interactions in Adults in the Context of Obstructive Sleep Apnea

Cited by 5 publications

References 36 publications

Parametric analysis of an efficient boundary condition to control outlet flow rates in large arterial networks

Parametric analysis of an efficient boundary condition to control outlet flow rates in large arterial networks

Model-Based Analysis of Apnea-Bradycardias in Newborns

Special Issue of the VPH2020 Conference: “Virtual Physiological Human: When Models, Methods and Experiments Meet the Clinic”

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