Parametric and Nonparametric Methods in Medical Statistics

Герасимов, А. Н.; Морозова, Н. И.

doi:10.31631/2073-3046-2015-14-5-6-12

Cited by 11 publications

(4 citation statements)

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“…To check the applicability of parametric statistics methods, we calculated the values of skewness ration and kurtosis. The value for all numerical indicators that we used turned out to be quite small, which made it possible to use the contrast of means using analysis of variance [16].…”

Section: Discussionmentioning

confidence: 99%

Dynamics of quality of life indicators associated with weight loss in patients with metabolically healthy obesity

Ostrovskaya¹,

Романцова²,

Gerasimov³

et al. 2019

Russ Open Med J

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The purpose of the study was to analyse quality of life (QoL) indicators in patients with metabolically healthy obesity (MHO) associated with ≥ 5% weight loss. Material and Methods -The study involved 44 females with MHO (according to the IDF criteria of the metabolic syndrome (MS), 2005) and 33 females with metabolically unhealthy obesity (MUHO) aged 19-59 years. To assess QoL, we used the SF-36 questionnaire (Medical Outcomes Study -Short Form 36). Results -Initially QoL indicators in both groups were not significantly different statistically. The physical component of health (PHsum) in the MHO and MUHO groups averaged 53.9±6.7 & 50.6±6.3 points (p=0.032). The mental component of health (MHsum) averaged 42.1±1.8 & 45.1±1.8 points (p=0.255). The ≥5% decrease in body weight (from the initial body weight) after 6 months led to an increase in the indicators of physical role functioning by 11.6%, vitality by 12.8%, social functioning by 11.2%, emotional role functioning by 11.9%, mental health by 8.8% (p<0.05) in the MHO group, while in the MUHO group the indicators of physical role functioning increased by 24.6%, emotional role functioning by 39.5%, and mental health by 9.2 % (p<0.05). Conclusion -The MHO group is characterized by higher physical component of health, without a statistically significant difference in the indicators of each of the 8 scales of the SF-36 questionnaire. A ≥ 5% decrease in the body mass in patients of both groups is accompanied by the increase in the indicators of QoL. Keywords: metabolically healthy obesity, quality of life, SF-36 questionnaire. Cite as Ostrovskaya Е.V., Romantsova Т.I., Gerasimov A.N., Novoselova Т.Е. Dynamics of quality of life indicators associated with weight loss in patients with metabolically healthy obesity. Russian Open Medical Journal 2019; 8: e0309.Correspondence to Elena V. Ostrovskaya.

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Section: Discussionmentioning

confidence: 99%

Dynamics of quality of life indicators associated with weight loss in patients with metabolically healthy obesity

Ostrovskaya¹,

Романцова²,

Gerasimov³

et al. 2019

Russ Open Med J

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“…The significance of the difference in frequencies between the compared groups was determined using the chi-square test (for the two groups, Fisher's exact solution). Sufficiently large size of compared groups and small values of asymmetry coefficients of kurtosis allowed using methods of parametric statistics [12]. For numerical data and data in scores, their characteristic values are presented as mean and standard deviation (±) and median with 25 th and 75 th percentiles.…”

Section: Methodsmentioning

confidence: 99%

Changes in local immune status in tonsillopharyngitis under pathogenic therapy with the BNO 1030 extract: a randomized, comparative, parallel-group, single-center study

Савлевич

Козлов

Gaponov

et al. 2023

Preprint

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Aim of studyThe present study aimed to evaluate anti-inflammatory and immunomodulating properties of BNO 1030 (Tonsilgon® N) and its direct effect on the indicators of the local immunity of oropharyngeal mucosa in patients with acute tonsillopharyngitis (TP) or exacerbation of chronic TP without evident systemic inflammatory syndrome.Materials and methodsA total of 60 adult patients with acute TP or exacerbation of chronic TP without severe systemic inflammatory syndrome were randomly divided into 2 groups: Group 1 L 30 patients took BNO 1030 (Tonsilgon® N), Group 2 L 30 patients took sage tablets according to the summary of product characteristics during 7 days. During 3 visits (day 1, day 3, day 7) symptoms and oropharyngeal mucosa condition were evaluated using a 10-point visual analogue scale (VAS). Local immunity parameters of oropharyngeal mucosa (cytokines: IL-1β, IL-6, IL-8, IL-10, IL-17, TNF-α, and lysozyme, lactoferrin, sIgA) were determined by ELISA and by real time polymerase chain reaction.ResultsReduction of the main symptoms was significantly faster under BNO 1030 therapy than under sage therapy. In BNO 1030 group reduction of clinical symptoms correlated with the onset of action and the local immunological parameters. During BNO 1030 treatment IL-1β, IL-6, and IL-8 mRNA levels decreased below the levels in healthy controls, while, the immune factors lysozyme, lactoferrin and sIgA increased. Therapy with sage tablets did not affect local immunity parameters.ConclusionBoth treatment regimens resulted in elimination of clinical signs and mucosal pharyngeal barrier regeneration. In contrast to the sage tablets, BNO 1030 can also affect local mucosal immunity via regulating the balance of pro- and anti-inflammatory factors.Study highlightsThis study can answer the question regarding influence on main local immunity parameters of subjects with tonsillitisThe one of main task of this study is to evaluate what local immune parameters of oral cavity are most changeableTonsilgon N usage is not decrease main local immunity parameters such as IL-1β, IL-8, lysozyme and lactoferrinThis study evaluated the functional condition of mucosal immunity of oral cavity in subjects with tonsillopharingitis

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“…The correctness of using the methods of parametric statistics was checked by analyzing the values of correlation, skewness, and kurtosis [2] using SPPS Statistics 22 software (IBM). The differences were significant at p<0.05.…”

Section: Methodsmentioning

confidence: 99%

The Role of Oral Organs in Local Immunity with Elements of Morphology of Lingual Glands

et al. 2021

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In postnatal ontogeny, the topographic relationships of the tongue glands and lymphoid structures in the thickness of the tongue have clear age-related features. In this article, we discuss the features of the glandular-lymphoid relationship in the thickness of the tongue, which is of particular scientific and practical importance for more precise understanding of the mechanisms providing local immunity in the oral cavity.

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Parametric and Nonparametric Methods in Medical Statistics

Cited by 11 publications

References 0 publications

Dynamics of quality of life indicators associated with weight loss in patients with metabolically healthy obesity

Dynamics of quality of life indicators associated with weight loss in patients with metabolically healthy obesity

Changes in local immune status in tonsillopharyngitis under pathogenic therapy with the BNO 1030 extract: a randomized, comparative, parallel-group, single-center study

The Role of Oral Organs in Local Immunity with Elements of Morphology of Lingual Glands

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