Wearable textile-based stretch sensors, for health-care monitoring, provide physiological and medical evaluation without inhibition in the daily routine life of the patient. In our previous work, we successfully coated viscose and polyester (PES) fibers with conjugated polymer, poly(3,4-ethylenedioxythiophene) (PEDOT) using chemical vapor deposition (CVD) process. In this paper, we have reported the possibility to produce large quantity of PEDOT-coated conductive fibers, which have acceptable mechanical strength and frictional properties so that the knitted stretch-sensors could be produced. By utilizing these knitted structures, we have showed the possibility to produce textile-based monitoring device, which has better integration properties in wearable clothing than metal containing structures. The performance of viscose and polyester knitted structures as stretch sensors was investigated on our own designed cyclic tester. For the imitation of respiratory and joint movement, the variation in electrical properties of knitted structures was examined at 5 to 50% elongations and then the performance of viscose and PES knitted structures was compared on the basis of cyclic testing results. In order to find out the washing effects on PEDOT coatings and the knitted structures, two washing cycles were performed. After washing, the persistence of PEDOT coating on knitted structures was investigated with FT-IR spectroscopy and thermogravimetric analysis. For PES fiber, it was revealed that stretch sensing behavior was still persisted even after the washing cycles. Thus, these structures have the potential to be utilized in medical textiles for monitoring the physiological activities of patients, such as breathing rate and joint movement.