This research focuses on enhancing natural ventilation in multifamily residential buildings to improve air quality and minimize reliance on mechanical ventilation, thereby reducing energy consumption. The study pioneers the integration of passive pipe systems within structural floor slabs and building envelopes, aiming to overcome the inherent challenges of indoor environmental quality (IEQ) related to design constraints, occupant behavior, and urban context. Our innovative approach, utilizing a novel application of Grasshopper for precise architectural modeling and Ansys for advanced multiphysics simulation, enables a detailed comparative analysis of airflow dynamics across various system configurations. A comprehensive literature review underscores the significance of natural ventilation as a key passive cooling strategy, vital for reducing energy use and enhancing IEQ in the face of urbanization challenges. Our empirical findings reveal that configurations with more inlet and outlet pipes significantly outperform simpler ones, with a notable configuration of 11 pipes (5 × 6) achieving an actual-to-required ventilation rate increase in 158.15%. This evidence highlights the substantial benefits of adopting complex system configurations for improved ventilation efficiency. The study’s outcomes include impactful design recommendations for adopting enhanced natural ventilation strategies in multifamily residential buildings. These recommendations promise to inform sustainable urban planning and building management strategies, offering a scalable solution for cities seeking to balance growth with environmental sustainability. By demonstrating the clear advantages of targeted passive cooling interventions, this research contributes valuable insights toward achieving energy efficiency and superior IEQ in residential buildings, paving the way for future exploration in diverse climatic and urban contexts.