Parametric Functional Maps of Visual Inputs to the Tectum

Nikolaou, Nikolas; Lowe, Andrew; Walker, Abigail; Abbas, Fatima; Hunter, Paul R.; Thompson, Ian; Meyer, Martin

doi:10.1016/j.neuron.2013.02.020

Cited by 28 publications

(47 citation statements)

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“…Each pixel corresponds to an area of 0.3 to 0.6 mm 2 , which is in the range of single presynaptic boutons of RGC axons [30]. We compared the pixel responses to dark versus bright looming by subtracting each pixel's bright looming response from its dark looming response.…”

Section: Pixelwise Analysis Reveals a Generalized Off Response Of Rgcmentioning

confidence: 99%

A Visual Pathway for Looming-Evoked Escape in Larval Zebrafish

et al. 2015

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Avoiding the strike of an approaching predator requires rapid visual detection of a looming object, followed by a directed escape maneuver. While looming-sensitive neurons have been discovered in various animal species, the relative importance of stimulus features that are extracted by the visual system is still unclear. Furthermore, the neural mechanisms that compute object approach are largely unknown. We found that a virtual looming stimulus, i.e., a dark expanding disk on a bright background, reliably evoked rapid escape movements. Related stimuli, such as dimming, receding, or bright looming objects, were substantially less effective, and angular size was a critical determinant of escape initiation. Two-photon calcium imaging in retinal ganglion cell (RGC) axons revealed three retinorecipient areas that responded robustly to looming stimuli. One of these areas, the optic tectum, is innervated by a subset of RGC axons that respond selectively to looming stimuli. Laser-induced lesions of the tectal neuropil impaired the behavior. Our findings demonstrate a visually mediated escape behavior in zebrafish larvae exposed to objects approaching on a collision course. This response is sensitive to spatiotemporal parameters of the looming stimulus. Our data indicate that a subset of RGC axons within the tectum responds selectively to features of looming stimuli and that this input is necessary for visually evoked escape.

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Section: Pixelwise Analysis Reveals a Generalized Off Response Of Rgcmentioning

confidence: 99%

A Visual Pathway for Looming-Evoked Escape in Larval Zebrafish

et al. 2015

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“…Moreover, the results of our recent experiments performed in carp and roach indicated that DS GCs of these¯shes also coincide with retinal DS units of C. gibelio (Maximova, personal communications). Results con¯rming our¯ndings have been published by Nikolaou et al (2012). Using calcium imaging techniques they recorded visually evoked activity of the retinal GC axons innervating tectum of zebra¯sh.…”

Section: Direction-selective Circuitry In The¯sh Retinamentioning

confidence: 99%

Opposing motion inhibits responses of direction-selective ganglion cells in the fish retina

Damjanović

Maximova²,

Aliper³

et al. 2015

J. Integr. Neurosci.

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Inhibitory influences in receptive fields (RFs) of the fish retinal direction-selective ganglion cells (DS GCs) were investigated. Responses of the fast retinal DS GCs were recorded extracellularly from their axon terminals in the superficial layer of tectum opticum of immobilized fish. The data were collected from two cyprinid species - Carassius gibelio, a wild form of the goldfish, and the barbel fish Labeobarbus intermedius. Visual stimuli were presented to the fish on the monitor screen within a square area of stimulation occupying approximately 11 × 11° of the visual field. DS GCs were stimulated by pairs of narrow stripes moving in opposing directions. One of them entered central (responsive) area of cell receptive field (RRF) from the preferred, and the other one from the null side. Stimuli merged at center of stimulation area, and subsequently moved away from each other. It was shown that the cell response evoked by the stripe coming from the preferred side of RF was inhibited by the stimulus coming from the opposite direction. In the majority of units recorded inhibitory effect induced by the null-side stimulus was initiated in the RF periphery. As a rule, inhibitory influences sent from the RF periphery were spread across the entire central area of RF. Modifications of the inhibitory influences were investigated throughout the whole motion of paired stimuli. Evident inhibitory effects mediated from the null direction were recorded during the approach of stimuli. When stripes crossed each other and moved apart inhibition was terminated, and cell response appeared again. Null-side inhibition observed in fish DS GCs is most likely induced by starburst-like amacrine cells described in morphological studies of different fish species. Possible mechanisms underlying direction selectivity in fish DS GCs are discussed.

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“…3) Precise spatial information is retained, both in the arrangement of neuronal cell bodies, and fine structural organization in neuropil (Ohki et al, 2005;Komiyama et al, 2010;Nikolaou et al, 2012). 4) Subcellular signaling can be resolved, allowing the measurement of both spatial aspects of dendritic processing (Borst and Egelhaaf, 1992;Svoboda et al, 1997;Euler et al, 2002;Hill et al, 2013) and the topography of synaptic inputs (Baden and Hedwig, 2007;Bollmann and Engert, 2009;Peron et al, 2009;Hopp et al, 2014).…”

Section: Identifying the Circuits Underlying Behaviorsmentioning

confidence: 99%

“…Functional studies revealed that RGCs sensitive to different directions of whole-field motion target different tectal sublaminae (Gabriel et al, 2012;Nikolaou et al, 2012), and that neurons in the tectum integrate these inputs to generate distinct tuning characteristics (Hunter et al, 2013).…”

Section: Selected Zebrafish Contributions To Systems and Circuits Neumentioning

confidence: 99%