2012
DOI: 10.1364/boe.3.000366
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Parametric imaging of the local attenuation coefficient in human axillary lymph nodes assessed using optical coherence tomography

Abstract: We report the use of optical coherence tomography (OCT) to determine spatially localized optical attenuation coefficients of human axillary lymph nodes and their use to generate parametric images of lymphoid tissue. 3D-OCT images were obtained from excised lymph nodes and optical attenuation coefficients were extracted assuming a single scattering model of OCT. We present the measured attenuation coefficients for several tissue regions in benign and reactive lymph nodes, as identified by histopathology. We sho… Show more

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Cited by 72 publications
(87 citation statements)
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“…Using the approach described in Refs [22,23], the correction for the confocal function and sensitivity fall-off with depth is performed by dividing the tissue A-scan by the phantom A-scan, leading to the corrected OCT signal as:…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Using the approach described in Refs [22,23], the correction for the confocal function and sensitivity fall-off with depth is performed by dividing the tissue A-scan by the phantom A-scan, leading to the corrected OCT signal as:…”
Section: Methodsmentioning
confidence: 99%
“…To correct for variations in OCT SNR with axial depth, we have utilized a single-scattering model of the near-infrared light [14,22,23] with the A-scan expressed as:…”
Section: Correction Of Lymphatic Vessel Threshold Values Versus Depthmentioning
confidence: 99%
“…In addition, parametric imaging techniques provide an alternate approach to quantification of the underlying structure of the tissue. Such techniques have been demonstrated to quantify the attenuation coefficient of tissue [44,45], or automatically quantify the degree of birefringence [46]. These approaches rely on segmentation of tissue types, as both the attenuation coefficient and birefringence will vary between different tissues.…”
Section: Discussionmentioning
confidence: 99%
“…16 Five main studies for in vivo transcapsular imaging as well as ex vivo analysis of lymph node with OCT have been published. [17][18][19][20][21] They were carried out with commercial and laboratory setups demonstrating axial resolution ranging from 2 to 12 mm and transverse resolution ranging from 10 to 15 mm. A few samples were imaged (18 samples maximum).…”
Section: Introductionmentioning
confidence: 99%