Parametric Modeling of Narrowband UV-B Phototherapy for Vitiligo Using a Novel Quantitative Tool

Hamzavi, Iltefat; Jain, Hem C.; McLean, David I.; Shapiro, Jerry; Zeng, Haishan; Lui, Harvey

doi:10.1001/archderm.140.6.677

Cited by 379 publications

(368 citation statements)

References 22 publications

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“…This study found that MKTP was an effective and well-tolerated procedure based on the objective scoring system for the assessment of repigmentation (Vitiligo Area Scoring Index). 40 Postoperatively, the treated area appears bright red, which lasts up to 2-3 weeks in dark-skinned patients and up to 6-12 weeks in light-skinned people. Repigmentation is observed as early as 3-4 weeks post-transplantation, with progression up to 6 months in skin types IV and V. In contrast, repigmentation begins about 8-12 weeks post-transplantation with progression up to 1 year in skin types II and III.…”

Section: Cultured and Noncultured Cellular Transplantation Methodsmentioning

confidence: 99%

Surgical interventions for vitiligo: an evidence-based review

Mulekar¹,

Isedeh

2013

Br J Dermatol

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SummaryBackground Vitiligo is a disfiguring disease, characterized frequently by the presence of de-pigmented macules and/or patches. Traditional therapies are essentially medical and are most preferred by dermatologists. Surgical therapies, however, are amongst the most effective interventions for vitiligo but are limited by their invasive nature, as well as the training and expertise needed to perform specific procedures. Objectives To assess the evidence for the effectiveness, safety and applicability of the various surgical methods in the treatment of vitiligo. Methods For this systematic review of vitiligo surgical therapies, our searches included: PubMed, MEDLINE and Cochrane databases. Results We reviewed research studies reporting on split thickness skin grafts (STSG), punch/mini-graft, blister roof grafting, cultured and non-cultured cellular transplantation (MKTP). While all methods vary in their repigmentation outcomes, STSG is found to have the highest repigmentation success rate. Overall, post-operative complications included milia, scarring, cobblestone appearance or hyperpigmentation of treated areas. Conclusion This review highlights the need for more randomized controlled trials in this field, underpinned by a more standardized objective approach to the assessment of repigmentation following surgical interventions.

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Section: Cultured and Noncultured Cellular Transplantation Methodsmentioning

confidence: 99%

Surgical interventions for vitiligo: an evidence-based review

Mulekar¹,

Isedeh

2013

Br J Dermatol

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“…History of spontaneously repigmenting vitiligo was excluded from the study. There is currently no quantitative tool for evaluating vitiligo treatment response using parametric methods (Hamzavi et al 2004). Repigmentation may starts on the hair follicle(typical perifollicular) or starts as homogenous pigmentation from the periphery of the lesions (perilesional) (Baltas & Csoma 2002).…”

Section: Methodsmentioning

confidence: 99%

Efficacy and Safety of Topical Tacrolimus (0.03%) in the Treatment Localized Vitiligo

Husain¹,

Alam²,

Rahim

et al. 2017

Med. Today

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“…The Vitiligo Area Scoring Index (VASI) was used to evaluate treatment outcome 6 . The VASI is a quantitative method used to standardize treatment outcomes.…”

Section: Assessmentmentioning

confidence: 99%

The efficacy of microphototherapy in vitiligo patients with localized lesions

Yıldırım¹,

Erkin²

2017

TURKDERM

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©Copyright 2017 by Turkish Society of Dermatology and Venereology Turkderm-Turkish Archives of Dermatology and Venereology published by Galenos Yayınevi. ÖzBackground and Design: Vitiligo is a chronic skin disease. To reduce side effects associated with current treatment modalities, new treatment methods are required. Microphototherapy was introduced to treat vitiligo patients with a limited number of lesions (lesions affecting <10% of the body surface area). Materials and Methods: Our study has aimed to evaluate the efficacy of microphototherapy in vitiligo patients with localized lesions. In this unblinded and prospective study, patients were treated thrice weekly for at least 50 sessions using an MedLight CupCUBE Grimed ® microphototherapy device which emits ultraviolet B spectrum with a starting dose of 150 mJ/cm 2 for 5 seconds and with increments of 30 mj/cm 2 , 1 second at each session. At the end of the 50 th session, 50% reduction in Vitiligo Area Scoring Index (VASI) score was accepted as the required minimum response. Results: Thirty-three lesions from 14 patients were treated. Treatment outcome was evaluated based on the VASI. Between 0 th and 50 th sessions, the mean VASI score in 33 lesions decreased from 2.25 to 1.79 showing 20.4% decline (p<0.05). Twenty-one of 33 lesions exhibited decrease in VASI scores at the end of the 50 th session although only 11 of these 21 lesions reached the target of VASI 50% while the remaining 10 lesions did not reach the target. As a result, 11 lesions (33.3%) reached VASI 50% while the remaining 22 lesions (66.7%) did not reach the target. Conclusion: The efficacy of the MedLight CupCUBE Grimed ® microphototherapy device was poor with these starting doses, durations and increments for the treatment of patients with vitiligo who had localized lesions. Trying topical therapies initially, calculating minimal erythema dose and, thus, measuring the beginning ultraviolet doses and durations as a way to decrease the number of in-hospital sessions are feasible rather than applying this technique as the first option or alone in vitiligo patients with non-segmental and localized lesions. Keywords: Vitiligo, phototherapy, treatment Amaç: Vitiligo kronik bir deri hastalığıdır. Mevcut tedavi yöntemlerine bağlı oluşabilen yan etkileri azaltmak için yeni tedavi yöntemlerine ihtiyaç bulunmaktadır. Mikrofototerapi yöntemi sınırlı sayıda lezyona sahip (lezyonların vücut yüzey alanının %10'undan azını etkilemesi) vitiligo hastalarını tedavi etmek için kullanılmaya başlamıştır. Gereç ve Yöntem: Çalışmamız lokalize lezyonlara sahip vitiligo hastalarında mikrofototerapinin etkinliğini değerlendirmeyi hedeflemektedir. Prospektif olan ve kör olmayan bu çalışmada hastalara ultraviyole (UV) B ışını yayan MedLight CupCUBE Grimed ® mikrofototerapi cihazı ile başlangıç UV dozu 150 mJ/cm 2 ve 5 saniye, her seansta doz artımı 30 mj/cm 2 ve 1 saniye olacak şekilde haftada 3 kez en az 50 seans boyunca tedavi uygulanmıştır. Vitiligo Alan Skorlama İndeksi (VASİ) %50 (VASİ'de %50 azalma) 50 ...

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Parametric Modeling of Narrowband UV-B Phototherapy for Vitiligo Using a Novel Quantitative Tool

Cited by 379 publications

References 22 publications

Surgical interventions for vitiligo: an evidence-based review

Surgical interventions for vitiligo: an evidence-based review

Efficacy and Safety of Topical Tacrolimus (0.03%) in the Treatment Localized Vitiligo

The efficacy of microphototherapy in vitiligo patients with localized lesions

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