The article analyzes the influence of historical transport routes, Kyrgyz statehood and culture, the Kyrgyz economy of that period and the Kyrgyz way of communication, as well as changes in the Kyrgyz language and the role of the Kyrgyz in intercultural communication in different historical periods. Great has influenced the statehood, culture, religion and mentality of Kyrgyz people, and surely changed the economic situation of the nomadic tribes in the times of the Great Silk Road. Great Silk Road became a huge chance to see the other people: to communicate and develop communicative skills with other cultures living on this road. The influence on to the language brought a lot of new words and terms which settled in the Kyrgyz language. Moreover, the Great Silk road gave a possibility for enlarging diplomatic relationship with the other empires and kingdoms of that period. Kyrgyz people with their nomadic style of living before communicated with a lot of people, and their language was adaptable to new languages, and it became a reason why did the most of the Kyrgyz people became the guides of caravans and even translators on the Great Silk Road.