This study presents the Taguchi design method with L9 orthogonal array which was carried out to optimize the flux-cored arc welding (FCAW) process parameters such as welding current, welding voltage, welding speed, and torch angle with reference to vertical for the ferrite content of duplex stainless steel (DSS, UNS S32205) welds. The analysis of variance (ANOVA) was applied, and a mathematical model was developed to predict the effect of process parameters on the responses. The results indicate that welding current, welding voltage, welding speed, torch angle with reference to vertical, and the interaction of welding voltage and welding speed are the significant model terms connected with the ferrite content. The ferrite content increases with the increase of welding speed and torch angle with reference to vertical, but decreases with the increase of welding current and welding voltage. Through the developed mathematical model, the target of 50% ferrite content in weld metal can be obtained when all the welding parameters are set at the optimum values. Finally, in order to validate experimental results, confirmation tests were implemented at optimum working conditions. Under these conditions, there was good accordance between the predicted and the experimental results for the ferrite content.