In recent years, the automotive industry has been developing applied research to meet customer’s needs; considering safety, vehicle comfort and energetic efficiency. In particular, automotive tires have a prominent position in this research area, ensuring good vehicle handling, comfort and safety. In the vehicle dynamics performance, excellent gripping and reduced rolling resistance in the tires are crucial to maximize the energetic efficiency in a reliable way. However, to ensure such a level of reliability in vehicle operation, the inherent uncertainties of tires, as well as other factors subject to variability must be taken into account in the vehicle design. In this way, the present paper analyzes in detail the effect of variations in some parameters such as ambient temperature, ground conditions, vertical load, speed and tire inflation on the analysis of vehicle dynamics. A Metamodeling approach associated with the Monte Carlo Simulation was employed to develop the mathematical models to analyze the effect of uncertain parameters on the tire rolling resistance; traction, centripetal and lateral forces, using experimental data from the literature, in the longitudinal and lateral vehicle dynamics. Therefore, the present research brings as an innovation an integrated approach to the input parameters of the system with the rolling resistance through the developed metamodels. There was a substantial variability of up to 15% both up and down in the Maximum Traction Force of a vehicle in response to variations in the vehicle’s weight and the coefficient of tire rolling resistance. In contrast, the Lateral Force exhibited a greater variability, with a 25 downward and 10% upward variation associated with the weight and friction coefficient variability of the vehicle. Further investigations into the sensitivity analysis highlight the significant influence of the friction coefficient and temperature on the Traction Forces of the vehicle.