The problem of aircraft entering and exiting water is a complex, nonlinear, strongly disturbed, and multi-coupled multiphase flow problem, which involves the precise capture of the air/water interface and the multi-coupling interaction between aircraft, water, and air. Moreover, due to the large difference in medium properties during the crossing, the load on the body will suddenly change. In this paper, the VOF (volume of fluid) algorithm is used to capture the liquid surface at the air/water interface, and since body movement is involved in this process, the overset grid technology is used to avoid the traditional dynamic grid deformation problem. In the process of this numerical simulation prediction, the effects of different water-entry angles and different water-entry heights on the body load and attitude of the trans-medium aircraft, as well as the cavitation evolution law of the body water entry are analyzed. On this basis, to simulate the authenticity and complexity of the water-entry environment, numerical wave-making technology was introduced to analyze the water-entry load, posture, and cavitation evolution law of the body under different wave environments. The numerical parameters under the condition of wave and no wave are compared, and the difference in water-entry performance under the condition of wave and no wave is analyzed.