Parámetros fisiológicos y metabólicos de la rata de laboratorio (Ratus norvegicus)

Mamani, Juan José Vargas

doi:10.33326/26176068.2020.2.1016

“…The copyright holder for this preprint (which this version posted April 11, 2023. ;https://doi.org/10.1101https://doi.org/10. /2023 Although there are many works that have addressed this problem with different degrees of depth (Clancy et al, 2001(Clancy et al, , 2007Donaldson, 1918;Dutta & Sengupta, 2016;Finlay, 2008;Hamdy et al, 2020;Romijn et al, 1991;Semple et al, 2013;Vargas Mamani, 2020;Workman et al, 2013) there is still no agreement regarding the mathematical model that better explains the developmental relationships between both species or how it should be interpreted. Most of these works proposed a linear relationship.…”

Section: Introductionmentioning

confidence: 99%

Divergent Pattern of Development in Rats and Humans

Campos Eusebi,

Iorii,

Presti

et al. 2023

Neurotox Res

1

0

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Rattus norvegicus is the second most used laboratory species and the most widely used model in neuroscience. Nonetheless, there is still no agreement regarding the temporal relationship of development between humans and rats. We addressed this question by examining the time required to reach a set of homologous developmental milestones in both species. With this purpose, a database was generated with data collected through a bibliographic survey. This database was in turn compared with other databases about the same topic present in the literature. Finally, the databases were combined, covering for the first time the entire development of the rat including the prenatal, perinatal, and postnatal periods. This combined database includes 497 individual dates for both species. The developmental relationship between humans .

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Divergent pattern of development in rats and humans

Campos

¹

,

Iorii

²

,

Presti

³

et al. 2023

Preprint

0

View full text Add to dashboard Cite

Rattus norvegicus is the second most used laboratory species and the most widely used model in neuroscience. Nonetheless, there is still no agreement regarding the temporal relationship of development between humans and rats. We addressed this question by examining the time required to reach a set of homologous developmental milestones in both species. With this purpose, a database was generated with data collected through a bibliographic survey. This database was in turn compared with other databases about the same topic present in the literature. Finally, the databases were combined, covering for the first time the entire development of the rat including the prenatal, perinatal, and postnatal periods. This combined database includes 497 individual dates for both species. The developmental relationship between humans and rats was better fit by a logarithmic function than by a linear function. Also, an inflection point close to birth becomes evident after the logarithmic transformation of the data. The predictions of the proposed model were compared with other estimators historically used to calculate developmental relationships, such as growth in brain weight, finding a notorious discrepancy. As development progresses, an increase in the dispersion of the data is observed. Until now, developmental relationships have been interpreted as a univocal equivalence. In this work, is proposed an alternative interpretation where the age of one species is translated into a range of ages in the other.

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Elaboración de la dieta a base de los residuos sólidos orgánicos del mercado Grau para alimentación de ratas del Bioterio

López

¹

,

Quispe²

2022

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En el bioterio de la Universidad Nacional Jorge Basadre Grohmann, se realizó el ensayo para preparar alimento balanceado a base de residuos sólidos orgánicos generados en el mercado modelo Grau de Tacna, en especial de los que abastecen productos hidrobiológicos tales como pescado y los que proveen productos alimenticios como jugos, cuyo contenido nutricional de los insumos cumplió con las expectativas de los parámetros establecidos. Se condujo el experimento en 15 ratas de la especie Rattus norvegicus, de 6 meses de edad, llevándose registros diarios de consumo durante 15 días. Las ratas, como material biológico, presentan una gran demanda de insumos alimenticios, lo que genera un gasto extra para los intereses de la población estudiantil que utiliza ese material en los trabajos de investigación. Las variables experimentales consistieron en elaborar y suministrar proporcionalmente la dieta, por una mezcla a partes iguales de las cáscaras de frutas y verduras en un 40 %, los restos de pescado en un 40 % y con un adicional de pan molido a 20 %. El objetivo es elaborar alimentos balanceados para sustentar la demanda de insumos alimenticios. Este nuevo alimento elaborado de residuos orgánicos promete disminuir los gastos en alimentos y garantizar como fuente de energía y nutricional para las ratas del bioterio.

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Parámetros fisiológicos y metabólicos de la rata de laboratorio (Ratus norvegicus)

Cited by 3 publications

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Divergent Pattern of Development in Rats and Humans

Divergent Pattern of Development in Rats and Humans

Divergent pattern of development in rats and humans

Elaboración de la dieta a base de los residuos sólidos orgánicos del mercado Grau para alimentación de ratas del Bioterio

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