The Paramyxoviruses 1991
DOI: 10.1007/978-1-4615-3790-8_7
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Paramyxovirus RNA Synthesis and P Gene Expression

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Cited by 23 publications
(20 citation statements)
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References 59 publications
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“…The paramyxovirus genome is used with great efficiency, with over 95 % of the RNA encoding the viral proteins. An apparently universal feature of paramyxoviruses is the use of alternative reading frames and RNA editing within their P genes resulting in increased coding capacity of the genome (for review, see Kolakofsky et al, 1990). The translation products of mRNAs transcribed from alternative open reading frames (ORFs) within the P gene appear to be non-structural viral proteins present in the infected cell but absent from the virus particle.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…The paramyxovirus genome is used with great efficiency, with over 95 % of the RNA encoding the viral proteins. An apparently universal feature of paramyxoviruses is the use of alternative reading frames and RNA editing within their P genes resulting in increased coding capacity of the genome (for review, see Kolakofsky et al, 1990). The translation products of mRNAs transcribed from alternative open reading frames (ORFs) within the P gene appear to be non-structural viral proteins present in the infected cell but absent from the virus particle.…”
Section: Introductionmentioning
confidence: 99%
“…Non-templated G residues are inserted at a specific site within the P gene, the consequence of which is the utilization of alternative reading frames during translation (Kolakofsky et aL, 1990). Furthermore, the editing has been found to occur in two distinct patterns.…”
Section: Introductionmentioning
confidence: 99%
“…A similar phenomenon occurred in SV5, although in this instance, editing by the addition of two extra G residues was required to generate the P protein, the V protein being encoded by an mRNA faithfully transcribed from the genome. The insertion is thought to occur as a result of the viral polymerase "stuttering" on a particular sequence within the template [6,20,21]. The 36 kDa…”
mentioning
confidence: 99%
“…Some viral mRNAs encode multiple proteins in distinct reading frames. Among the most striking examples is the PIC gene of paramyxoviruses, which encodes as many as nine distinct polypeptide products in overlapping reading frames that are accessed by alternative initiation codons as well as by RNA editing (Kolakofsky et al, 1991).…”
Section: Protein Synthesis and Modificationmentioning
confidence: 99%