Paramyxoviruses: Parainfluenza Viruses

Marcink, Tara C.; Englund, Janet A.; Moscona, Anne

doi:10.1007/978-1-4939-9544-8_25-1

Cited by 4 publications

(3 citation statements)

References 310 publications

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“…Due to laboratory assay limitations (Table S1), we grouped epidemiologically distinct strains into one incidence time series each for hCoV 229E and hCoV OC43 (hereon hCoV 229E + OC43), hCoV HKU1 and hCoV NL63 (hCoV HKU1 + NL63), hPIV 1 and hPIV 2 (hPIV 1 + 2), hPIV 3 and hPIV 4 (hPIV 3 + 4), hRV, and AdV. hPIV 3 likely comprises most of hPIV 3 + 4 incidence because hPIV 4 infections are detected infrequently and tend to be mild or asymptomatic ( 24 ).…”

Section: Resultsmentioning

confidence: 99%

Human mobility impacts the transmission of common respiratory viruses: A modeling study of the Seattle metropolitan area

Perofsky,

Hansen,

Burstein

et al. 2023

Preprint

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Many studies have used mobile device location data to model SARS-CoV-2 dynamics, yet relationships between mobility behavior and endemic respiratory pathogens are less understood. We studied the impacts of human mobility on the transmission of SARS-CoV-2 and 16 endemic viruses in Seattle over a 4-year period, 2018-2022. Before 2020, school-related foot traffic and large-scale population movements preceded seasonal outbreaks of endemic viruses. Pathogen circulation dropped substantially after the initiation of stay-at-home orders in March 2020. During this period, mobility was a positive, leading indicator of transmission of all endemic viruses and lagged SARS-CoV-2 activity. Mobility was briefly predictive of SARS-CoV-2 transmission when restrictions relaxed in summer 2020 but associations weakened in subsequent waves. The rebound of endemic viruses was heterogeneously timed but exhibited stronger relationships with mobility than SARS-CoV-2. Mobility is most predictive of respiratory virus transmission during periods of dramatic behavioral change, and, to a lesser extent, at the beginning of epidemic waves.Teaser:Human mobility patterns predict the transmission dynamics of common respiratory viruses in pre- and post-pandemic years.

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Section: Resultsmentioning

confidence: 99%

Human mobility impacts the transmission of common respiratory viruses: A modeling study of the Seattle metropolitan area

Perofsky,

Hansen,

Burstein

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Due to assay limitations, epidemiologically distinct strains were grouped into one assay each for hCoV 229E and hCoV OC43, hCoV HKU1 and hCoV NL63, hPIV 1 and hPIV 2, hPIV 3 and hPIV 4, EV, hRV, and AdV. hPIV 3 likely comprises most of hPIV 3 + 4 incidences because hPIV 4 infections are detected infrequently and tend to be mild or asymptomatic 63 .…”

Section: Virologic Surveillance and Laboratory Methodsmentioning

confidence: 99%

Impacts of human mobility on the citywide transmission dynamics of 18 respiratory viruses in pre- and post-COVID-19 pandemic years

Perofsky,

Hansen,

Burstein

et al. 2024

Nat Commun

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Many studies have used mobile device location data to model SARS-CoV-2 dynamics, yet relationships between mobility behavior and endemic respiratory pathogens are less understood. We studied the effects of population mobility on the transmission of 17 endemic viruses and SARS-CoV-2 in Seattle over a 4-year period, 2018-2022. Before 2020, visits to schools and daycares, within-city mixing, and visitor inflow preceded or coincided with seasonal outbreaks of endemic viruses. Pathogen circulation dropped substantially after the initiation of COVID-19 stay-at-home orders in March 2020. During this period, mobility was a positive, leading indicator of transmission of all endemic viruses and lagging and negatively correlated with SARS-CoV-2 activity. Mobility was briefly predictive of SARS-CoV-2 transmission when restrictions relaxed but associations weakened in subsequent waves. The rebound of endemic viruses was heterogeneously timed but exhibited stronger, longer-lasting relationships with mobility than SARS-CoV-2. Overall, mobility is most predictive of respiratory virus transmission during periods of dramatic behavioral change and at the beginning of epidemic waves.

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“…However, several cases of both positive and negative outcomes in nonrandomized studies have been reported. The use of ribavirin medication for the treatment of HPIV infection is not recommended due to the lack of evidence supporting its efficacy in improving clinical outcomes [10,11]. Therefore, there is a need for the development of new antiviral agents that can effectively treat these infections.…”

Section: Introductionmentioning

confidence: 99%

Antiviral Properties of 5‑Sulfamoyl‑1H‑Indole-Linked Spirothiazolidinone Derivatives: A Study on Human Parainfluenza Virus-2

TRAWALLY,

YILMAZ,

ÇELİK

et al. 2024

jrp

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Human parainfluenza viruses (HPIVs) are responsible for a wide range of respiratory infections in humans, particularly in children, the elderly, and immunocompromised individuals. This paper presents a study regarding the antiviral activity of a series of 3-phenyl-5-sulfamoyl-N-(7/8/9-(non)substituted-3-oxo-1-thia-4azaspiro[4.4]non/[4.5]dec-4-yl)-1H-indole-2-carboxamide derivatives against HPIV-2. Our findings suggest the compounds displayed low potency against HPIV-2. Compounds 4 and 8 exhibited the most potent antiviral effects with inhibition of 95.46 and 90.90 % at 10 mg/mL, respectively. Molecular modeling studies were conducted on hemagglutinin-neuraminidase, a crucial druggable target for HPIV, to predict the binding modes of the compounds.

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Paramyxoviruses: Parainfluenza Viruses

Cited by 4 publications

References 310 publications

Human mobility impacts the transmission of common respiratory viruses: A modeling study of the Seattle metropolitan area

Human mobility impacts the transmission of common respiratory viruses: A modeling study of the Seattle metropolitan area

Impacts of human mobility on the citywide transmission dynamics of 18 respiratory viruses in pre- and post-COVID-19 pandemic years

Antiviral Properties of 5‑Sulfamoyl‑1H‑Indole-Linked Spirothiazolidinone Derivatives: A Study on Human Parainfluenza Virus-2

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