Paranasal sinus air suction for immediate pain relief of acute migraine – a randomized, double blind pilot study

Bandara, Senanayake Mudiyanselage Rathnasiri; Samita, S.; Kiridana, A. M.; Ralapanawa, D. M. P. U. K.; Herath, H. M. M. T. B.

doi:10.1186/s12883-019-1486-0

Cited by 4 publications

(13 citation statements)

References 23 publications

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“…Even triptans, if given early (within one hour of migraine) can abort cutaneous allodynia in migraine patients 14 and triptans acts by inhibiting the release of vasoactive peptides, promoting vasoconstriction and reducing the levels of calcitonin gene related peptide. Paranasal air suction might also remove these vasoactive substances, like NO, involved in migraine pathology and reduce the cutaneous allodynia 4 .…”

Section: Discussionmentioning

confidence: 99%

“…A formal informed written consent was taken from all participants who were 18 years of age or above and from legally acceptable representative/guardian/parents of the participants who were below 18 years. The inclusion criteria were similar as the previous study 4 and included patients in the age group of 16-19 years, diagnosed with migraine according to the International Headache Society (IHS) criteria 5 . Patients with more than 3 migraine attacks but not more than 15 attacks per month, who have not taken an acute treatment during the testing period, were selected.…”

Section: Methodsmentioning

confidence: 99%

“…The suction process was carried out similar to our previous research methadology 4 . During this process, nasal and paranasal sinus air were sucked six consecutive times from each nostril.…”

Section: Methodsmentioning

confidence: 99%

“…The previous study showed that sixty-second paranasal air suction could provide an immediate pain relief in acute migraine. The hypothesis in this method was that the suction of air from the paranasal sinuses removes or reduces the synthesis of the neuro and vasoactive air molecules that could be the causative agents for migraine 4 .…”

Section: Introductionmentioning

confidence: 99%

“…Thus, if an easy to use sucker can be made available, all migraine patients can best bene t the pain relief from paranasal sucking. Moreover, in the previous work, we studied only the immediate effect, and effects and side effects within 24 hours after suction were not studied 4 . Accordingly, objective of the current study was to investigate the effectiveness of the recently developed low-pressure portable air sucker on paranasal air suction and providing relief to migraine patients and observe the effects and side effects for 24 hours.…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of Paranasal Air Suction on Acute Migraine Using Portable Air Sucker – A Randomized, Double Blind Study

bandara

Samita

Kiridana

et al. 2021

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Background Migraine is a primary headache disorder and is the most common disabling primary headache disorder that occurs in children and adolescents. A recent study showed that paranasal air suction can provide relief to migraine headache. However, in order to get the maximum benefit out of it, an easy to use effective air sucker should be available. Aiming to fulfil the above requirement, a randomized, double blind control clinical trial was conducted to investigate the efficacy of a recently developed low–pressure portable air sucker.Methods Eighty-six Sri Lankan school children of age 16–19 years with migraine were used for the study. They were randomly allocated into two groups, and one group was subjected to six intermittent ten-second paranasal air suctions using the portable air sucker for 120 seconds. The other group was subjected to placebo air suction (no paranasal air suction). The effect of suction was the key concern but effect of side of headache, type of headache, and gender were also studied with respect to number of response variables. The key response studied was severity of headache. In addition, left and right supraorbital tenderness, photophobia, phonophobia, numbness over the face and scalp, nausea and generalized tiredness/weakness of the body were studied. The measurements on all those variables were made before and after suction, and the statistical analysis was performed based on before and after differences. As a follow–up, patients were monitored for 24-hour period.Results There was a significant reduction in the severity of headache and other migraine symptoms in the treatment group compared to the control group two minutes after the suction. These symptoms did not recur within 24-hour period and there were no significant side effects recorded during the 24-hour observation period.Conclusion This pilot study showed that low–pressure portable air sucker is effective in paranasal air suction, and suction for 120 seconds using the sucker can provide an immediate relief which can last for more than 24-hour period without any side effects.Trail registration Clinical Trial Government Identification Number – 1548/2016.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effectiveness of Paranasal Air Suction on Acute Migraine Using Portable Air Sucker – A Randomized, Double Blind Study

bandara

Samita

Kiridana

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

Effectiveness of paranasal air suction on acute migraine using portable air sucker – a randomized, double blind study

et al. 2021

Self Cite

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Background Migraine is a primary headache disorder and is the most common disabling primary headache disorder that occurs in children and adolescents. A recent study showed that paranasal air suction can provide relief to migraine headache. However, in order to get the maximum benefit out of it, an easy to use effective air sucker should be available. Aiming to fulfil the above requirement, a randomized, double blind control clinical trial was conducted to investigate the efficacy of a recently developed low–pressure portable air sucker. Methods Eighty-six Sri Lankan school children of age 16–19 years with migraine were enrolled for the study. They were randomly allocated into two groups, and one group was subjected to six intermittent ten-second paranasal air suctions using the portable air sucker for 120 s. The other group was subjected to placebo air suction (no paranasal air suction). The effect of suction using portable air sucker was the primary objective but side of headache, type of headache, and gender were also studied as source variables. The primary response studied was severity of headache. In addition, left and right supraorbital tenderness, photophobia, phonophobia, numbness over the face and scalp, nausea and generalized tiredness/weakness of the body were studied. The measurements on all those variables were made before and after suction, and the statistical analysis was performed based on before and after differences. As a follow–up, patients were monitored for 24-h period. Results There was a significant reduction in the severity of headache pain (OR = 25.98, P < 0.0001), which was the primary outcome variable, and other migraine symptoms studied, tenderness (left) (OR = 289.69, P < 0.0001), tenderness (right) (OR > 267.17, P < 0.0001), photophobia (OR = 2115.6, P < 0.0001), phonophobia (OR > 12.62, P < 0.0001) nausea (OR > 515.59, P < 0.0001) and weakness (OR = 549.06, P < 0.0001) except for numbness (OR = 0.747, P = 0.67) in the treatment group compared to the control group 2 min after the suction. These symptoms did not recur within 24-h period and there were no significant side effects recorded during the 24-h observation period. Conclusion This pilot study showed that low–pressure portable air sucker is effective in paranasal air suction, and suction for 120 s using the sucker can provide an immediate relief which can last for more than 24-h period without any side effects. Trail registration Clinical Trial Government Identification Number – 1548/2016. Ethical Clearance Granted Institute – Medical Research Institute, Colombo, Sri Lanka (No 38/2016). Sri Lanka Clinical Trial Registration No: SLCTR/2017/018. Date of registration = 29/ 06/2017. Approval Granting Organization to use the device in the clinical trial– National Medicines Regulatory Authority Sri Lanka (16 Jan 2018), The device won award at Geneva international inventers exhibition in 2016 and President award in 2018 in Sri Lanka. It is a patented device in Sri Lanka and patent number was SLKP/1/18295. All methods were carried out in accordance with CONSORT 2010 guidelines.

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Elevated nitric oxide and carbon monoxide concentration in nasal-paranasal sinus air as a diagnostic tool of migraine: a case – control study

et al. 2021

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Background A recent study showed that 60–s paranasal air suction results in an immediate pain relief in acute migraine. This is the study to assess the Nitric Oxide (NO) and Carbon Monoxide (CO) concentration in nasal-paranasal sinus air of migraine patients and to compare it with healthy controls. Methodology The NO and CO levels of air sucked out from nasal-paranasal sinuses of 20 migraine adolescent and young adults among school students, aged 16 –19 years, and 22 healthy similar aged school students as controls were measured as key responses using a portable NO and a portable CO analyzer. Results Patients had comparatively high values compared to the controls for paranasal NO (both left and right sides), paranasal CO (both left and right sides), Fraction Exhaled NO (FeNO) and Fraction Exhaled CO (FeCO). Patients had median paranasal NO contents of 132.5 ppb and 154 ppb on left and right sides respectively compared to 36 ppb and 34.5 ppb corresponding values in controls (P < 0.0001). Similar pattern was observed with paranasal CO (P < 0.0001). FeNO and FeCO content were also higher in patients (P < 0.0001). Receiver characteristic operating curves of all gas measurements showed that they all could classify patients and controls effectively and NO was the most effective followed by paranasal CO. After air suction, the mean pain scores of general headache and tenderness dropped by a very large margin in migraine patients (P < 0.0001). Conclusions Suctioned out high nasal-paranasal sinus NO and CO levels can be used to distinguish migraine patients from healthy subjects. In fact, suctioned out paranasal NO measurements of both sides with a cutoff point of 50 ppb provided a perfect classification of patients and controls. Increased sinus NO and CO during acute episode of migraine is an observation we had and we agree that further studies are needed to conclude that NO and CO can be a causative molecule for migraine headache. Trail registration Clinical Trial Government Identification Number – 1548/2016. Ethical Clearance Granted Institute – Medical Research Institute, Colombo, Sri Lanka (No 38/2016). Sri Lanka Clinical Trial Registration number: SLCTR/ 2017/018 (29/06/2017). Approval Granting Organization to use the device in the clinical trial– National Medicines Regulatory Authority Sri Lanka (16/06/2018), The device won award at Geneva international inventers exhibition in 2016 and President award in 2018 in Sri Lanka. It is a patented device in Sri Lanka and patent number was SLKP/1/18295. All methods were carried out in accordance with CONSORT 2010 guidelines.

show abstract

Paranasal sinus air suction for immediate pain relief of acute migraine – a randomized, double blind pilot study

Cited by 4 publications

References 23 publications

Effectiveness of Paranasal Air Suction on Acute Migraine Using Portable Air Sucker – A Randomized, Double Blind Study

Effectiveness of Paranasal Air Suction on Acute Migraine Using Portable Air Sucker – A Randomized, Double Blind Study

Effectiveness of paranasal air suction on acute migraine using portable air sucker – a randomized, double blind study

Elevated nitric oxide and carbon monoxide concentration in nasal-paranasal sinus air as a diagnostic tool of migraine: a case – control study

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