Paraneoplastic and non-paraneoplastic retinopathy and optic neuropathy: Evaluation and management

Rahimy, Ehsan; Sarraf, David

doi:10.1016/j.survophthal.2012.09.001

Cited by 168 publications

(150 citation statements)

References 266 publications

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“…6,13,14 CRMP-5 is expressed in the optic nerve, neurons of the central and peripheral nervous systems, oligodendrocytes, and the cytoplasm of SCLC cells. 5,6,10,11,[13][14][15] It has been suggested that autoantibodies generated against the neoplastic CRMP-5 react as a host immune response to normal tissues, resulting in various neuronal disorders.- 6,10,16 In our case, bilateral meningeal enhancement of the optic nerve was evident on MRI, indicating that the main pathogenesis of the optic neuropathy was bilateral perioptic neuritis due to the involvement of oligodendrocytes around the optic nerve. This cause is consistent with preserved central visual acuity, prominent disc swelling, and prompt disappearance of disc swelling in response to the cancer treatment.…”

Section: Discussionmentioning

confidence: 52%

“…6,12,[18][19][20] The visual acuity of our case improved after receiving only chemotherapy and radiotherapy. It was possible that additional immune suppression was not necessary because the amount of antibody decreased with a decrease of the tumour size.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 Most PON patients exhibit many neurological symptoms, including ophthalmoplegia, cerebellar ataxia, seizures, dementia, and various sensory and/ or motor abnormalities. 1,[3][4][5] The various neurological symptoms are believed to be caused by an antitumour immune response 3,6 associated with an increased level of autoantibodies against collapsing response-mediating protein-5 (CRMP-5), 4,5,[7][8][9] which is expressed in the optic nerve, neurons of the central and peripheral nervous systems, oligodendrocytes, the cytoplasm of small cell lung carcinoma (SCLC) cells, or thymomas.- 5,6,[9][10][11] Only a few studies have reported anti-CRMP-5 antibody-positive PON cases that presented with optic neuropathy as the only clinical symptom. Magnetic resonance imaging (MRI) of these cases has been reported as normal, 8,12 or involving unilateral optic nerve involvement.…”

Section: Introductionmentioning

confidence: 99%

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Anti-Collapsing Response-Mediating Protein-5 Antibody–Positive Paraneoplastic Perioptic Neuritis without Typical Neurological Symptoms

Igarashi

Sawamura

Kaburaki

et al. 2016

Neuro-Ophthalmology

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A 68-year-old male presented with blurred vision in both eyes. Ophthalmoscopy revealed bilateral prominent disc swelling and vitritis. No systematic neurological symptoms were observed. Magnetic resonance imaging revealed bilateral meningeal enhancement of the optic nerve. Small cell carcinoma was found, and antibodies against collapsing response-mediating protein-5 (CRMP-5) were detected in the serum. Ophthalmological manifestations disappeared during a decrease in tumour size with treatment for the malignancy. This case report describes this rare case of anti-CRMP-5 antibody-positive paraneoplastic perioptic neuritis without neurological symptoms, showing that prompt diagnosis and timely treatment of the underlying tumour are crucial to prevent increased levels of autoantibodies and irreversible damage to the nervous system. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anti-Collapsing Response-Mediating Protein-5 Antibody–Positive Paraneoplastic Perioptic Neuritis without Typical Neurological Symptoms

Igarashi

Sawamura

Kaburaki

et al. 2016

Neuro-Ophthalmology

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“…La gastroparesia es la más común (105), a diferencia de la pseudoacalasia paraneoplásica, que es muy rara (1 persona en cada 750 000) (106). Alrededor del 30% de los pacientes tienen alteración de la motilidad (107) y manifiestan estreñimiento grave, distensión abdominal, disfagia, náuseas, vómitos (35) y dolor abdominal (78 (96,97).…”

Section: Síndromes Paraneoplásicos Gastrointestinalesunclassified

Síndromes paraneoplásicos en tumores gastrointestinales. Revisión de tema

Paez

Regino

et al. 2017

Rev. Colomb. Gastroenterol.

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ResumenLos síndromes paraneoplásicos representan manifestaciones clínicas que producen los tumores en sitios distantes a ellos y que no están relacionadas físicamente con ellos ni con sus metástasis. Diferentes tumores gastrointestinales pueden presentar síndromes o manifestaciones sistémicas, dermatológicas, hematológi-cas, renales y neurológicas, entre otras. Aquí se ofrece una revisión de esas distintas manifestaciones. Palabras claveSíndrome paraneoplásico, gastrointestinal, tumores. AbstractParaneoplastic syndromes produce tumors at sites distant from themselves and are not physically related to those tumors or to their metastases. Various gastrointestinal tumors may present syndromes or systemic, dermatological, hematological, renal, neurological and other manifestations. This study reviews these manifestations. KeywordsParaneoplastic syndrome, gastrointestinal, tumors.Revisión de tema DOI: https://doi.org/10.22516/25007440.155 INTRODUCCIÓNLos síndromes paraneoplásicos (SPN) son un grupo heterogéneo de manifestaciones clínicas que se producen cuando un tumor provoca un daño en un órgano o sistema distante y que no están relacionadas físicamente con el tumor o sus metástasis (1). Esas alteraciones son independientes del efecto local del tumor, la invasión a otros órga-nos, los déficits nutricionales y las consecuencias derivadas del tratamiento antineoplásico (1, 2). La gran variedad de manifestaciones clínicas es secundaria a la liberación de sustancias por parte de las células neoplásicas malignas (2) que liberan hormonas, péptidos similares a hormonas, factores de crecimiento y citoquinas (1, 2, 3). Adicionalmente, también participan respuestas inmunitarias que, inicialmente, estaban dirigidas contra las nuevas sustancias o antígenos tumorales (oncoantígenos) y que, por reacción cruzada, terminan lesionando tejidos normales (3, 4) y, finalmente, acumulando complejos inmunes (5). Los diferentes SPN se dividen según el órgano o sistema al que afecten y, clásicamente, se clasifican en endocrinometabólicos, dermatológicos, hematológicos, reumatológicos y neurológicos (3). En la presente revisión, se describen los SPN producidos por tumores gastrointestinales (GI).

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“…1 Past studies have found various retinal proteins to be antigenic, which include recoverin, a-enolase, arrestin, and transducin. 2 The inhibition of enolase, a glycolytic enzyme, results in metabolic disruption of retinal cells and the induction of apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Recovery of Outer Retinal Laminations on Optical Coherence Tomography After Treatment of Cancer Associated Retinopathy

Rosenbaum¹

2017

JOJO

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a b s t r a c tPurpose: To report novel optical coherence tomography findings in a case of anti-a-enolase cancer associated retinopathy. Observations: An elderly female presented with bilateral decreased vision and a recent diagnosis of ovarian carcinoma. Optical coherence tomography demonstrated bilateral loss of outer retinal structures and macular edema. Serum testing found antibodies against a-enolase and 82e84 kDa proteins. Outer retinal structures showed recovery, macular edema resolved and repeat anti-retinal antibody testing became negative following cancer therapy and topical difluprednate treatment. Conclusions and importance: Cancer associated retinopathy is a paraneoplastic disease that results in damage to retinal structures through an autoimmune response. The damage is generally considered to be irreversible; however, in rare cases, such as observed here, retinal structures may demonstrate recovery after treatment.

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Paraneoplastic and non-paraneoplastic retinopathy and optic neuropathy: Evaluation and management

Cited by 168 publications

References 266 publications

Anti-Collapsing Response-Mediating Protein-5 Antibody–Positive Paraneoplastic Perioptic Neuritis without Typical Neurological Symptoms

Anti-Collapsing Response-Mediating Protein-5 Antibody–Positive Paraneoplastic Perioptic Neuritis without Typical Neurological Symptoms

Síndromes paraneoplásicos en tumores gastrointestinales. Revisión de tema

Recovery of Outer Retinal Laminations on Optical Coherence Tomography After Treatment of Cancer Associated Retinopathy

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