2019
DOI: 10.1007/s11864-019-0661-2
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Paraneoplastic and Therapy-Related Immune Complications in Thymic Malignancies

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Cited by 32 publications
(60 citation statements)
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“…Immature and TET-derived thymocytes that have escaped self-tolerance and become auto-active may be the mechanism for the development of MG in patients with TETs [16]. ICI therapy can further activate T lymphocytes and strength the autoimmune activity of the cells, given the fact that TET patients are more susceptible to developing autoimmune disorders, which makes thymoma patients more likely than patients with other cancers to experience multiple irAEs [8,13]. Even a higher dose of glucocorticoid and IVIG were administered immediately after diagnosis of myasthenic crisis, they could not reverse the outcome due to the extremely worsening situation.…”
Section: Discussionmentioning
confidence: 99%
“…Immature and TET-derived thymocytes that have escaped self-tolerance and become auto-active may be the mechanism for the development of MG in patients with TETs [16]. ICI therapy can further activate T lymphocytes and strength the autoimmune activity of the cells, given the fact that TET patients are more susceptible to developing autoimmune disorders, which makes thymoma patients more likely than patients with other cancers to experience multiple irAEs [8,13]. Even a higher dose of glucocorticoid and IVIG were administered immediately after diagnosis of myasthenic crisis, they could not reverse the outcome due to the extremely worsening situation.…”
Section: Discussionmentioning
confidence: 99%
“…The conclusion that MG-related thymoma patients have more favorable prognosis than patients without MG has been controversial (Filosso et al, 2015;Lippner, Lewis, Robinson, & Katsumoto, 2019).…”
Section: Discussionmentioning
confidence: 99%
“…The conclusion that MG‐related thymoma patients have more favorable prognosis than patients without MG has been controversial (Filosso et al, 2015; Lippner, Lewis, Robinson, & Katsumoto, 2019). Our results regarding OS manifested that patients without MG tended to have better survival, although no significant difference was identified.…”
Section: Discussionmentioning
confidence: 99%
“…Paraneoplastic disorders generally result from production of hormones, cytokines or peptides by tumor cells that lead to metabolic derangements; other mechanisms may include cross-reaction between tumor neoantigens and tissue-related antigens, with peripheral induction of autoantibody production stimulated by the presence of the tumor [26]. Thus, successful treatment of the underlying tumor often improves paraneoplastic syndromes, such as in neurological disorders like Lambert-Eaton myasthenia syndrome which is caused by autoantibodies to voltage-gated calcium channels in the presynaptic neuronal cell membrane, and often observed in thymic carcinomas [27].…”
Section: Pathogenesis Of Autoimmunity In Thymic Epithelial Tumorsmentioning
confidence: 99%