Paraneoplastic bullous pemphigoid – A sign of clear cell renal carcinoma

Jackson, Stuart; Koestenbauer, Jakob; Carroll, Adam P.; Oo, Than-Htike; Chou, Shaun; Indrajit, Balasubramaniam

doi:10.1016/j.eucr.2020.101119

Cited by 8 publications

(7 citation statements)

References 4 publications

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“…There were no differences in clinical characteristics, symptoms, or illness severity between patients with and without cancer in the current study cohort. This is in contrast to several previous reports of unusual clinical BP variants (atypical presentation and refractory disease) in patients with associated malignancies (20,21,(38)(39)(40).…”

Section: Discussioncontrasting

confidence: 99%

“…Some studies have shown an association with malignancies (either solid tumours and/or haematological malignant disorders) (14)(15)(16)(17), while others claim that this association is coincidental and may be explained by confounding factors, such as age (18,19). Several reports have described unusual clinical BP variants in patients who also have malignancies (20,21). Because the prevalence of BP varies by geographical area and ethnicity (22,23), it is probable that comorbidities, such as malignancy, will also vary.…”

Section: Significancementioning

confidence: 99%

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Prevalence, Spectrum and Clinical Implications of Malignancies in Patients with Bullous Pemphigoid

et al. 2023

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Current research on the malignancy rate and spectrum of malignancies in patients with bullous pemphigoid is contradictory. The aims of this study were to determine the prevalence and spectrum of malignancy in patients with bullous pemphigoid and to compare demographic, clinical, therapeutic and outcome data between bullous pemphigoid patients with and without malignancy. This retrospective cohort study enrolled 335 patients (194 women and 141 men; mean age at diagnosis of bullous pemphigoid 77.5 ± 12 years) followed up at an Israeli tertiary centre between January 2009 and December 2019: 107 (32%) had malignancy and 228 (68%) did not. Malignancy occurred before and after bullous pemphigoid diagnosis in 82 (77%) and 25 (23%) patients, respectively. Bullous pemphigoid patients with cancer were older (p = 0.02) and had a higher mortality rate (p < 0.0001) than those without malignancy. The 2 groups did not differ in terms of sex, comorbidities, or clinical characteristics. Those who developed malignancy before bullous pemphigoid were younger than those who developed malignancy after bullous pemphigoid (mean age 69.3 vs 82.4 years, p < 0.0001). Overall malignancy rates did not differ between patients with bullous pemphigoid and the general population; therefore, comprehensive malignancy workup may be unnecessary. However, patients with bullous pemphigoid had a greater risk of melanoma (10.7% vs 4.3%, p = 0.0005); therefore, routine skin screening may be recommended.

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Section: Discussioncontrasting

confidence: 99%

Section: Significancementioning

confidence: 99%

Prevalence, Spectrum and Clinical Implications of Malignancies in Patients with Bullous Pemphigoid

et al. 2023

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“…The diagnosis is confirmed by skin histology and direct immunofluorescence study [4]. The association of a bullous pemphigoid with cancer disease is still controversial; there are reports of improvement of bullous lesions after treatment of the tumor, which might suggest a causal relationship [3,4]. In our observation, the regression of dermatosis after tumor resection argues in favour of paraneoplastic characters.…”

Section: Discussionsupporting

confidence: 64%

“…In its classic form, it is clinically characterized by a bullous, pruritic dermatosis, made up of tense bullae over erythematous, symmetrical plaques, without mucosal damage or atrophic scarring, with negative Nikolsky sign. The blood examination shows frequently hyper eosinophilia, sometimes very significant [3]. Our patient had moderate eosinophilia.…”

Section: Discussionmentioning

confidence: 53%

Paraneoplastic Bullous Pemphigoid: Myth or Reality? A Case Report

Dahhouki¹,

Mrabat²,

Douhi³

et al. 2020

JDR

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“…Similarly, membranous deposition of IgG immune The identification of other smaller proteins targeted by PAMPS may be important signaling proteins that are yet to be determined [110]. Patients with small subsets of autoantibodies may cause a humoral effect with specific skin lesions, i.e., pemphigus-like lesion in paraneoplastic pemphigus [117], pemphigoid-like lesion in paraneoplastic bullous pemphigoid [118], or overlapping subepidermal and intraepidermal vesicles in paraneoplastic lichen ruber pemphigoides [119], etc. Patients may also have full spectrum of autoantibodies that trigger both humoral and cellular responses.…”

Section: Defining Autoimmune Reactionmentioning

confidence: 99%

COVID-19 Infection: The Virus and Its Origin, the Variants, the Immune Defense, the Multiorgan Autoimmune Reactions, and the Targeted Treatments

Nguyen¹,

Chan²

2022

AID

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Background: SARS-CoV-2, the virus responsible for the current COVID-19 infection pandemic, has caused substantial damage and negative impacts in the world, including physical sickness, mental illness, death, society lock down, work interruption, and productivity reduction. From the onset in early 2020, the pandemic has not yet totally subsided as of July 2022. Although great efforts have been made to understand the nature of this pandemic by the medical and scientific communities, a comprehensive review of this pandemic has not been reported. Purpose: We aimed to perform a thorough review of the subject in order to come to a better understanding of the origin of the virus, its mutations and their corresponding health effects, its pathophysiology, and its responses to therapeutic intervention. A more comprehensive set of data on these subject matters, if available, would give healthcare providers a valuable tool in formulating the best methods to respond to the current disease and prevent the disease from spreading in the future. Method: An extensive literature search on the subjects of COVID-19 was conducted regarding the possible origin of the viral pathogen, its evolutionary changes and health impacts, the world's responses to COVID-19 and outcomes of their responses, and healthcare professional's actions to understand and manage the disease and the results of their actions. To gather these data, websites of PubMed and Google Scholar were utilized for the search with the following keywords: Pandemic, COVID-19, coronavirus, SARS, SARS-CoV, SARS-CoV-2, origin, pathogenesis, and treatment. Results: Our review revealed data that How to cite this paper: Nguyen, V.T. and Chan, L.S. (2022) COVID-19 Infection: The Virus and Its Origin, the Variants, the Immune Defense, the Multiorgan Autoimmune Reactions, and the Targeted Treatments. Advances in Infectious Diseases, 12, 568-631.

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Paraneoplastic bullous pemphigoid – A sign of clear cell renal carcinoma

Cited by 8 publications

References 4 publications

Prevalence, Spectrum and Clinical Implications of Malignancies in Patients with Bullous Pemphigoid

Prevalence, Spectrum and Clinical Implications of Malignancies in Patients with Bullous Pemphigoid

Paraneoplastic Bullous Pemphigoid: Myth or Reality? A Case Report

COVID-19 Infection: The Virus and Its Origin, the Variants, the Immune Defense, the Multiorgan Autoimmune Reactions, and the Targeted Treatments

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