Paraneoplastic cerebellar and brainstem disorders

Abbatemarco, Justin R.; Vedeler, Christian A.; Greenlee, John E.

doi:10.1016/b978-0-12-823912-4.00030-x

Handbook of Clinical Neurology

2024

DOI: 10.1016/b978-0-12-823912-4.00030-x

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Paraneoplastic cerebellar and brainstem disorders

Justin R. Abbatemarco,

Christian A. Vedeler,

John E. Greenlee

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2024

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Cited by 1 publication

References 146 publications

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CDR2 is a dynein adaptor recruited by kinectin to regulate ER sheet organization

Teixeira,

Singh,

Gama

et al. 2024

Preprint

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The endoplasmic reticulum (ER) relies on the microtubule cytoskeleton for distribution and re-modelling of its extended membrane network, but how microtubule-based motors contribute to ER organization remains unclear. Using biochemical and cell-based assays, we identify cerebellar degeneration-related protein 2 (CDR2) and its paralog CDR2-like (CDR2L), onconeural antigens with poorly understood functions, as ER adaptors for cytoplasmic dynein-1 (dynein). We demonstrate that CDR2 is recruited by the integral ER membrane protein kinectin (KTN1) and that double knockout of CDR2 and CDR2L enhances KTN1-dependent ER sheet stacking, reversal of which by exogenous CDR2 requires its dynein-binding CC1 box motif. Exogenous CDR2 expression additionally promotes CC1 box-dependent clustering of ER sheets near centrosomes. CDR2 competes with the eEF1Bbeta subunit of translation elongation factor 1 for binding to KTN1, and eEF1Bbeta knockdown increases endogenous CDR2 levels on ER sheets, inducing their centrosome-proximal clustering. Our study describes a novel molecular pathway that implicates dynein in ER sheet organization and may be involved in the pathogenesis of paraneoplastic cerebellar degeneration.

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CDR2 is a dynein adaptor recruited by kinectin to regulate ER sheet organization

Teixeira,

Singh,

Gama

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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Paraneoplastic cerebellar and brainstem disorders

Cited by 1 publication

References 146 publications

CDR2 is a dynein adaptor recruited by kinectin to regulate ER sheet organization

CDR2 is a dynein adaptor recruited by kinectin to regulate ER sheet organization

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