Paraneoplastic cerebellar ataxia with central hypoventilation

Kunchok, Amy; Barnes, David J.; Boyer, Michael; Hálmagyi, G. Michael

doi:10.1212/nxi.0000000000000305

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…More rarely, it develops in association with extra-thoracic neoplasms such as neuroblastoma or intestinal, prostate, breast, bladder, and ovary carcinomas ( 18 ). It has also been proved that patients with positive anti-Hu antibodies can manifest various neurological disorders, including sensory neuropathy, cerebellar ataxia ( 19 ), limbic encephalitis ( 20 ), brainstem encephalitis ( 21 ), myelitis, or intestinal pseudo-obstruction ( 22 ).…”

Section: Discussionmentioning

confidence: 99%

Persistent pain and numbness in the extremities of an adult due to paraneoplastic peripheral neuropathy caused by olfactory neuroblastoma: A case report

Liang

Wang²,

Sun³

et al. 2023

Front. Neurol.

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BackgroundParaneoplastic peripheral neuropathy (PPN) caused by olfactory neuroblastoma (ONB) has not yet been reported.Case reportWe present a rare case of an adult who hospitalized repeatedly over the past 9 months for persistent pain and numbness in the limbs. This patient was initially diagnosed with chronic inflammatory demyelinating polyneuropathy (CIDP) and treated accordingly, but neurological symptoms did not improve significantly. After this admission, FDG-PET/CT showed focal hypermetabolism of a soft-tissue mass in the nasal cavity, and further lesion biopsy suggested ONB. Combined with positive serum anti-Hu antibody, the diagnosis of PPN associated with ONB was eventually made. Furthermore, the patient's neurological symptoms were relieved after removal of the primary tumor, confirming the accuracy of the diagnosis.ConclusionOur case not only expanded the clinical characteristics of ONB but also highlighted the importance of early and comprehensive tumor screening for the diagnosis of PPN.

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Section: Discussionmentioning

confidence: 99%

Persistent pain and numbness in the extremities of an adult due to paraneoplastic peripheral neuropathy caused by olfactory neuroblastoma: A case report

Liang

Wang²,

Sun³

et al. 2023

Front. Neurol.

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Beatmung bei Störungen der Atemregulation

Hassanpour

Vedadinezhad

Groß

2020

Neurologische Beatmungsmedizin

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A 58-Year-Old Man With Episodic Hypercapnic Respiratory Failure

Marsters

Chu

Alohaly

et al. 2021

Chest

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A 58-year-old man presented to the ED with a 1-week history of progressive weight loss, generalized weakness, unsteadiness, and dizziness. In hospital, he experienced a witnessed episode of loss of consciousness with no observable respirations that lasted for 15 minutes. His arterial blood gas demonstrated hypercapnic respiratory failure, and he required mask ventilation and vasoactive medications. Similar episodes occurred several more times over the course of the night that required the patient to be intubated. The paroxysmal episodes persisted necessitating continued invasive ventilatory support and admission to the ICU. The episodes occurred in both awake and asleep states and required the ventilator settings to dictate a minimum rate, but minimal ventilatory support otherwise. Further history revealed other symptomatic complaints of vertigo, dysphagia, and hypophonia that had progressed over a 2-month period. The patient's medical history was pertinent for a diagnosis of prostatic carcinoma 3 years previously that was found to be castrate resistant. He had metastases to his hip, ribs, and thoracic spine. Previous treatments had included bicalutamide, docetaxel, and abiraterone; he was receiving leuprolide therapy on presentation.

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Paraneoplastic cerebellar ataxia with central hypoventilation

Cited by 3 publications

References 7 publications

Persistent pain and numbness in the extremities of an adult due to paraneoplastic peripheral neuropathy caused by olfactory neuroblastoma: A case report

Persistent pain and numbness in the extremities of an adult due to paraneoplastic peripheral neuropathy caused by olfactory neuroblastoma: A case report

Beatmung bei Störungen der Atemregulation

A 58-Year-Old Man With Episodic Hypercapnic Respiratory Failure

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