Paraneoplastic cerebellar degeneration with fallopian tube adenocarcinoma

Anti-Yo and anti-glutamic acid decarboxylase antibodies presenting in carcinoma of the uterus with paraneoplastic cerebellar degeneration: a case report

“…PCDs have however been associated with fallopian tube adenocarcinoma [5]. To the best of our knowledge this is the first case of clear cell endometrial carcinoma with anti-Yo antibodies in serum and CSF, associated with anti-GAD antibodies in serum and CSF; observations that extend the known associations and relationships of both of these antibodies and indicates the importance of an aberrant immune response in PCD.…”

Paraneoplastic cerebellar degeneration in a patient with a primary fallopian tube adenocarcinoma. A case report and brief review

“…Indeed, the majority of the serous tumors appear to originate from dysplastic lesions in the distal fallopian tube, and what has been traditionally considered ovarian cancer may in fact be tubal in origin (Erickson et al, 2013), different from primary peritoneal adenocarcinoma (Sørensen et al, 2015). Despite this hypothesis, there are few reports of PCD in association with fallopian tube cancer (Tanaka et al, 1992, Tanaka et al, 2005, Matsushita et al, 1998, López et al, 2013). The association between ovarian adenocarcinoma and PCD has been estimated to affect a small proportion of women with this type of cancer (Darnell and Posner, 2003), but the numbers may vary significantly (see Dalmau and Rosenfeld, 2008).…”

“…Despite surgical removal, the neurological syndrome remained unaltered. Fallopian tube cancer has been rarely associated with PCD (Tanaka et al, 1992, Tanaka et al, 2005), even though it has been hypothesized that epithelial ovarian adenocarcinomas may actually arise from the fallopian tube (Erickson et al, 2013). …”

Paraneoplastic Cerebellar Degeneration as Initial Presentation of Papillary Carcinoma of the Fallopian Tube: Evaluation and Usefulness of 18F-FDG PET-CT. Case Report and Literature Review

“…PCD occurs predominantly in patients with gynecological carcinomas (ovarian and breast cancer), Hodgkin lymphoma, and small cell carcinoma of the kidney or lung [2,9]. The related symptoms are usually ataxia, dysarthria, tremor, nystagmus, vertigo, and diplopia [3,8].…”

“…The related symptoms are usually ataxia, dysarthria, tremor, nystagmus, vertigo, and diplopia [3,8]. Not all gynecological cancers present as paraneoplastic neurological syndrome; however, in a clinical presentation consistent with a paraneoplastic neurological syndrome, the chances of underlying malignancy are very high [9].…”