Paraneoplastic Guillain-Barré Syndrome in Small Cell Lung Cancer

Kim, Moon Ho; Hwang, Min Sik; Park, Yoon Kyoo; Park, Yerim; Ahn, Y.; Oh, Heekuck; Ahn, Hee‐Sung

doi:10.1159/000437295

Cited by 13 publications

(13 citation statements)

References 16 publications

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“…It has been hypothesized that tumors could produce antigens that cause autoimmunity against the peripheral nerves; this is seen in notable paraneoplastic syndromes that affect the nervous system [ 15 ]. Another hypothesis suggests that the relative immunosuppression related to cancer or its treatment could lead to GBS through immune regulation defects [ 15 ]. The underpinnings of the possible immune-mediated mechanisms remain unclear at the present time.…”

Section: Discussionmentioning

confidence: 99%

Guillain-Barre Syndrome Amid Osteosarcoma Treatment: A Therapeutic Dilemma and Literature Review

Suárez¹,

Deng²,

Silva³

et al. 2021

Cureus

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Guillain-Barre syndrome (GBS) is a clinical syndrome with multiple variants. GBS is defined as an acute demyelinating polyneuropathy commonly preceded by infection (bacterial or viral), trauma, or inflammatory processes, which triggers an autoimmune response that affects the peripheral nervous system. This case report describes a patient with high-grade osteosarcoma that completed neoadjuvant chemotherapy and underwent surgical resection with no immediate complications. Fourteen days after the surgery, the patient developed an acute inflammatory demyelinating polyradiculopathy consistent with GBS. As the five-year survival without chemotherapy is only around 20%, this challenging clinical scenario raised questions regarding adjuvant chemotherapy's safe completion in this setting.

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Section: Discussionmentioning

confidence: 99%

Guillain-Barre Syndrome Amid Osteosarcoma Treatment: A Therapeutic Dilemma and Literature Review

Suárez¹,

Deng²,

Silva³

et al. 2021

Cureus

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“…There are currently nine reported cases involving lung cancer [ 3 - 11 ]. Of the reported cases, seven involve small cell lung cancer [ 3 , 5 - 9 , 11 ] and two involve adenocarcinoma of the lung [ 4 , 10 ]. There is only one other documented case involving squamous cell, however the primary tumor originated from the mandible [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

A Case of Paraneoplastic Guillain-Barré Syndrome Associated with Squamous Cell Carcinoma of the Lung

Liu

Baldinger

et al. 2018

Cureus

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We report a case of a 61-year-old man with a history of squamous cell carcinoma of the lung presenting with rapidly progressive symmetric ascending weakness with areflexia. The weakness was quickly followed by respiratory decompensation requiring intubation. Lumbar puncture yielded cerebrospinal fluid with elevated protein (177 mg/dL), normal glucose (61 mg/dL), normal red blood cell count (0 per/µl), and normal white blood cell count (0 per/µL). Emergent magnetic resonance imaging of cervical, thoracic, and lumbar spine did not show evidence of metastatic disease, fracture, subluxation, or other causes of cord compression. The patient was diagnosed with acute inflammatory polyneuropathy, also known as Guillain-Barré syndrome. Despite treatment with a five-day course of intravenous immunoglobulin and a subsequent five-day course of plasmapheresis, the patient did not recover respiratory function and died 48 days after diagnosis. To our knowledge, this is the first documented case of Guillain-Barré occurring concomitantly with squamous cell carcinoma of the lung.

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“…Based on the expected number of malignancies, the calculated odds ratio of GBS incidence was 2.4, suggesting a possible correlation between some cases of GBS and cancer ( 14 ). To our knowledge, 12 cases with GBS or GB-like syndromes associated with lung cancer have been reported ( 11 , 15 - 25 ). Interestingly, anti-ganglioside antibody was detected in only one case ( 11 ).…”

Section: Discussionmentioning

confidence: 99%

Subacute Sensorimotor Neuropathy Accompanied by Anti-ganglioside GM1 Antibody in a Patient with Lung Cancer

et al. 2018

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A 66-year-old man presented with subacute sensorimotor neuropathy in association with small cell lung cancer. Tests for the anti-ganglioside antibody GM1-IgM were positive. Chemotherapy and intravenous immunoglobulin treatment led to a slight improvement in neurological symptoms. Four additional cases of neuropathy accompanied by anti-ganglioside antibody and lung cancer have been reported. The most commonly reported pattern was subacute sensorimotor neuropathy. Patients died from cancer progression after 5 to 18 months. There is evidence that anti-ganglioside antibody inhibits tumor progression, prolonging the patient survival. However, severe neurological disturbance may offset the survival benefit of anti-ganglioside antibody in patients with paraneoplastic neurological syndrome.

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Paraneoplastic Guillain-Barré Syndrome in Small Cell Lung Cancer

Cited by 13 publications

References 16 publications

Guillain-Barre Syndrome Amid Osteosarcoma Treatment: A Therapeutic Dilemma and Literature Review

Guillain-Barre Syndrome Amid Osteosarcoma Treatment: A Therapeutic Dilemma and Literature Review

A Case of Paraneoplastic Guillain-Barré Syndrome Associated with Squamous Cell Carcinoma of the Lung

Subacute Sensorimotor Neuropathy Accompanied by Anti-ganglioside GM1 Antibody in a Patient with Lung Cancer

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