Paraneoplastic limbic encephalitis associated with ovarian teratoma
Search citation statements
Paper Sections
Citation Types
Year Published
Publication Types
Relationship
Authors
Journals
Cited by 1 publication
References 11 publications
Abstract.A 27-year-old female patient presented with a 3-month history of bilateral orbital and facial edema accompanied by skin erythema and heliotrope rash. The left lesion was more critical than the right. Limb muscles were occasionally sore. On physical examination, scattered hemorrhagic rashes were observed on the patient's face and neck. Upon laboratory testing, creatine kinase (CK) was markedly elevated at 1,543.2 U/l, while CK-MB isoenzyme (27.4 U/l), α-hydroxybutyric dehydrogenase (188.4 U/l) and aspartate aminotransferase (65.3 U/l) were marginally elevated. The patient was diagnosed with dermatomyositis due to the dermatological features and elevated CK. Cancer marker analysis revealed positivity for carbohydrate antigen 125 (68.15 U/ml). Magnetic resonance imaging revealed thickening of the soft tissue of the left eyelid; furthermore, concurrent long T1-and T2-weighted signals (fat saturation) were compatible with inflammatory infiltration. Non-enhanced computed tomography identified that the right accessory region (right ovary and fallopian tube) had a cystic mass with a significant fat component and thickening of the anterior uterine wall. Gynecological ultrasound findings indicated an ovarian teratoma (8.7x7.8x9.3 cm) and uterine myoma (3.6x3.1 cm). The patient's dermatological symptoms and laboratory results were significantly relieved one week after surgical removal of the teratoma with the aid of hydrocortisone, methylprednisolone and methotrexate therapy. IntroductionDermatomyositis is a type of idiopathic inflammatory myopathy (1). Bohan and Peter (1) proposed five major criteria for the diagnosis dermatomyositis and another idiopathic inflammatory myopathy, polymyositis, in 1975: Progressive symmetrical weakness, muscle-biopsy evidence, including muscle fiber swelling, absence of striations and muscle fibers revealing vacuolar degeneration, elevated enzymes in skeletal muscle serum, abnormal electromyogram and dermatological features. Bohan and Peter (1) also suggested five subsets of myositis: Polymyositis, dermatomyositis, dermatomyositis associated with neoplasia, child dermatomyositis associated with vasculitis and polymyositis or dermatomyositis with associated collagen-vascular disease. Subsequent to this, Saoud et al (2) recognized an additional subset: Amyopathic dermatomyositis. Furthermore, Callen (3) previously reported that dermatomyositis is associated with malignant tumors. Teratomas are a type of germ cell tumor comprising well-differentiated tissues and 3 germ cell layers: Ectoderm, mesoderm and endoderm. They are divided into mature (benign) and immature (malignant) teratomas, and dermatomyositis may be associated with malignant or benign tumors. The current study presents a case of dermatomyositis accompanied by a benign ovarian teratoma. Case reportA 27-year-old female patient with a 3-month history of bilateral orbital and facial edema accompanied by skin erythema and rash accepted treatment at the Department of Rheumatology of the Affiliated Hospital of Qingdao Universit...
Abstract.A 27-year-old female patient presented with a 3-month history of bilateral orbital and facial edema accompanied by skin erythema and heliotrope rash. The left lesion was more critical than the right. Limb muscles were occasionally sore. On physical examination, scattered hemorrhagic rashes were observed on the patient's face and neck. Upon laboratory testing, creatine kinase (CK) was markedly elevated at 1,543.2 U/l, while CK-MB isoenzyme (27.4 U/l), α-hydroxybutyric dehydrogenase (188.4 U/l) and aspartate aminotransferase (65.3 U/l) were marginally elevated. The patient was diagnosed with dermatomyositis due to the dermatological features and elevated CK. Cancer marker analysis revealed positivity for carbohydrate antigen 125 (68.15 U/ml). Magnetic resonance imaging revealed thickening of the soft tissue of the left eyelid; furthermore, concurrent long T1-and T2-weighted signals (fat saturation) were compatible with inflammatory infiltration. Non-enhanced computed tomography identified that the right accessory region (right ovary and fallopian tube) had a cystic mass with a significant fat component and thickening of the anterior uterine wall. Gynecological ultrasound findings indicated an ovarian teratoma (8.7x7.8x9.3 cm) and uterine myoma (3.6x3.1 cm). The patient's dermatological symptoms and laboratory results were significantly relieved one week after surgical removal of the teratoma with the aid of hydrocortisone, methylprednisolone and methotrexate therapy. IntroductionDermatomyositis is a type of idiopathic inflammatory myopathy (1). Bohan and Peter (1) proposed five major criteria for the diagnosis dermatomyositis and another idiopathic inflammatory myopathy, polymyositis, in 1975: Progressive symmetrical weakness, muscle-biopsy evidence, including muscle fiber swelling, absence of striations and muscle fibers revealing vacuolar degeneration, elevated enzymes in skeletal muscle serum, abnormal electromyogram and dermatological features. Bohan and Peter (1) also suggested five subsets of myositis: Polymyositis, dermatomyositis, dermatomyositis associated with neoplasia, child dermatomyositis associated with vasculitis and polymyositis or dermatomyositis with associated collagen-vascular disease. Subsequent to this, Saoud et al (2) recognized an additional subset: Amyopathic dermatomyositis. Furthermore, Callen (3) previously reported that dermatomyositis is associated with malignant tumors. Teratomas are a type of germ cell tumor comprising well-differentiated tissues and 3 germ cell layers: Ectoderm, mesoderm and endoderm. They are divided into mature (benign) and immature (malignant) teratomas, and dermatomyositis may be associated with malignant or benign tumors. The current study presents a case of dermatomyositis accompanied by a benign ovarian teratoma. Case reportA 27-year-old female patient with a 3-month history of bilateral orbital and facial edema accompanied by skin erythema and rash accepted treatment at the Department of Rheumatology of the Affiliated Hospital of Qingdao Universit...
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
Contact Info
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Product
Resources
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2025 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.
