Paraneoplastic Manifestations of Lymphoma

Hagler, Karl T.; Lynch, James W.

doi:10.3816/clm.2004.n.007

Cited by 47 publications

(50 citation statements)

References 117 publications

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“…Los 11 meses anteriores pueden explicarse como un síndrome paraneoplásico, caracterizado por, como se denominó, una reacción sarcoide. Sin duda, la presencia de granulomas también son una rareza dentro de los numerosos síndromes paraneoplásicos que los linfomas pueden desarrollar 5 . Pero, como Malcolm Gladwell consistentemente describe en su libro -Outliers: The Story of Success-, al outlier debe intentar comprendérsele siempre en perspectiva 6 .…”

Section: Sr Editorunclassified

Interpretando un caso atípico: el tiempo de evolución determina el diagnóstico e impacta en el pronóstico de los linfomas no Hodgkin

Ernst

Escobar

2018

Rev. méd. Chile

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Section: Sr Editorunclassified

Interpretando un caso atípico: el tiempo de evolución determina el diagnóstico e impacta en el pronóstico de los linfomas no Hodgkin

Ernst

Escobar

2018

Rev. méd. Chile

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“…7 There are only a few case reports of AIHA and ITP in pediatric HL. Ertem et al published a case of autoimmune bi-cytopenia as a presentation of Hodgkin disease in a 6-year-old boy, one of the two case reports where AIHA and ITP co-occurred in HL.…”

Section: Hematologic Syndromesmentioning

confidence: 99%

“…7 In children, nephrotic syndrome (NS) is most commonly described in the context of HL although the incidence remains less than 1%. 11,24 More than half of the cases of NS occurred prior to or concurrent with the diagnosis of HL.…”

Section: Renal Syndromesmentioning

confidence: 99%

“…PNS in patients with HL can affect multiple organs including the neurologic, hematologic, endocrine, renal, and hepatic systems. [5][6][7] In addition to the above, hepatic, dermatologic, and rheumatologic manifestations have also been described in adults. 3,6,[8][9][10][11] PNS in children with HL is relatively rare, with few published case reports and case series in this population.…”

mentioning

confidence: 99%

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Paraneoplastic Syndromes in Children with Hodgkin Lymphoma

Betcherman¹,

Punnett²

2017

Oncology &Amp; Hematology Review (US)

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Paraneoplastic syndromes (PNS) refer to a phenomenon whereby certain malignancies manifest as symptoms not directly related to the tumor itself. PNS has been described in association with Hodgkin lymphoma (HL) in adults and children and may affect a number of organ systems. The pathophysiology is variable and in many cases is not well understood. Specific paraneoplastic antibodies have been isolated in some syndromes, though are not required for the diagnosis. The two best described for HL are the anti-Tr and anti-mGluR5 antibodies identified in some cases of limbic encephalitis and cerebellar degeneration respectively. A high index of suspicion for underlying malignancy is necessary when recognizing these clinical syndromes to avoid a diagnostic delay. Successful treatment of the HL often reverses the manifestations of PNS although organ function at diagnosis may limit therapeutic options. Some patients suffer devastating complications of their PNS.

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“…[16][17] In 70%-80% of the acute ATLL form, the patients develop the humoral hypercalcemia of malignancy (HHM), a paraneoplastic syndrome characterized by hypercalcemia, osteoporosis and osteolytic lesions. [13][14][15]18,19 This suggests that there should be released or expressed molecules in ATLL cells performing a crucial role in HHM etiology. 20 The HHM of patients with acute ATLL is caused by mechanisms that act synergistically, affecting directly or indirectly the osteoclastic differentiation.…”

Section: Calcium Disorders Hypercalcemia and Osteoporosismentioning

confidence: 99%

Endocrine and metabolic disorders in HTLV-1 infected patients

Alves¹,

Dourado²

2010

Braz J Infect Dis

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Human T-cell leukemia virus type 1 (HTLV-1) infection is endemic in Japan and several countries in South America, Caribbean and Africa. Endocrine and metabolic disorders have been variably reported to be associated with human T-cell leukemia virus type 1 (HTLV-1) infection. Therefore, the aim of this article was to critically evaluate the current knowledge of the endocrine and metabolic disorders associated with HTLV-1 infection. The literature search used PubMed, Web of Science, and LILACS databases in the past 10 years, utilizing, in various combinations, the following keywords: HTLV-1, adult T-cell leukemia, diabetes mellitus, GLUT-1, osteoporosis, hypercalcemia, autoimmune thyroid disorders, diabetes insipidus, inappropriate antidiuretic hormone secretion; pseudohypoparathyroidism; pseudopseudohypoparathyroidism. The proven endocrine manifestations of the HTLV-1 infection are calcium disorders which occur in some patients with acute HTLV-1/Adult T-cell leukemia/lymphoma. The few reports about thyroid, parathyroid, antidiuretic hormone and diabetes mellitus are insuffi cient to prove a causal association with HTLV-1 infection. The evidence for an association between endocrine disorders and HTLV-1 infection in general, and in asymptomatic patients is lacking. Given all these uncertainties, the endocrine expression of the HTLV-1 infection composes a promising research line for understanding the pathophysiology of this infection.

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Paraneoplastic Manifestations of Lymphoma

Cited by 47 publications

References 117 publications

Interpretando un caso atípico: el tiempo de evolución determina el diagnóstico e impacta en el pronóstico de los linfomas no Hodgkin

Interpretando un caso atípico: el tiempo de evolución determina el diagnóstico e impacta en el pronóstico de los linfomas no Hodgkin

Paraneoplastic Syndromes in Children with Hodgkin Lymphoma

Endocrine and metabolic disorders in HTLV-1 infected patients

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