Paraneoplastic motor neuronopathy and malignant acanthosis nigricans

Pinto, Wladimir Bocca Vieira de Rezende; Badia, Bruno de Mattos Lombardi; Souza, Paulo Victor Sgobbi de; Oliveira, Acary Souza Bullé; Silva, Luiz Henrique Libardi; Farias, Igor Braga

doi:10.1590/0004-282x20190076

Cited by 4 publications

(4 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Usually, AN becomes the only clue for a hidden malignancy, and the oral region is usually involved [ 181 , 182 ]. Although the dermatological lesion itself does not display a malignant profile, it behaves similar to a paraneoplastic syndrome [ 183 , 184 , 185 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Acanthosis Nigricans: Pointer of Endocrine Entities

et al. 2022

View full text Add to dashboard Cite

Acanthosis nigricans (AN) has been reported in relation to insulin resistance (IR). We aim to review AN through an endocrine and metabolic perspective focusing on IR in association with metabolic complications such as obesity, diabetes mellitus (DM), and metabolic syndrome (MS) with/without polycystic ovary syndrome (PCOS). We revised English papers on PubMed covering publications from the last 5 years. The current prevalence of AN varies from 4.5 to 74% (or even 100%, depending on the studied population), with equal distribution among females and males. Despite higher incidence with an age-dependent pattern, an alarming escalation of cases has been noted for obesity and MS in younger populations . Most frequent IR-associated sites are the neck, axilla, and knuckles, but unusual locations such as the face have also been reported. Quantitative scales such as Burke have been used to describe the severity of the dermatosis, particularly in correlation with IR elements. Dermoscopic examination are required, for instance, in cases with sulcus cutis, hyperpigmented spots, crista cutis, and papillary projections. A skin biopsy may be necessary, but it is not the rule. Both IR that clinically manifests with or without obesity/MS correlates with AN; most studies are cross-sectional, with only a few longitudinal. The approach varied from screening during school periodic checkups/protocols/programs to subgroups of individuals who were already known to be at high cardio-metabolic risk. AN was associated with type2DM, as well as type 1DM. Females with PCOS may already display metabolic complications in 60–80% of cases, with AN belonging to the associated skin spectrum. AN management depends on underlying conditions, and specific dermatological therapy is not generally required, unless the patient achieves metabolic control, has severe skin lesions, or desires cosmetic improvement. In IR cases, lifestyle interventions can help, including weight control up to bariatric surgery. In addition, metformin is a key player in the field of oral medication against DM type 2, a drug whose indication is extended to PCOS and even to AN itself, outside the specific panel of glucose anomalies. In terms of cosmetic intervention, limited data have been published on melatonin, urea cream, topical retinoids, vitamin D analogs, or alexandrite laser. In conclusion, awareness of IR and its associated clinical features is essential to provide prompt recognition of underlying conditions. AN represents a useful non-invasive surrogate marker of this spectrum in both children and adults. The pivotal role of this dermatosis could massively improve endocrine and metabolic assessments.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Wollina U. et al introduced the idea that AN is like a “two-sided coin”, being either related to IR-MS or malignancies [ 183 , 184 , 185 , 186 ]. A patient with AN may experience this skin lesion while appearing asymptomatic or already under surveillance for IR-related components.…”

Section: Discussionmentioning

confidence: 99%

Acanthosis Nigricans: Pointer of Endocrine Entities

et al. 2022

View full text Add to dashboard Cite

show abstract

“…To our knowledge, only seven cases of AN have been reported in the English literature as summarized in Table 1. [5][6][7][8][9][10][11] However, there have been no such cases reported within China. Following this diagnosis, the patient was transferred to the Oncology Department for systematic chemotherapy.…”

Section: Dovepressmentioning

confidence: 99%

Malignant Acanthosis Nigricans with Recurrent Bladder Cancer: A Case Report and Review of Literature

Zhang¹,

Jiang²,

Lei³

et al. 2021

OTT

View full text Add to dashboard Cite

Acanthosis nigricans (AN) is a rare cutaneous condition that may be a manifestation of certain endocrinological or autoimmune diseases, as well as a potential marker for underlying undiagnosed cancer. AN is classified as either benign or malignant based on its clinical associations. Malignant acanthosis nigricans (MAN), which tends to be extensive and develops rapidly, is considered to be a paraneoplastic syndrome associated with advanced cancer, commonly accompanied by intra-abdominal malignancies. Bladder cancer with AN concomitant with tripe palms (TP) and/or mucosal involvement is relatively rare and, to our knowledge, only seven cases of AN with bladder cancer have been reported in the English literature. However, to date, there have been no reports of bladder cancer with AN concomitant with TP, skin and mucosal involvement. Here, we present a case of a 71year-old male diagnosed with AN coexisting with recurrent bladder cancer and simultaneous TP and oral AN. In addition, we provide a brief review of the available literature on this topic. Early recognition of skin features associated with internal malignancies provides an opportunity for early diagnosis, treatment of the internal malignancy and monitoring of tumor recurrence.

show abstract

“…2,18 An additional case of all 3 paraneoplastic conditions was reported in the setting of metastatic cervical cancer (HPV positive). 19 Per a recent case report and literature review, 20 there have only been 8 cases of acanthosis nigricans reported in bladder transitional cell carcinoma, [20][21][22][23][24][25][26][27] half of which have included oral malignant acanthosis nigricans. [20][21][22][23] Only one report of concurrent cutaneous and oral malignant acanthosis nigricans and triple palms in the setting of bladder cancer has been reported.…”

mentioning

confidence: 99%