Paraneoplastic opsoclonus-myoclonus syndrome in metastatic ovarian carcinoma.

Scholz, Jaqueline; Vieregge, P.; Ruff, Cullen

doi:10.1136/jnnp.57.6.763-a

Cited by 20 publications

(8 citation statements)

References 6 publications

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“…The underlying malignancy is usually a neural crest tumor, mainly neuroblastoma, in children and particularly small-cell lung cancer and oat-cell type tumors with other locations, and breast cancer in adults. It has also been described in association to gynecological carcinoma, bladder tumor, Hodgkin's disease, metastatic ovarian carcinoma, and neurofibrosarcoma [3,5,13,15,21,54,62,63]. Frequently associated symptoms include ataxia, tremor, gait and stance dysfunction, altered mental status, head and face dyskinesias, and progressive encephalomyelitis with rigidity [13].…”

Section: Opsoclonus-myoclonusmentioning

confidence: 99%

Movement disorders of autoimmune origin

Valldeoriola¹

1999

Journal of Neurology

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In recent years there has been renewed interest in the role of autoimmunity in many neurological disorders such as multiple sclerosis and neurodegenerative diseases. Research advances in this field have led to the discovery of new potential therapeutic strategies. There are, however, only a few neurological disorders in which an autoimmune origin has been adequately documented and definitely confirmed. The most important neurological diseases causing movement disorders in which an autoimmune basis has been demonstrated are summarized in this review. The possible role of immunity with the most frequent movement disorders such as parkinsonism or dystonia is also commented.

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Section: Opsoclonus-myoclonusmentioning

confidence: 99%

Movement disorders of autoimmune origin

Valldeoriola¹

1999

Journal of Neurology

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“…Rarer oncologic associations include melanoma,21 - 23 and other neoplasms of the gynecologic tract,10 , 24 - 27 as well as cancers of the urologic,15 , 28 , 29 hematologic,30 - 32 and gastrointestinal systems 15. Infections (mainly virus), idiopathic cases, and rarely toxic or metabolic disturbances account for the other half.…”

Section: Discussionmentioning

confidence: 99%

Adult-onset opsoclonus-myoclonus-ataxia syndrome as a manifestation of brazilian lyme disease-like syndrome: a case report and review of literature

Lino¹,

Spera²,

Campos³

et al. 2014

ACR

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Described in 1962, the opsoclonus-myoclonus-ataxia syndrome (OMAS) is a rare, neurologically debilitating disorder with distinct characteristics that may begin in childhood or adult life. Although many cases remain without etiological diagnosis, others are related to neoplasms and infectious diseases. We report a 41-year-old previously healthy male with an 8-day history of headache, vertigo, nausea, vomiting, and nystagmus. After a normal brain computed tomography and lymphocytic pleocytosis in cerebral spinal fluid (CSF), intravenous acyclovir therapy was initiated in the emergency room. On the third day of hospitalization, the diagnosis of OMAS was made based on the presence of chaotic and irregular eye movements, dysarthric speech, gait instability, generalized tremor, and myoclonic jerks. In the face of his neurological worsening, ampicillin followed by nonspecific immunotherapy (methylprednisolone and intravenous immunoglobulin) was prescribed, with mild clinical improvement. After a thorough laboratory workup, the definite diagnosis of neuroborreliosis was established and ceftriaxone (4 g/daily/3 wks) and doxycycline (200 mg/day/2 mo) was administered. Toward the end of the ceftriaxone regimen, the neurologic signs substantially improved. We believe this to be the first case description of OMAS as clinical presentation of Brazilian Lyme disease-like syndrome (Baggio-Yoshinari syndrome).

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“…El carcinoma de ovario ha sido relacionado con varios síndromes neurológicos paraneoplásicos: degeneración cerebelosa, polineuropatía sensitivo-motora y polimiositis, pero la asociación con SOM es excepcional (5,6). En nuestro caso, aunque no podemos descartar absolutamente que el cuadro fuese debido a la metástasis parietal, es difícil de asumir esta posibilidad, dada la localización de la lesión respetando tálamo y protuberancia y su reducción considerable con el tratamiento en el momento de iniciarse la sintomatología neurológica.…”

Section: Discussionunclassified

“…Se ha sugerido que estos anticuerpos podrían ser directamente responsables de la patogenia del SOM por reacción cruzada entre epitopos tumorales y antígenos neuronales (12,13). Sin embargo, la relación entre anticuerpos antineuronales y cáncer subyacente no es directa ya que estos anticuerpos anti-Ri han sido descritos en pacientes con SOM sin cáncer (8) y a la inversa se han detectado casos de SOM asociado a cáncer sin anticuerpos circulantes (5). La causa de esta disparidad no se conoce e investigaciones futuras determinarán si la diferente respuesta inmunológica del huésped contra el cáncer y la diferente naturaleza histológica del tumor subyacente podrán explicar estas diferencias.…”

Section: Tabla Iunclassified