Paraneoplastic pemphigus: oral involvement as the sole manifestation.

Bialy-Golan, Anat; Brenner, Sarah; Gj, Anhalt

doi:10.2340/0001555576253254

Cited by 46 publications

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“…Stevens–Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, and medication reactions are just a few examples of conditions with similar clinical characteristics. In addition, there is considerable evidence that most instances are still not diagnosed correctly 4 , 6 , 12 , 13 .…”

Section: Discussionmentioning

confidence: 99%

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Paraneoplastic pemphigus in a patient with T-cell lymphoma, a case report

Molla,

Answar,

Worku

et al. 2024

Annals of Medicine &Amp; Surgery

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Introduction and importance: Paraneoplastic pemphigus is an uncommon autoimmune mucocutaneous disease characterized by severe stomatitis, polymorphous skin eruptions, and the presence of underlying neoplasms. Unique histopathological features include suprabasal acantholysis and clefts with scattered necrotic keratinocytes. Case presentation: A 27-year-old female patient presented with a three-month history of a painless swelling, approximately the size of a pea, on the left lateral aspect of her neck and axillary area. This swelling progressively increased in size and number. Additionally, she had reddish, itchy, raised skin lesions over her elbows bilaterally, which gradually spread to involve most of her body, including her lips, tongue, and buccal mucosa. These skin lesions were associated with difficulty swallowing both liquid and solid foods. A diagnostic test, including a biopsy, confirmed the diagnosis of paraneoplastic pemphigus. Subsequently, the patient was managed with chemotherapy and other supportive measures, leading to improvement and eventual discharge. Clinical discussion: Paraneoplastic pemphigus is a rare blistering disorder associated with neoplasms, often presenting diagnostic and treatment challenges. Patients with PNP may develop a diverse range of lesions. It is crucial to promptly recognize and manage the underlying malignancy for improved patient outcomes. Conclusion: This case highlights the rare association between T-cell lymphoma and paraneoplastic pemphigus. Clinicians should also remain vigilant for the possibility of paraneoplastic pemphigus in lymphomas that are not of B-cell lineage.

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Section: Discussionmentioning

confidence: 99%

“…Similar conditions like Stevens–Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, and medication reactions can make diagnosis difficult. Furthermore, many cases of PNP are still not correctly diagnosed 4 – 6 . Diagnosis is typically made using clinical, histological, and immunofluorescent tests 7 .…”

Section: Introductionmentioning

confidence: 99%

Paraneoplastic pemphigus in a patient with T-cell lymphoma, a case report

Molla,

Answar,

Worku

et al. 2024

Annals of Medicine &Amp; Surgery

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Periodontal Medicine Including Biopsy Techniques

Noonan¹,

Kabani²,

Dibart

2007

Practical Advanced Periodontal Surgery

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Dermatoses of the Oral Cavity and Lips

Scully¹

2016

Rook's Textbook of Dermatology, Ninth Edition

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Oral and labial lesions are usually the result of local disease but may be the early signs of systemic disease, including dermatological disorders, and in some instances may cause the main symptoms. This chapter mainly discusses disorders of the periodontal and mucosal tissues that may be related to skin disease and that may present at a dermatology clinic. It should be borne in mind that the professionals most competent in diagnosing and treating oral diseases are those with formal dental training and who are therefore in a position to understand the full complexities of the region. This chapter is divided into a brief discussion of the biology of the mouth, an overview of the more common signs and symptoms affecting specific oral tissues, discussion of the disorders of the oral mucosa of most relevance to dermatology and a tabulated review of oral manifestations of systemic diseases. Only the more classic oral lesions are illustrated. For reasons of space restrictions, diseases affecting the teeth, salivary glands, jaws or temporomandibular joints are not discussed in any depth.

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Paraneoplastic pemphigus: oral involvement as the sole manifestation.

Abstract: No abstract available

Cited by 46 publications

References 0 publications

Paraneoplastic pemphigus in a patient with T-cell lymphoma, a case report

Paraneoplastic pemphigus in a patient with T-cell lymphoma, a case report

Periodontal Medicine Including Biopsy Techniques

Dermatoses of the Oral Cavity and Lips

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