Paraneoplastic Raynaud’s Phenomenon as an Initial Manifestation of Lung Cancer?

Lokineni, Sravani; Nepal, Mahesh Raj; Mohamed, Abdelrahman

doi:10.12890/2021_002690

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…Beau lines can also be reflective of vascular flow compromise to the tips of digits such as in Raynaud phenomena. Systemic responses to underlying neoplasms manifesting as paraneoplastic phenomena are well-reported, and Raynaud phenomena can result from underlying hematologic or solid organ malignancy [ 7 , 8 ].…”

Section: Discussionmentioning

confidence: 99%

Dystrophic Nails: An Unusual Clue to Recurrent Lymphoma

Cherabuddi¹,

Donthireddy²

2022

Cureus

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Nail changes are a well-known phenomenon in T-cell lymphoma but have not been reported as widely in Bcell lymphomas and Hodgkin lymphomas. We describe a patient with a history of diffuse large B-cell lymphoma in a background of nodular lymphocyte predominant Hodgkin lymphoma treated eight years prior who developed new nail changes that were noted on a routine surveillance visit. He had developed symptoms of painful fingertips that became white and required him to wear gloves even in warm weather, suggestive of Raynaud phenomenon. Due to a suspicion of a paraneoplastic phenomenon, a positron emission tomography-computed tomography was obtained, which showed fluorodeoxyglucose avid uptake involving the spleen and retroperitoneal, para-aortic, and right inguinal lymph nodes. Right inguinal lymph node biopsy was non-diagnostic and a splenectomy was performed. Pathology evaluation of the spleen revealed recurrent nodular lymphocyte-predominant Hodgkin lymphoma. Treatment was initiated with rituximab-based systemic therapy. The Beau lines grew out eventually with normal new nail growth and there was an improvement in Raynaud phenomenon after systemic treatment.

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Section: Discussionmentioning

confidence: 99%

Dystrophic Nails: An Unusual Clue to Recurrent Lymphoma

Cherabuddi¹,

Donthireddy²

2022

Cureus

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Other Secondary Causes

Hughes,

Shah

2024

Raynaud’s Phenomenon

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Association between systemic sclerosis, palmar fasciitis with polyarthritis, Raynaud’s phenomenon and erythromelalgia with underlying malignancy

Nowak¹,

Wright²

2022

Reumatologia

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The symptoms of a rheumatic disease may also be a sign of a proliferative process. These include conditions that present with skin and vascular changes such as systemic sclerosis and Raynaud's phenomenon with peripheral ischaemia and ulceration. Furthermore, the less common conditions -erythromelalgia or palmar fasciitis with polyarthritis may also accompany cancer. In this article, we discuss the association of diffuse systemic sclerosis with anorectal tumor, palmar fasciitis and polyarthritis with ovarian cancer, erythromelalgia with underlying ovarian malignancy and Raynaud's phenomenon and digital ischemia associated with renal carcinoma. Based on the literature review on this topic we highlighted the importance of recognizing paraneoplastic syndromes at an early stage. This is a crucial point in the adequate management of a patient. Many of the paraneoplastic symptoms of rheumatic and other described conditions may regress with the management of the underlying malignancy..

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Paraneoplastic Raynaud’s Phenomenon as an Initial Manifestation of Lung Cancer?

Cited by 3 publications

References 7 publications

Dystrophic Nails: An Unusual Clue to Recurrent Lymphoma

Dystrophic Nails: An Unusual Clue to Recurrent Lymphoma

Other Secondary Causes

Association between systemic sclerosis, palmar fasciitis with polyarthritis, Raynaud’s phenomenon and erythromelalgia with underlying malignancy

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