Paraneoplastic syndrome-associated neuronal antibodies in adult ADHD

Haukanes, Bjørn Ivar; Hegvik, Tor‐Arne; Eichler, Tilo Wolf; Haavik, Jan; Vedeler, Christian A.

doi:10.1016/j.jneuroim.2015.08.018

Cited by 3 publications

(12 citation statements)

References 27 publications

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“…; 4024Amph, Ma1, Ma2, CRMP-5/CV2, Tr, Hu, Rec, Ri, YoIIFDSM-IV100%/100%-Moon et al 2014 [47]South Korea– 12-14S (r)Non-stiff amphiphysin syndrome20/207/2058*; 4012Amph., Hu, Yo, Ri, Ma2, CRMP-5.Im.bl.None25%/25%Irritability, psychosisLaadhar et al 2015 [17]Tunisia -?S (c)Psychiatric patHealthy controls5/1030/410/1030/4143*; 2841*; 22ANNA, PCA1, ANAHu, Ri, YoWB, IIFDSM-IV100%/100%Schizophrenia, schizoaff. And bipolar disord.Haukanes et al 2015 [43]Norway -?S (c)ADHD patHealthy controls0/1690/560/1690/5633*; 5035*; 55Yo, Amph, CRMP-5, Ma2, Ri, HuYo, Amph, CRMP-5/CV2, Ma2, Ri, HuIm.bl, WB, IIFDSM-IV100%/−-Kruse et al 2015 [44]US (Roch)- 02–11S (r)Psychiatric inpatHealthy controls1/2130/173?? ;??Hu, Ri, SOX1, Yo, CRMP-5/CV2, Amph, TrIm.bl, IIF, ELISAChart review100%/100%Pers ch, paranoia, agitation etcEndres et al 2015 [42]Germany – 06-13S (c)Pat with psychotic synd.…”

Section: Resultsmentioning

confidence: 99%

“…We identified 27 original publications that met eligibility criteria [2, 17, 25–49]. Data about the serum prevalence of well-characterized onconeural antibodies in patients with psychiatric disorders were available from 6 papers [17, 29, 41, 43, 44, 46]. Authors of 1 paper reported on the prevalence of anti-Purkinje cell antibodies “similar to those found in paraneoplastic cerebellar degeneration”, but did not specify if tests for well-characterized onconeural antibodies were performed [39].…”

Section: Resultsmentioning

confidence: 99%

“…The majority of studies employed immunoblot or western blot techniques as the reference standard for detecting onconeuronal antibodies [2, 17, 26–28, 30–37, 40, 42–47], often in combination with indirect immunoflourocence (IIF) or immunhistochemistry [2, 17, 26–28, 30–34, 37, 40, 43, 44, 46, 48, 49]. When immunoblot/western blot was not used, IIF was performed [25, 29, 38, 39, 41].…”

Section: Resultsmentioning

confidence: 99%

“…Six studies used a validated reference standard for judgment of psychiatric disorders (ICD-10, DSM-III-R or DSM-IV) [17, 29, 39, 41, 43, 46]. Three other studies also included patients with psychiatric disorders [42, 44, 45].…”

Section: Resultsmentioning

confidence: 99%

“…Six studies reported on the prevalence of 3 or more well-characterized onconeural antibodies in patients with psychiatric disorders [17, 29, 41, 43, 44, 46]. Dahm et al screened patients with schizophrenia ( n = 1378), affective disorders ( n = 310), borderline personality disorders ( n = 42) and healthy blood donors ( n = 1703) for the presence of a wide range of onconeural antibodies (all as listed in this review protocol, except anti-SOX1).…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

What is the significance of onconeural antibodies for psychiatric symptomatology? A systematic review

Sæther¹,

Schou²,

Kondziella³

2017

BMC Psychiatry

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BackgroundPatients with intracellular onconeural antibodies may present with neuro-psychiatric syndromes. We aimed to evaluate the evidence for an association between well-characterized onconeural antibodies and psychiatric symptoms in patients with and without paraneoplastic central nervous system syndromes.MethodsEligible studies were selected from 1980 until February 2017 according to standardized review criteria and evaluated using Quality Assessment of Diagnostic Accuracy Studies−2 (QUADAS-2). We included studies describing the psychiatric symptomatology of onconeural antibody positive patients and the prevalence of onconeural antibodies in patients with psychiatric disorders.ResultsTwenty-seven studies met the inclusion criteria. Six studies reported on the prevalence of well-characterized onconeural antibodies in patients with different psychiatric disorders, ranging from 0% to 4.9%. Antibody prevalence in controls was available from three studies, ranging from 0% to 2.8%. Data heterogeneity precluded a meta-analysis. Two cerebrospinal fluid studies found well-characterized onconeural antibodies in 3.5% and 0% of patients with psychotic and depressive syndromes, respectively.ConclusionsThe available evidence suggests that the prevalence of well-characterized onconeural antibodies in patients with psychiatric disorders is generally low. However, the question whether onconeural antibodies are important in select patients with a purely psychiatric phenotype needs to be addressed by appropriately designed studies in the future.Electronic supplementary materialThe online version of this article (doi:10.1186/s12888-017-1325-z) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

What is the significance of onconeural antibodies for psychiatric symptomatology? A systematic review

Sæther¹,

Schou²,

Kondziella³

2017

BMC Psychiatry

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Autoantibody-associated psychiatric symptoms and syndromes in adults: A narrative review and proposed diagnostic approach

Hansen

Lipp

Vogelgsang

et al. 2020

Brain, Behavior, & Immunity - Health

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Background Autoimmune-mediated encephalitis is a disease that often encompasses psychiatric symptoms as its first clinical manifestation’s predominant and isolated characteristic. Novel guidelines even distinguish autoimmune psychosis from autoimmune encephalitis. The aim of this review is thus to explore whether a wide range of psychiatric symptoms and syndromes are associated or correlate with autoantibodies. Methods We conducted a PubMed search to identify appropriate articles concerning serum and/or cerebrospinal fluid (CSF) autoantibodies associated with psychiatric symptoms and syndromes between 2000 and 2020. Relying on this data, we developed a diagnostic approach to optimize the detection of autoantibodies in psychiatric patients, potentially leading to the approval of an immunotherapy. Results We detected 10 major psychiatric symptoms and syndromes often reported to be associated with serum and/or CSF autoantibodies comprising altered consciousness, disorientation, memory impairment, obsessive-compulsive behavior, psychosis, catatonia, mood dysfunction, anxiety, behavioral abnormalities (autism, hyperkinetic), and sleeping dysfunction. The following psychiatric diagnoses were associated with serum and/or CSF autoantibodies: psychosis and schizophrenia spectrum disorders, mood disorders, minor and major neurocognitive impairment, obsessive-compulsive disorder, autism spectrum disorders (ASD), attention deficit hyperactivity disorder (ADHD), anxiety disorders, eating disorders and addiction. By relying on these symptom clusters and diagnoses in terms of onset and their duration, we classified a subacute or subchronic psychiatric syndrome in patients that should be screened for autoantibodies. We propose further diagnostics entailing CSF analysis, electroencephalography and magnetic resonance imaging of the brain. Exploiting these technologies enables standardized and accurate diagnosis of autoantibody-associated psychiatric symptoms and syndromes to deliver early immunotherapy. Conclusions We have developed a clinical diagnostic pathway for classifying subgroups of psychiatric patients whose psychiatric symptoms indicate a suspected autoimmune origin.

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The clinical significance of atypical indirect immunofluorescence patterns on primate cerebellum in paraneoplastic antibody screening

Godelaine

Bossuyt

Poesen

2019

Autoimmun Highlights

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Screening for paraneoplastic antibodies is often performed by means of indirect immunofluorescence on primate cerebellar slices. However, atypical immunofluorescence patterns, i.e. patterns that are not specifically related to paraneoplastic antibodies, are often reported. The clinical significance of these patterns is not clear. Therefore, the purpose of this study was to determine the significance and diagnostic value-in terms of a paraneoplastic neurological syndrome or other neurological disease being diagnosed in the patient-of such atypical immunofluorescence screening patterns on primate cerebellum. Methods: This study is a retrospective single center study including atypical indirect immunofluorescence screening patterns of patients with a negative or absent typing assay for intraneuronal and anti-amphiphysin paraneoplastic antibodies. Patients with a positive typing assay or without final diagnosis were excluded. Included patients were grouped according to (i) reported immunofluorescence pattern and (ii) established diagnosis, after which contingency table analyses were performed to investigate an interrelation between reported pattern and diagnostic group. Results: In 3.7% of cases, patients with an atypical pattern obtained a final diagnosis of a paraneoplastic neurological syndrome. The presence of atypical patterns was more prominent in patients with epilepsy or peripheral neuropathies (p Monte Carlo simulation = 0.026), without, however, adding any diagnostic information. Conclusions: An atypical indirect immunofluorescence pattern on primate cerebellum in the screening for paraneoplastic antibodies has only very minor relevance with respect to paraneoplastic neurological syndromes or any other neurological disease, recommending clinicians to interpret the results of positive screening assays for such antibodies with care.

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Paraneoplastic syndrome-associated neuronal antibodies in adult ADHD

Cited by 3 publications

References 27 publications

What is the significance of onconeural antibodies for psychiatric symptomatology? A systematic review

What is the significance of onconeural antibodies for psychiatric symptomatology? A systematic review

Autoantibody-associated psychiatric symptoms and syndromes in adults: A narrative review and proposed diagnostic approach

The clinical significance of atypical indirect immunofluorescence patterns on primate cerebellum in paraneoplastic antibody screening

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