Paraneoplastic syndromes of the peripheral nerves

Rudnicki, Stacy A.; Dalmau, Josep

doi:10.1097/01.wco.0000173462.17135.ee

Cited by 95 publications

(43 citation statements)

References 70 publications

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“…Examples include anti-Hu associated with small cell lung cancer (SCLC) and neuroblastoma, anti-Yo with breast and ovarian cancer, anti-Tr with Hodgkin’s lymphoma, anti-Ma with testicular cancer, anti-Ri with breast cancer and neuroblastoma, anti-amphiphysin with breast cancer, Lambert-Eaton myasthenic syndrome antibody with SCLC, recoverin with SCLC and so on [7] (Table 1, [21,22]). However, these antibodies might not be positive in all cases of paraneoplastic neurological syndromes as seen in our patient [23]. …”

Section: Discussionmentioning

confidence: 92%

Hodgkin’s lymphoma presenting as a complex paraneoplastic neurological syndrome: a case report

2013

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IntroductionParaneoplastic neuropathies are rare. They are often difficult to diagnose, especially when they precede the diagnosis of cancer. Hodgkin's lymphoma is associated with multiple paraneoplastic neurological syndromes, of which demyelinating polyneuropathies are very unusual. Association with chronic inflammatory demyelinating polyneuropathy is even more uncommon.Case presentationWe report the rare case of a 74-year-old Caucasian man who presented with a complex neurological syndrome and was eventually diagnosed with the nodular sclerosing variant of Hodgkin's lymphoma. With timely diagnosis and early institution of treatment of the underlying malignancy, our patient began to show gradual improvement of his symptoms.ConclusionHodgkin's lymphoma is associated with several paraneoplastic neurological syndromes. Sometimes it can be the only presenting feature of an underlying Hodgkin's lymphoma, posing a diagnostic challenge. Prompt oncologic treatment and immunotherapy can be beneficial if instituted early in the course of the disease.

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Section: Discussionmentioning

confidence: 92%

Hodgkin’s lymphoma presenting as a complex paraneoplastic neurological syndrome: a case report

2013

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“…Neuronal antigens expressed by the tumor stimulate an immune response characterized by T cells, antibodies, or both, which attack not only the tumor but also the neural tissue [8]. Although these scenarios could be expected in lymphomas, nervous system involvement is not commonly reported in reviews of SS [1,2].…”

Section: Discussionmentioning

confidence: 99%

Peripheral Neuropathy in Sézary Syndrome: Coincidence or a Part of the Syndrome?

Karadağ¹,

Gulunay²,

Öztekin³

et al. 2013

tjh

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“…Contrastingly, Hodgkin’s lymphoma (HL) usually damages peripheral nerves by an inflammatory process and may be associated with Guillain–Barre syndrome or chronic inflammatory demyelinating polyneuropathy 5. Paraneoplastic neuropathies have a heterogeneous phenotype and the classical sensory ganglionopathy may be absent 6. HL has been reported in association with a sensory neuropathy and various paraneoplastic antibodies, akin to anti-Hu.…”

Section: Discussionmentioning

confidence: 99%