Paraneoplastik özellik gösteren metabolik hastalıklar

Comparison of diagnostic methods in onychomycosis

“…In the literature, the positivity and sensitivity rates of the culture analysis are generally found to be lower compared to the histopathological examination with PAS staining and direct microscopic examination with KOH. The culture positivity rate as reported to be low (19%) by Ceren et al (22), higher (52%) by Gianni et al (30) and vary between 19 and 52% in other studies (17,21,(23)(24)(25)28). However, the absence of growth in culture does not exclude the diagnosis of onychomycosis.…”

“…In the literature, it has been shown that the most sensitive method in the diagnosis of onychomycosis is the histopathological examination with PAS staining. In previous studies, the positivity of this test varied between 47 and 90%, and its sensitivity ranged from 80 to 92% (13,(19)(20)(21)(22)(23)(24)(25)(26)(28)(29)(30)33). The PAS method was reported to have a high sensitivity rate of 80% by Karimzadegan-Nia et al (29), 82% by Wilsmann-Theis et al (26), 90% by Shenoy et al (18), 91.6% by Jeelani et al (19), and 92% by Weinberg et al (20).…”

“…In many studies, the positivity rate of this diagnostic method was found to be lower compared to the histopathological examination with PAS staining and higher compared to the culture analysis (17,18,(23)(24)(25); however, there are also researchers reporting that the direct microscopic examination with KOH had the lowest positivity rate (19,20). In contrast, in two studies conducted in Turkey, Aydıngöz et al (21) and Ceren et al (22) determined the KOH method to have the highest positivity at 96% and 85%, respectively. In onychomycosis, the sensitivity of this test varies in a wide range from 44 to 92% (17)(18)(19)(20)22,(26)(27)(28)(29).…”

“…Furthermore, secondary contamination and air bubbles mimicking fungal structures can produce false positive results. In the literature, the positivity rates of the direct microscopic examination with KOH in onychomycosis vary between 32 and 96% (17)(18)(19)(20)(21)(22). In many studies, the positivity rate of this diagnostic method was found to be lower compared to the histopathological examination with PAS staining and higher compared to the culture analysis (17,18,(23)(24)(25); however, there are also researchers reporting that the direct microscopic examination with KOH had the lowest positivity rate (19,20).…”

“…Consistent with the literature, in the current study, the positivity and sensitivity rates of the culture analysis were 38.5% and 49.2%, respectively, but it had the lowest sensitivity among the three diagnostic methods. Although this analysis allows for the fungal agent to be classified as a dermatophyte, non-dermatophyte mold, or yeast, it does not provide information on whether the growing agent is a true pathogen or there is any contamination (21,31). Grover et al (23) detected fungi in 44% of 120 cases, and 70.2% of these positive cases were identified to have Trichophyton spp.…”