Paranoid schizophrenia versus schizoaffective disorder: Neuropsychological aspects

Leposavić, Ljubica; Leposavić, Ivana; Šaula-Marojević, Biljana; Gavrilovic, Predrag

doi:10.2298/sarh1508391l

Cited by 5 publications

(4 citation statements)

References 25 publications

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“…The subtypes of schizophrenia are generally not studied separately and studies involving patients with schizophrenia also include patients with schizoaffective disorder (Brazil, 2014a;Leposavic et al, 2015;Mattila et al, 2015). Although it did not seem predictor of treatment response (Mattila et al, 2015), a diagnosis of schizoaffective disorders, compared to that of paranoid schizophrenia, was likely to associated with SGA switching, as found in our study.…”

Section: Comparison With Previous Studiessupporting

confidence: 51%

Switching Between Second-Generation Antipsychotics in Patients with Schizophrenia and Schizoaffective Disorder: 10-Year Cohort Study in Brazil

2021

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Objective: Switching between second-generation antipsychotics (SGAs) is a common clinical practice in the treatment of schizophrenia and schizoaffective disorders due to differences in the drugs’ tolerability and safety profiles as well as the challenge of obtaining an ideal response. However, the factors associated with SGA switching remain uncertain and related real-world data are scarce. The main objective was to identify the factors associated with the switching of SGAs in patients with schizophrenia or schizoaffective disorder.Methods: We conducted a retrospective cohort study of outpatients with schizophrenia or schizoaffective disorder, who were aged ≥18 years and received a SGA (clozapine, olanzapine, risperidone, quetiapine or ziprasidone) from a Brazilian pharmaceutical assistance program for at least 3 months. We identified SGA users from 2008 to 2017 by using a national administrative database (Ambulatory Information System-SIA/SUS). The factors associated with the switches were evaluated by Cox proportional hazards regression and adjusted for sex and age; the confidence interval was set at 95% (95% CI).Results: In total, 563,765 patients were included. Female sex, advanced age of ≥70 years, residence in the Brazilian northeast region, and the type of antipsychotic used were associated with an increased risk of switching (p < 0.001). The incidence of switching ranged from 37.6/100 person-years for clozapine users to 58.2/100 person-years for risperidone users. Compared to the adjusted hazard ratio, for clozapine users, the corresponding ratios for risperidone, ziprasidone, quetiapine and olanzapine were 1.59 (95% CI, 1.57–1.61), 1.41 (95% CI, 1.39–1.44), 1.25 (95% CI, 1.23–1.26) and 1.11 (95% CI, 1.10–1.12) respectively.Conclusion: The groups most susceptible to SGA switching in real-life setting were older individuals, women, and those living in the Brazilian northeast region. Risperidone was associated with the highest risk of switching and as expected, clozapine was associated with the lowest risk of switching than that associated with the other SGAs.

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Section: Comparison With Previous Studiessupporting

confidence: 51%

Switching Between Second-Generation Antipsychotics in Patients with Schizophrenia and Schizoaffective Disorder: 10-Year Cohort Study in Brazil

2021

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“…35 Identifying these biomarkers could contribute to the diagnosis and treatment of schizophrenia. 36 associated with neurocognitive deficits, 37 inhibitory control, intellectual disability, 38,39 working memory, 40 visual and verbal memory, speed processing, attention, 32,[41][42][43][44][45] visual construction, 46 social cognition, 46 theory of mind, [47][48][49] sensory processing, facial recognition deficits, 50 and decision making. 49,51 The identification of these markers could contribute to the diagnosis and treatment of schizophrenia 36 Regarding decision-making in patients with schizophrenia, most studies showed deficiencies in the Iowa Gambling Test (IGT), which suggests a preference for disadvantageous cards, 52 which poses a reduced sensitivity to punishments, being unable to regulate their decision-making to implement practical strategies, even when the probabilities of winning or losing are explicitly revealed.…”

Section: Discussionmentioning

confidence: 99%

Executive function and decision-making in Colombian patients with paranoid schizophrenia

Acosta-Lopez,

Cervantes-Henriquez,

Téllez-Bustillo

et al. 2024

F1000Res

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Background Schizophrenia (SCZD) is a mental disorder characterized by cognitive dysfunction, impaired decision-making abilities, abnormalities in brain functioning, and specific genetic markers. Ethnic and racial factors influence the development and presentation of schizophrenia, with different groups experiencing different levels of risk and exhibiting different patterns of mental disorders. Objective We sought to investigate the executive function and decision-making profile of Schizophrenia participants from Barranquilla, Colombia, which have a high genetic mixture and significant ethnic and racial diversity. Methods The sample consists of 40 individuals, 20 diagnosed with paranoid schizophrenia and 20 controls. We use the BANFE neuropsychological battery and the Iowa Gambling task to measure executive function and decision-making processes. Results The study found differences in cognitive performance, measured by the Neuropsychological Battery of Executive Functions and Frontal Lobes, in the medial orbit, anterior prefrontal, dorsolateral, and total executive function measures. In decision-making, as measured by the Iowa Gambling Test, there were also differences between the two groups, with those with schizophrenia performing worse and showing a preference for disadvantageous options. The study also found that there were no significant differences in socio-demographic characteristics between the two groups but that there were differences in terms of socio-economic status and educational level. Conclusion This study found that individuals with paranoid schizophrenia had significant differences in their prefrontal cortex compared to those without the condition, specifically in the dorsolateral and orbital-prefrontal cortex. These differences may be linked to difficulties adjusting to their environment and processing reinforcement, leading to impaired learning and arousal disturbances.

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“…Paranoid schizophrenia is the most frequent subtype of schizophrenia [4]. Although the subtypes of schizophrenia were eliminated from Diagnostic and Statistical Manual of Mental Disorder (DSM), paranoia remains the most common delusion among patients diagnosed with schizophrenia [5,6].…”

Section: Introductionmentioning

confidence: 99%

Paranoid Schizophrenia: Case Report

Šulskutė,

Galnaitytė,

Usonytė

2023

Health Sciences

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Schizophrenia is a complex chronic mental disorder, that manifests with positive and negative symptoms, as well as disorganized behavior and cognitive changes, and affects around 1% of the population. Paranoia remains the most common delusion among patients diagnosed with schizophrenia. Although the etiology of schizophrenia remains unknown and it is thought that genetic and environmental factors contribute to its development, studies suggest that childhood bullying victimization is likely to be a significant risk factor for having paranoid ideas. The clinical case of the young man diagnosed with paranoid schizophrenia is discussed in this article.

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Paranoid schizophrenia versus schizoaffective disorder: Neuropsychological aspects

Abstract: In the remission phase, patients with paranoid schizophrenia expressed cognitive disorders in moderate degree, but when it comes to patients with schizoaffective disorder, more massive cognitive, deficits were registered.

Cited by 5 publications

References 25 publications

Switching Between Second-Generation Antipsychotics in Patients with Schizophrenia and Schizoaffective Disorder: 10-Year Cohort Study in Brazil

Switching Between Second-Generation Antipsychotics in Patients with Schizophrenia and Schizoaffective Disorder: 10-Year Cohort Study in Brazil

Executive function and decision-making in Colombian patients with paranoid schizophrenia

Paranoid Schizophrenia: Case Report

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